The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states. [PDF]
PLoS ONE, 2017 Thiazide derivatives including Hydrochlorothiazide (HCTZ) represent the most common treatment of mild to moderate hypertension. Thiazides initially enhance diuresis via inhibition of the kidney Na+-Cl- Cotransporter (NCC).
Saeed Alshahrani +9 more
doaj +1 more source
Association of antihypertensive monotherapy with serum sodium and potassium levels in Chinese patients [PDF]
, 2009 <b>Background</b> International guidelines on management of hypertension recommend any major classes of antihypertensive drugs. However, the low prescribing rate of thiazides has been attributed to concerns about electrolyte disturbances and ...
Bissram +17 more
core +2 more sources
JBMR Plus, 2022 Thiazide diuretics are commonly used antihypertensive agents. Until today, whether their use reduces fracture risk remains unclear. Our objective was to conduct a systematic review of thiazide diuretics’ effects on fractures and bone mineral density (BMD)
Louis‐Charles Desbiens +6 more
doaj +1 more source
Hydrochlorothiazide reduces urinary calcium excretion in a child with Lowe syndrome. [PDF]
, 2015 There is a growing recognition that children with Lowe syndrome are at risk of nephrocalcinosis and nephrolithiasis from hypercalciuria. Increased fluid intake and correction of metabolic acidosis have remained the focus for intervention but are not ...
Butani, Lavjay
core +1 more source
Thiazides in advanced chronic kidney disease—time for a randomized controlled trial? [PDF]
, 2015 Purpose of review: Chronic kidney disease is common, associated with increased cardiovascular risk, and frequently complicated by hypertension, requiring multiple agents for control.
Agarwal, Rajiv, Sinha, Arjun D.
core +1 more source
Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cells [PDF]
, 2017 Thiazides block Na+ reabsorption while enhancing Ca2 + reabsorption in the kidney. As previously demonstrated in immortalized mouse DCT (MDCT) cells, chlorothiazide application induced a robust plasma membrane hyperpolarization, which increased Ca2 ...
Shrier, Alvin +2 more
core +1 more source
Thiazides in the management of hypertension in older adults – a systematic review
BMC Geriatrics, 2017 Background Thiazides are commonly prescribed to older people for the management of hypertension. The objective of this study was to identify the evidence on the risks and benefits of their use among adults aged ≥65 years and to develop recommendations to
Christina Sommerauer +9 more
doaj +1 more source
A theory-based process evaluation alongside a randomised controlled trial of printed educational messages to increase primary care physicians' prescription of thiazide diuretics for hypertension [ISRCTN72772651] [PDF]
, 2016 Background Pragmatic trials of implementation interventions focus on evaluating whether an intervention changes professional behaviour under real-world conditions rather than investigating the mechanism through which change occurs.
A Fretheim +53 more
core +3 more sources
A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? [PDF]
, 2014 Aims: Hyponatraemia is one of the major adverse effects of thiazide and thiazide-like diuretics and the leading cause of drug-induced hyponatraemia requiring hospital admission.
Barber, Jennifer +9 more
core +4 more sources
Back to thiazide-diuretics for hypertension: reflections after a decade of irrational prescribing
BMC Family Practice, 2003 Background Whether newer antihypertensive drugs, such as calcium channel blockers, angiotensin converting enzyme inhibitors and α blockers are more effective than thiazides and β blockers in preventing coronary disease, has been debated for years ...
Fretheim Atle
doaj +1 more source