Results 251 to 260 of about 1,111,006 (279)
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Molecular arrangement of troponin-tropomyosin in the thin filament
Advances in Biophysics, 1982Clarification of molecular arrangement of three troponin components in the thin filament is one of the essential problems in the field of the calcium regulation of muscle contraction. This review aims at discussing the present status of our structural studies of these Ca receptive proteins. Particular attention was rapid to the role of troponin T which
I, Ohtsuki, K, Nagano
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Investigations into the Pathobiology of Thin-Filament Myopathies
2008Mutations in actin and tropomyosin, identified in patients with myopathic disease have been used in tissue culture models and functional studies with a view to understand how these mutations impact on skeletal muscle structure and function and result in muscle weakness.
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Models of Thin-Filament Regulation
2018While the strength of contraction in our muscles is activated by the frequency of action potentials in its efferent nerves, this chapter is concerned with the way in which calcium ions released by the transverse-tubule system regulate contraction via the thin filament.
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Thin Filament Structure and Regulation
1981Actin must rank as one of the most ubiquitous proteins in nature. Thin filaments consisting largely of actin molecules have been found to occur in all of the different muscle types that have so far been studied. In addition, actin molecules with virtually identical properties to those in muscle have been found in a variety of non muscle cells, ranging ...
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Thin Filament-Mediated Regulation of Cardiac Contraction
Annual Review of Physiology, 1996Cardiac and skeletal muscle contraction are activated by Ca2+ binding to specific regulatory sites on the striated muscle thin filament. The thin filament is a large allosteric assembly, containing multiple copies of actin, tropomyosin, and the three troponin subunits (troponin C, troponin I, and troponin T).
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Thin Filament Regulation in Development
2002The basic function of the heart is to eject blood. This function is supported throughout development by the sarcomere and the interaction of its thick and thin filaments. In the face of this constancy, the ability of the heart to work, modulate its output, and respond to pathophysiologic states undergoes marked changes with development.
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Thin Filament Structure and the Steric Blocking Model
Comprehensive Physiology, 2016ABSTRACT By interacting with the troponin‐tropomyosin complex on myofibrillar thin filaments, Ca 2+ and myosin govern the regulatory switching processes influencing contractile activity of mammalian cardiac and skeletal muscles.
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The structure of the native cardiac thin filament at systolic Ca2+ levels
Proceedings of the National Academy of Sciences of the United States of America, 2021José Renato Pinto +2 more
exaly