Results 21 to 30 of about 46,327 (259)

Thiazole Ring—A Biologically Active Scaffold

Molecules, 2021
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal ...
A. Petrou, M. Fesatidou, A. Geronikaki
semanticscholar   +1 more source

Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues

Journal of Saudi Chemical Society, 2023
Several new thiazole derivatives linked pyrazole and/or pyridine rings were synthesized based on the versatile precursor 2-(5-acetyl-4-methyl-3-phenylthiazol-2(3H)-ylidene)acetonitrile (1). The synthesized derivatives were optimized using DFT approach in order to inspect the configurations and energies of the HOMO-LUMO orbitals.
Abrar Bayazeed, Rua B. Alnoman, Kahdr Alatawi, Omar M. Alatawi, Alaa M. Alqahtani, Mariam Mojally, Noof A. Alenazi, Nashwa M. El-Metwaly   +7 more
openaire   +2 more sources

First method for dissolving zinc thiazole and re-evaluation of its antibacterial properties against rice bacterial blight disease

Phytopathology Research, 2019
Rice bacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the most destructive diseases in rice-growing regions worldwide. Zinc thiazole is a novel bactericide and has been applied for BB control for 10 years.
Xian Chen, Lan Zhou, Pedro Laborda, Yancun Zhao, Kaihuai Li, Fengquan Liu   +5 more
doaj   +1 more source

Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate [PDF]

Journal of the American Chemical Society, 2008
Thiamin thiazole biosynthesis in eukaryotes is still not completely understood. In this report, a late intermediate, tightly bound to the active site of the Saccharomyces cerevisiae thiazole synthase, was identified as an adenylated thiazole tautomer. The reactivity of this unusual compound was evaluated.
Abhishek, Chatterjee, Frank C, Schroeder, Christopher T, Jurgenson, Steven E, Ealick, Tadhg P, Begley   +4 more
openaire   +2 more sources

Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives.

Experimental parasitology, 2023
In this work, 13 thiosemicarbazones (1a - m) and 16 thiazoles (2a - p) were obtained, which were properly characterized by spectroscopic and spectrometric techniques.
Natali de França Nibbering Santos, Natanael da Silva Bezerra Junior, J. F. de Oliveira, Denise Duarte, José Cleberson Dos Santos Soares, Diego Santa Clara Marques, A. C. Da Silva Santos, F. Nogueira, V. R. Alves Pereira, M. D. C. Alves de Lima, I. J. da Cruz Filho   +10 more
semanticscholar   +1 more source

Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents

Chemistry Central Journal, 2018
Background The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium ...
Yahia N. Mabkhot, Mohammed M. Alharbi, Salim S. Al-Showiman, Hazem A. Ghabbour, Nabila A. Kheder, Saied M. Soliman, Wolfgang Frey   +6 more
doaj   +1 more source

Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study

BMC Chemistry, 2021
Background Thiazole-based Schiff base compounds display significant pharmacological potential with an ability to modulate the activity of many enzymes involved in metabolism.
Fitsum Lemilemu, Mamaru Bitew, T. Demissie, R. Eswaramoorthy, M. Endale   +4 more
semanticscholar   +1 more source

Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier

Біологія тварин, 2023
Many chemotherapeutics drugs have low water solubility, which potentially can decrease their anticancer potential. The use of drug delivery systems has proven to be highly effective in addressing the challenges associated with delivering hydrophobic ...
B. Omeliukh, Ya. Shalai, M. Bura, M. Ilkiv, Yu. Ostapiuk, N. Mitina, O. Zaichenko, A. Babsky   +7 more
doaj   +1 more source

Thiazoles in Peptides and Peptidomimetics [PDF]

, 2015
The natural occurrence of the thiazole ring in chemistry and biology has inspired its widespread use in synthetic peptidomimetics as structural templates, biological probes, and pharmaceuticals. Thiazole can be viewed as a dehydrated cyclized derivative of cysteine, incorporated into peptide sequences through chemical synthesis or ribosomal ...
Mak, Jeffrey Y. W., Xu, Weijun, Fairlie, David P.   +2 more
openaire   +3 more sources

Design, synthesis and docking studies of new hydrazinyl-thiazole derivatives as anticancer and antimicrobial agents

Journal of Saudi Chemical Society, 2022
Increase in the number of infections caused by pathogenic microbes in cancer patients has prompted the searcher to invest in the development of agents having dual anticancer and antimicrobial properties.
Abeer M El-Naggar, Alaa Zidan, E. Elkaeed, Mohammed S. Taghour, Waleed A Badawi   +4 more
semanticscholar   +1 more source