Results 31 to 40 of about 36,963 (239)

Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAF^V600E

Molecules, 2023
Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore,
Alaa A. Hassan, Nasr K. Mohamed, Ashraf A. Aly, Mohamed Ramadan, Hesham A. M. Gomaa, Ahmed T. Abdel-Aziz, Bahaa G. M. Youssif, Stefan Bräse, Olaf Fuhr   +8 more
doaj   +1 more source

Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide‐Dependent Methyltransferases Using Unactivated Methyl Donors

Angewandte Chemie, EarlyView.
Mixed MtaABC/MtgABC methyltransferase systems were developed for non‐native thiol and aniline methylation using the unactivated methyl donors methanol and glycine betaine. The platform enabled site‐selective and enantioselective methylation with turnover number up to 6000, representing the first enantioselective non‐native catalysis by cobamide ...
Amardeep Kumar, Osman Ishag Adam, Paras Gupta, Jared C. Lewis   +3 more
wiley   +2 more sources

Aromatic Pummerer‐Promoted Stereospecific Cross‐Coupling of Thiazoles With Boronic Esters

Angewandte Chemie, EarlyView.
A lithiation–borylation–aromatic Pummerer (LiBAP) strategy enables stereospecific, C5‐selective C(sp2)–C(sp3) cross‐coupling of thiazoles with boronic esters. By using exocyclic sulfoxide activation to overcome the low nucleophilicity that frustrates SEAr‐type coupling, the method delivers enantioenriched alkylated thiazoles bearing a versatile C2 ...
Mark John P. Mandigma, Julien Lefranc, Louise Eagling, Jasper L. Tyler, Varinder K. Aggarwal   +4 more
wiley   +2 more sources

Synthesis of the Thiazole–Thiazoline Fragment of Largazole Analogues

, 2016
The thiazole–thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps.
Daniel S. Nielsen (2022916), David P. Fairlie (180958), Frederik Diness (1796416)   +2 more
core   +2 more sources

2-[5-(Benzo[d]thiazol-2-yl)thiophen-2-yl]benzo[d]thiazole

Acta Crystallographica Section E, 2010
The structure of the title compound, C18H10N2S3, consists of a central thiophene ring and two terminal thiazole rings. The two S atoms of the thiazole rings are trans to the thiophene S atom sulfur.
Thomas I. A. Gerber, Eric Hosten, Peter Mayer, Kim Potgieter   +3 more
doaj   +1 more source

Synthesis and cytotoxicity evaluation of thiazole conjugated amino acid derivatives

CTU Journal of Innovation and Sustainable Development
This paper presents the three-step synthesis and cytotoxicity evaluation of the thiazole-conjugated amino acid derivatives. Starting from the commercially available benzophenone and thiourea, the thiazole structure was successfully constructed bearing ...
Nhut Linh Huynh, Truong Giang Nguyen, Thi My Tien Nguyen, Pham Xuan Truc Nguyen, Minh Thi Bui, Trong Hieu Le, Vinh Quang Hong, Minh Kiep Do, Hiroyuki Morita, Thi Buu Hue Bui   +9 more
doaj   +1 more source

Thiazole-Induced Surface Passivation and Recrystallization of CH₃NH₃PbI₃ Films for Perovskite Solar Cells with Ultrahigh Fill Factors

, 2018
The quality of perovskite films is a crucial factor governing the photovoltaic performance of perovskite solar cells. However, perovskite films fabricated by the conventional one-step spin-coating procedure are far from ideal due to uncontrollable ...
Feng Hao (1534615), Xin Li (51274), Hongbin Zhang (258308), Qinzhi Hou, Xin Li, Constantinos C. Stoumpos, Jing Ren, Hong Lin, Mercouri G. Kanatzidis, Hong Lin (46089), Hongcai He (6033590), Jiaqi Li (220961), Hui Chen, Jiaqi Li, Jing Ren (107777), Jinshu Wang, Qinzhi Hou (6033587), Jinshu Wang (560636), Feng Hao, Hui Chen (28597), Mercouri G. Kanatzidis (1350288), Constantinos C. Stoumpos (1364667), Hongbin Zhang, Hongcai He   +23 more
core   +1 more source

Atroposelective Pd(0)‐Catalyzed Direct Intermolecular C─H Arylation of Thiazole N‐Oxides Provides Access to Heterobiaryls

Angewandte Chemie, EarlyView.
An enantioselective Pd(0)‐catalysed arylation at the C4‐position of thiazole N‐oxides directly forges the atropochiral heterobiaryl axis. A tailored point‐ and axially chiral monodentate phosphine ensures high reactivities along with a tight stereocontrol.
Vitalii Smal, Nicolai Cramer
wiley   +2 more sources

Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile

Acta Pharmaceutica, 2017
Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d ...
Mohareb Rafat M., Abdallah Amira E. M., Ahmed Ebtsam A.   +2 more
doaj   +1 more source

Benzo[1,2,3]dithiazole Compounds: A History of Synthesis and Their Renewed Applicability in Materials and Synthetic Chemistry, Originating from the Herz Reaction

Reactions, 2021
The benzo[1,2,3]dithiazole is a unique heteroaromatic functionality whose conjugated profile instils some fascinating electronic properties. This has been historically recognized in the design and manufacture of organic dyes early last century. Although,
Alexander J. Nicholls, Ian R. Baxendale
doaj   +1 more source