Results 31 to 40 of about 49,222 (248)

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells [PDF]

, 2016
Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl ...
Buglioni, Simonetta, Carradori, Simone, DE LUCA, Teresa, De Maria, Ruggero, Del Bufalo, Donatella, Desideri, Marianna, DI MARTILE, Marta, Eramo, Adriana, Gabellini, Chiara, Mai, Antonello, Milella, MICHELE STANISLAW, Rotili, Dante, Secci, Daniela, Sette, Giovanni, Trisciuoglio, Daniela   +14 more
core   +4 more sources

Probing Steady‐State Carrier Properties and Charge Transport in Covalent Organic Framework by Frequency‐Domain Terahertz Spectroscopy

Angewandte Chemie, EarlyView.
This work reports a combined frequency‐domain and time‐domain terahertz (THz) spectroscopic approach to elucidate intrinsic carrier properties and transport mechanisms in framework materials over the extended 0.5–20 THz region. Subtle structural and chemical variations are shown to strongly influence THz charge‐transport behavior across the far ...
Satyapriya Nath, Saiprakash Rout, Mahalaxmi Samal, Snehal Haldankar, Md Habib Ahsan, Anol Mondal, Sudeep Tiwari, Adithyan Puthukkudi, Avani KV, Ashis K. Nandy, Shriganesh S. Prabhu, Himansu S. Biswal, Xinliang Feng, Bishnu P. Biswal   +13 more
wiley   +2 more sources

2-[5-(Benzo[d]thiazol-2-yl)thiophen-2-yl]benzo[d]thiazole

Acta Crystallographica Section E, 2010
The structure of the title compound, C18H10N2S3, consists of a central thiophene ring and two terminal thiazole rings. The two S atoms of the thiazole rings are trans to the thiophene S atom sulfur.
Thomas I. A. Gerber, Eric Hosten, Peter Mayer, Kim Potgieter   +3 more
doaj   +1 more source

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport [PDF]

, 2014
A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule ...
Bennion, Melissa, Dandapani, Sivaraman, Dockendorff, Chris, Faloon, Patrick W., Krieger, Monty, Lam, Garrett, Lewis, Timothy A., Munoz, Benito, Nag, Partha P., Negri, Joseph, Nieland, Thomas J.F., Palmer, Michelle A., Paterson, Conor, Penman, Marsha, Perez, José R., Pu, Jun, Schreiber, Stuart L., Youngsaye, Willmen, Yu, Miao   +18 more
core   +3 more sources

One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives

Molecules, 2013
A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions.
Hui Zheng, Yi-Jia Mei, Kui Du, Xian-Ting Cao, Peng-Fei Zhang   +4 more
doaj   +1 more source

Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity [PDF]

, 2018
A series of novel 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C in 75-91% yield.
De Coen, Laurens, Gemili, Muge, Nural, Yahya, Ulger, Mahmut, Yabalak, Erdal   +4 more
core   +1 more source

Synthesis and cytotoxicity evaluation of thiazole conjugated amino acid derivatives

CTU Journal of Innovation and Sustainable Development
This paper presents the three-step synthesis and cytotoxicity evaluation of the thiazole-conjugated amino acid derivatives. Starting from the commercially available benzophenone and thiourea, the thiazole structure was successfully constructed bearing ...
Nhut Linh Huynh, Truong Giang Nguyen, Thi My Tien Nguyen, Pham Xuan Truc Nguyen, Minh Thi Bui, Trong Hieu Le, Vinh Quang Hong, Minh Kiep Do, Hiroyuki Morita, Thi Buu Hue Bui   +9 more
doaj   +1 more source

Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAF^V600E

Molecules, 2023
Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore,
Alaa A. Hassan, Nasr K. Mohamed, Ashraf A. Aly, Mohamed Ramadan, Hesham A. M. Gomaa, Ahmed T. Abdel-Aziz, Bahaa G. M. Youssif, Stefan Bräse, Olaf Fuhr   +8 more
doaj   +1 more source

Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand. [PDF]

, 2020
The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities
Hartwig, John F, Karmel, Caleb, Kharitonova, Elena V, Rubel, Camille Z   +3 more
core   +1 more source

Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile

Acta Pharmaceutica, 2017
Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3- carbonitrile towards thioglycolic acid resulted in thiazole derivative 1. The latter reacted with different chemical reagents to give thiazole, pyrano[2,3-d]thiazole and thiazolo[ 4,5-d ...
Mohareb Rafat M., Abdallah Amira E. M., Ahmed Ebtsam A.   +2 more
doaj   +1 more source