Thiazides in the management of hypertension in older adults – a systematic review [PDF]
BMC Geriatrics, 2017 Background Thiazides are commonly prescribed to older people for the management of hypertension. The objective of this study was to identify the evidence on the risks and benefits of their use among adults aged ≥65 years and to develop recommendations to
Christina Sommerauer +9 more
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The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states. [PDF]
PLoS ONE, 2017 Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC).
Saeed Alshahrani +9 more
doaj +2 more sources
Comparative safety and effectiveness of angiotensin converting enzyme inhibitors and thiazides and thiazide‐like diuretics under strict monotherapy [PDF]
The Journal of Clinical HypertensionPrevious work comparing safety and effectiveness outcomes for new initiators of angiotensin converting‐enzyme inhibitors (ACEi) and thiazides demonstrated more favorable outcomes for thiazides, although cohort definitions allowed for addition of a second
Tara V. Anand +4 more
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Rational prescribing in primary care (RaPP): economic evaluation of an intervention to improve professional practice. [PDF]
PLoS Medicine, 2006 BACKGROUND: Interventions designed to narrow the gap between research findings and clinical practice may be effective, but also costly. Economic evaluations are necessary to judge whether such interventions are worth the effort.
Atle Fretheim +2 more
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Drug Design, Development and Therapy, 2018 Lei Cheng,1 Keyan Zhang,1 Zhenyong Zhang2 1Department of Thyroid Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China; 2The Second Department of Clinical Oncology, Shengjing Hospital of China Medical University ...
Cheng L, Zhang K, Zhang Z
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Antihypertensive Medications and Risk of Melanoma and Keratinocyte Carcinomas: A Systematic Review and Meta-Analysis [PDF]
JID InnovationsSome antihypertensive medications are photosensitizing. The implications for skin cancer risk remain unclear because results from prior studies are inconsistent and as new evidence is published.
Olivia G. Cohen +8 more
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Thiazides induce glucose intolerance through inhibition of mitochondrial carbonic anhydrase 5b in β-cells [PDF]
, 2022 Thiazides are associated with glucose intolerance and new onset diabetes mellitus, but the molecular mechanisms remain elusive. The aim of this study was to decipher the molecular basis of thiazide-induced glucose intolerance.
Albano, Giuseppe +5 more
core +1 more source
Renal Failure, 2023 Background and objective Thiazide diuretics are first-line drugs for the treatment of hypertension, but hypertension treatment guidelines have systematically discouraged their use in patients with advanced chronic kidney disease (CKD). For the first time,
Flávio Teles +7 more
doaj +1 more source
Difficulties in treatment with thiazide diuretics in the elderly
Arterial Hypertension, 2023 Thiazides are in common use also in people over 65 years of age. Their side effects before the age of 60 are not very common and usually refer to the development of hypokalemia.
Jerzy Głuszek, Teresa Kosicka
doaj +1 more source
Journal of Pharmacy and Bioallied Sciences, 2020 Objective: The objective of this study was to determine the association between antihypertensive drug use and new-onset diabetes (NOD) in patients with hypertension (HTN).
Sneha M Sabu +4 more
doaj +1 more source