Guanine derivatives as promising candidates for the development of purine-based antimalarial drugs [PDF]
Frontiers in ParasitologyIntroductionThe increasing resistance of Plasmodium falciparum to existing antimalarial drugs drives the urgent need for novel therapeutic strategies. The purine salvage pathway in P.
Worlanyo Tashie +6 more
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The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study [PDF]
Therapeutic Advances in GastroenterologyBackground: Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines.
Helena Gensmyr-Singer +2 more
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Pharmacological evaluation of drug therapies in Aicardi-Goutières syndrome: insights from patient-derived neural stem cells [PDF]
Frontiers in PharmacologyAicardi-Goutières syndrome (AGS) is a rare genetic disorder classified among type I interferonopathies. Current pharmacological management of AGS is symptomatic and supportive, with recent clinical applications of JAK inhibitors (JAKi) and antiretroviral
Stefania Braidotti +18 more
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Tạp chí Khoa học Đại học Cần Thơ, 2022 Các phép tính DFT (lý thuyết hàm mật độ) được sử dụng để làm sáng tỏ bản chất của quá trình hấp phụ các phân tử thuốc mercaptopurine (MP) và thioguanine (TG) trên bề mặt vàng, sử dụng Au6 cluster làm mô hình phản ứng.
Nguyễn Thị Nhật Hằng +4 more
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Use of laser-triggered gold nanoparticle-grafted dual light and temperature-responsive polymeric sensor for the recognition of thioguanine as anti-tumor agent [PDF]
Nanomedicine Journal, 2020 Objective(s): Today, there is an urgent need for improved sensor materials for drug sensing and effective monitoring and interventions in this area are highly required to struggle drug abuse. The present study aimed to synthesize a thioguanine-responsive
Kamyar Pourghazi +2 more
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Haematologica, 2021 Maintenance therapy containing methotrexate and 6-mercapto - purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is ...
Rikke Hebo Larsen +17 more
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Scientific Reports, 2023 6-Thioguanine is an immunosuppressive drug, an analogue of guanine, applied to treat acute leukemia and inflammatory bowel disease. Excessive use of 6-thioguanine during clinical treatment may cause side effects.
Maciej Noga +5 more
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Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease
Toxics, 2022 The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) was confirmed more than a half-century ago. It was proven that these can be essential immunomodulatory medications.
Oliwia Zakerska-Banaszak +5 more
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Au Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery [PDF]
Journal of Nanostructures, 2018 In this study we suggested a new strategy for drug delivery of 6-thioguanine (6-TG) as a cancer drug by loading of this thiolic drug at a surface of Au nanoparticles. For this goal, we synthesized Au nanoparticle (Au/NPs) by reduction of tetrachloroauric
Hassan Karimi-Maleh +4 more
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Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway
Frontiers in Oncology, 2020 Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies.
Daoyu Zhang +9 more
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