Results 31 to 40 of about 35,784 (226)

Activating Triplet Excitons in COFs via Layer‐Bridging Co Single Atoms for Photocatalytic H2O2 Production and Tandem C─N Coupling

Angewandte Chemie, EarlyView.
This work demonstrates a layer‐bridging coordination strategy of Co single atoms in COFs that promotes the formation and utilization of triplet excited states. The introduction of Co single atoms induces pronounced energy‐level splitting and enhanced spin–orbit coupling, facilitating the generation of 1O2 and O2•– for efficient photocatalytic H2O2 ...
Guoen Tang, Jianjun Zhang, Guijie Liang, Jinfeng Zhang, Chuanbiao Bie, Jiaguo Yu, Hermenegildo García   +6 more
wiley   +2 more sources

Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications

Angewandte Chemie, EarlyView.
Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika, Matthew Murray, Guillermo Palop, Lee‐Ann J. Keane, Patrick McArdle, Nicholas D. J. Yates, Christopher D. Spicer, Alison Parkin, Martin A. Fascione, Eddie L. Myers   +9 more
wiley   +2 more sources

Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAF^V600E

Molecules, 2023
Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore,
Alaa A. Hassan, Nasr K. Mohamed, Ashraf A. Aly, Mohamed Ramadan, Hesham A. M. Gomaa, Ahmed T. Abdel-Aziz, Bahaa G. M. Youssif, Stefan Bräse, Olaf Fuhr   +8 more
doaj   +1 more source

2-(Benzothiazol-2-ylsulfanyl)acetic acid

Acta Crystallographica Section E, 2010
In the title compound, C9H7NO2S2, the benzine ring is essentially co-planar with the thiazole ring, making a dihedral angle of 0.36 (7)°. In the crystal structure, molecules are linked by intermolecular O—H...N hydrogen bonds
Zhi-li Fang, Jun Wang
doaj   +1 more source

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

Angewandte Chemie, EarlyView.
SOLiD‐MaP is a ligand‐directed photoproximity labeling strategy developed for RNA binding‐site analysis. Singlet oxygen‐mediated labeling creates a proximity‐dependent chemical footprint of bound small molecules on RNA. Coupling this chemistry with mutational profiling enables identification of the ligand‐binding region at nucleotide resolution ...
Lin L. Rietveld, Wei Wu, Filip M. Zawisza, Danny Incarnato, Zeshi Li   +4 more
wiley   +2 more sources

A Wagner-Meerwein-Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles. [PDF]

Angew Chem Int Ed Engl
The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Figueiredo SAC, Abt K, Viehrig K, Jervis PJ, Martins TP, Lacomba I, Li C, Castagnolo D, Leão PN.   +8 more
europepmc   +3 more sources

One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives

Molecules, 2013
A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions.
Hui Zheng, Yi-Jia Mei, Kui Du, Xian-Ting Cao, Peng-Fei Zhang   +4 more
doaj   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

2-[5-(Benzo[d]thiazol-2-yl)thiophen-2-yl]benzo[d]thiazole

Acta Crystallographica Section E, 2010
The structure of the title compound, C18H10N2S3, consists of a central thiophene ring and two terminal thiazole rings. The two S atoms of the thiazole rings are trans to the thiophene S atom sulfur.
Thomas I. A. Gerber, Eric Hosten, Peter Mayer, Kim Potgieter   +3 more
doaj   +1 more source

Benzo[1,2,3]dithiazole Compounds: A History of Synthesis and Their Renewed Applicability in Materials and Synthetic Chemistry, Originating from the Herz Reaction

Reactions, 2021
The benzo[1,2,3]dithiazole is a unique heteroaromatic functionality whose conjugated profile instils some fascinating electronic properties. This has been historically recognized in the design and manufacture of organic dyes early last century. Although,
Alexander J. Nicholls, Ian R. Baxendale
doaj   +1 more source