Results 191 to 200 of about 424,053 (243)

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

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Organization of myosin molecules in the muscle thick filament

Experientia, 1976
Tryptic treatment of muscle thick filaments reveals the underlying backbones of aggregatedl-meromyosin as a coli of 3 secondary filaments (helical repeat ∼ 130 nm) each in turn a coli of a 3 finer ones.
C L, Davey, A E, Graafhuis
exaly   +3 more sources

Muscle Mechanics and Thick Filament Activation: An Emerging Two-Way Interaction for the Vertebrate Striated Muscle Fine Regulation [PDF]

International Journal of Molecular Sciences, 2023
Contraction in striated muscle is classically described as regulated by calcium-mediated structural changes in the actin-containing thin filaments, which release the binding sites for the interaction with myosin motors to produce force.
Lorenzo Marcucci
exaly   +2 more sources

Bipolarity in thick filaments of Nematomorpha

Journal of Molecular Biology, 1977
Thick filaments of horse-hair worms muscles are characterized by asymmetrical periods 670 to 700 A long. A reversal zone, with centro-symmetrical periods has been observed; therefore these filaments are bipolar, as required for the sliding filament contraction mechanism.
G, Lanzavecchia, R, Valvassori, M, De Egiuleor   +2 more
openaire   +2 more sources

Thick filaments in vertebrate smooth muscle

Cell and Tissue Research, 1975
Smooth muscle cells of the mouse vas deferens fixed with 5% glutaraldehyde contained three types of filaments, namely, thin (50-80) A) filaments, intermediate (100 A) filaments and thick (120-180 A) filments. However, in 2 out of 16 experiments, under identical conditions, the cells did not contain thick filaments.
Campbell, GR, Chamley, JH
openaire   +4 more sources

Electron microscopy of nematode thick filaments

Journal of Ultrastructure Research, 1981
Thick filaments have been isolated from the body-wall muscle cells of the nematode, Caenorhabditis elegans. Their protein constituents were shown by SDS—polyacrylamide gel electrophoresis to be myosin, paramyosin, several previously unidentified protein bands and small amounts of actin and tropomyosin from contaminating thin filaments.
J M, MacKenzie, H F, Epstein
openaire   +2 more sources

Thick Filament Diseases

2008
Hereditary myosin myopathies are a newly emerged group of diseases caused by mutations in skeletal muscle myosin heavy chain (MyHC) genes. The phenotypes of these diseases are varied, ranging from prenatal nonprogressive arthrogrypotic syndromes to adult-onset progressive muscle weakness.
Anders, Oldfors, Phillipa J, Lamont
openaire   +2 more sources

Thick filaments and paramyosin of annelid muscles

Journal of Ultrastructure Research, 1976
Thick filaments from annelid muscle were observed by positive and negative staining of the glycerinated sample, which was homogenized in a relaxing medium containing ATP. The preservation of myosin on the filament surface was strictly related to very high concentration of ATP (12 m M .). The 144 A periodicity was scarcely visible.
M, Camatini, L C, Castellani, E, Franchi, G, Lanzavecchia, L, Paoletti   +4 more
openaire   +2 more sources