Results 11 to 20 of about 14,774 (209)

Pharmacogenomics of Thiopurine Drugs: A Bench-To-Bedside Success Story in Thailand. [PDF]

Clin Transl Sci
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Biswas M, John S, Murad MA, Sukasem C.
europepmc   +2 more sources

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels. [PDF]

Br J Clin Pharmacol
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Suarez-Kurtz G.
europepmc   +2 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Comparison of the use of 6-thioguanine riboside versus 6-thioguanine as calibration standard to monitor 6-thioguanine nucleotides in red blood cells

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
The analytical methods reported to evaluate 6-Thioguanine nucleotides (6-TGNs) level in red blood cells (RBC) are based on the conversion of 6-TGNs to 6-Thioguanine (6-TG) using 6-thioguanine as calibration standard.Using the LC-DAD method previously ...
Roselyne Boulieu, Antoine Tourlonias, Magali Larger   +2 more
doaj   +1 more source

Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode

Journal of Electrochemical Science and Engineering, 2021
A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method.
Fatemeh Irannezhad, Jamileh Seyed-Yazdi, Seyedeh Hoda Hekmatara   +2 more
doaj   +1 more source

Adverse Reactions to Drugs of Special Interest in a Pediatric Oncohematology Service

Frontiers in Pharmacology, 2021
Introduction: Drugs used in oncological diseases are frequently related to adverse drug reactions (ADR). Few studies have analyzed the toxicity of cancer treatments in children in real practice.Methods: An observational, longitudinal and prospective ...
Kristopher Amaro-Hosey, Kristopher Amaro-Hosey, Immaculada Danés, Immaculada Danés, Immaculada Danés, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Alonso, Laura Alonso, Berta Renedo, Luis Gros, Luis Gros, Xavier Vidal, Xavier Vidal, Xavier Vidal, Gloria Cereza, Gloria Cereza, Gloria Cereza, Antònia Agustí, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment. [PDF]

Clin Transl Sci
ABSTRACT The nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S‐methyltransferase (TPMT) variants.
Khaeso K, Chainansamit SO, Kuwatjanakul P, Komvilaisak P, Nakkam N, Suwannaying K, Vannaprasaht S, Dornsena A, Tassaneeyakul W.   +8 more
europepmc   +2 more sources

Unrealized potential of drug repositioning in Europe during COVID-19 and beyond: a physician’s perspective

Journal of Pharmaceutical Policy and Practice, 2020
Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. The advantages of drug repositioning are that it benefits patients and that it adds new indications to existing drugs for lower costs ...
A. B. Bayoumy, N. K. H. de Boer, A. R. Ansari, F. Crouwel, C. J. J. Mulder   +4 more
doaj   +1 more source

Thiopurine metabolite levels in patients with atopic dermatitis and/or chronic hand/foot eczema treated with azathioprine [PDF]

, 2017
Background: Azathioprine is frequently used in severe eczema. It is converted in the liver into active metabolites, including 6-thioguanine nucleotide (6-TGN) and methylated 6-methylmercaptopurine (6-MMP).
Broek, M.P.H. (Marcel) van den, Bruijnzeel-Koomen, C.A., Bruin-Weller, M.S. (M.) de, de Graaf, M. (M.), Garritsen, F.M. (F. M.), Schaik, R.H.N. (Ron) van, Van Der Schaft, J.   +6 more
core   +7 more sources

Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising “MINT” sequencing strategy and therapeutic “DNA-TG” monitoring

Frontiers in Pharmacology, 2022
Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo, Yue-Tao Zhao, Yue-Tao Zhao, Wei-Jun Wang, Wei-Jun Wang, Na Dong, Na Dong, Ya-Hui Hu, Yuan-Yuan Zhang, Feng Chen, Li Zhou, Tao Li   +11 more
doaj   +1 more source