Results 21 to 30 of about 35,784 (226)

Synthesis, Anticancer and Antimicrobial Screening of New Naphthalenyl-Thiazole and Quinolinyl-Thiazole

, 2021
A new series of 4-aryl-2-(naphthalen-1-yl)thiazole (7a-b), 4-aryl/pyridyl-2-(2-substituted quinolin-4-yl)thiazole (13a-o) and 4-(pyridin-4-yl)-2-(quinolin-4-yl)thiazole (15) have been synthesized.
Yogita Abhale (11576400), Krishna Borde (11576397), Vivek Bobade (11576403), Pravin C. Mhaske (9857764), Yogesh Walunj (11576391), Abhijit Shinde (11576394)   +5 more
core   +1 more source

Thiazole-5-carbaldehyde Synthesis by Cascade Annulation of Enaminones and KSCN with Dess–Martin Periodinane Reagent

, 2022
The Dess–Martin periodinane (DMP) reagent-mediated reactions of tertiary enaminones with potassium thiocyanate for the synthesis of thiazole-5-carbaldehydes are developed.
Kang Chen (285159), Jie-Ping Wan (1393846), Yunyun Liu (538796), Baoli Zhao (1957888)   +3 more
core   +1 more source

Investigation of the In Vitro and In Silico Anticancer Potential of Novel 4-Arylthiazole-Hydrazone Derivatives. [PDF]

Chem Biol Drug Des
The synthesized compounds exhibited excellent cytotoxicity on MCF‐7, breast cancer cell line with selective profile especially 2d with IC50 value of 0.12 μM. Three compounds 2c, 2d, and 2h caused almost as much apoptosis induction as cisplatin. Compound 2d exhibited caspase‐3 activation at standard drug level.
Demirci ZZ, Akgün E, Çiftçi GA, Yurttaş L.   +3 more
europepmc   +2 more sources

First method for dissolving zinc thiazole and re-evaluation of its antibacterial properties against rice bacterial blight disease

Phytopathology Research, 2019
Rice bacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo), is one of the most destructive diseases in rice-growing regions worldwide. Zinc thiazole is a novel bactericide and has been applied for BB control for 10 years.
Xian Chen, Lan Zhou, Pedro Laborda, Yancun Zhao, Kaihuai Li, Fengquan Liu   +5 more
doaj   +1 more source

Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents

Journal of Saudi Chemical Society, 2023
A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and their chemical structures were confirmed by spectral data (infrared, 1H & 13C NMR and Mass).
Gadeer R.S. Ashour, Ahmad Fawzi Qarah, Abdulmajeed F. Alrefaei, Adel I. Alalawy, Amerah Alsoliemy, Alaa M. Alqahtani, Wael M. Alamoudi, Nashwa M. El-Metwaly   +7 more
doaj   +1 more source

Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents

Chemistry Central Journal, 2018
Background The synthesis of new thiazole derivatives is very important because of their diverse biological activities. Also , many drugs containing thiazole ring in their skeletons are available in the market such as Abafungin, Acotiamide, Alagebrium ...
Yahia N. Mabkhot, Mohammed M. Alharbi, Salim S. Al-Showiman, Hazem A. Ghabbour, Nabila A. Kheder, Saied M. Soliman, Wolfgang Frey   +6 more
doaj   +1 more source

Activity of antioxidant enzymes in hepatocytes of mice with lymphoma under the action of thiazole derivative in complex with polymeric nanocarrier

Біологія тварин, 2023
Many chemotherapeutics drugs have low water solubility, which potentially can decrease their anticancer potential. The use of drug delivery systems has proven to be highly effective in addressing the challenges associated with delivering hydrophobic ...
B. Omeliukh, Ya. Shalai, M. Bura, M. Ilkiv, Yu. Ostapiuk, N. Mitina, O. Zaichenko, A. Babsky   +7 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Anthracene Derivatives as Potent Antioxidants: Experimental, DFT, and Docking Studies. [PDF]

Chem Biol Drug Des
A series of anthracene‐based derivatives exhibited exceptional antioxidant activity, with IC50 values surpassing ascorbic acid. DFT and molecular docking studies revealed efficient charge transfer and strong Keap1/Nrf2 binding, highlighting their potential as promising therapeutic agents against oxidative stress.
Elmorsy MR, Moustafa M, Etman HA, El-Metwaly NM, Badawy SA.   +4 more
europepmc   +2 more sources

Demethylation and desulfonation of textile industry dye, Thiazole Yellow G by Aspergillus niger LAG

Biotechnology Reports, 2019
Filamentous fungi perform tremendously in adsorption of dyes from polluted environment. In this study, Aspergillus niger LAG decolorized thiazole yellow G dye within 5 days. Scale up studies done revealed that maximum decolorization (98%) was achieved at
Paul O. Bankole, Adedotun A. Adekunle, Sanjay P. Govindwar   +2 more
doaj   +1 more source

Synthesis of camphor thiazole derivates from Dryobalanops aromatica and its bioactivity as antioxidants and antidiabetes against alpha glucosidase enzymes

MethodsX, 2023
Camphor is synthesized from the Sumatran camphor plant (Dryobalanops aromatica) in previous experiments. It can be synthesized with thiosemicarbazide, ethy-2‑chloro acetoacetate, and sodium acetate (catalyze) to form camphor derivate with thiazole ring ...
Antonius Herry Cahyana, Gusman Santika, Kandarpa Phukan   +2 more
doaj   +1 more source