Results 31 to 40 of about 14,774 (209)
Heliyon, 2023 A rapid, specific and accurate high-performance liquid chromatography with tunable ultraviolet detection method was developed to simultaneously determine azathioprine metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methyl mercaptopurine riboside (6 ...
Hengyi Yu +6 more
doaj +1 more source
Autopsy and Case Reports, 2017 The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a
Ana Luiza Vilar Guedes +7 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD).
Yong Hua Sheng +17 more
doaj +1 more source
Bvr-1, a Restriction Locus of a Type C RNA Virus in the Feline Cellular Genome: Pleiotropic Restriction of Endogenous BALB Virus in Cat x Mouse Somatic Cell Hybrids [PDF]
, 1978 Bvr-1 is a dominant X-linked feline gene which restricts the replication of B-tropic murineleukemia virus (B-MuLV) in somatic cell hybrids between murine BALB/c-RAG cells and FL-74 feline cells.
O\u27Brien, Stephen J. +1 more
core +2 more sources
6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes
Microbiology Spectrum, 2021 Herpes simplex virus 1 (HSV-1) infects eye corneal tissues leading to herpetic stromal keratitis (HSK), which is one of the leading causes of blindness.
Deyan Chen +6 more
doaj +1 more source
Inflammation, DNA-centered radicals, and oxidative genotoxicity: The role of HOCl produced by myeloperoxidase in carcinogenesis [PDF]
, 2009 Myeloid cells (macrophages and neutrophils) infiltrate and synthesize myeloperoxidase (MPO) in sites of inflammation, producing gentotoxicity. In RAW 264.7 macrophages, bacterial lipopolysaccharide (LPS) induces superoxide radical anion, nuclear ...
Dario C. Ramirez +2 more
core +2 more sources
Molecules, 2017 6-Thioguanine, an immunosuppressant and anticancer prodrug, has been shown to induce DNA damage and cell death following exposure to UVA radiation. Its metabolite, 6-thioguanosine, plays a major role in the prodrug’s overall photoreactivity.
Brennan Ashwood +2 more
doaj +1 more source
Pharmacogenomics and Personalized Medicine, 2021 Dewi Selvina Rosdiana,1 Rianto Setiabudy,1 Rizka Andalusia,2,3 Djajadiman Gatot,4 Melva Louisa,1 Saptawati Bardosono,5 Instiaty Instiaty1 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia ...
Rosdiana DS +6 more
doaj
Excited State Dynamics of 6-Thioguanine [PDF]
The Journal of Physical Chemistry A, 2017 Here we present the excited state dynamics of jet-cooled 6-thioguanine (6-TG), using resonance-enhanced multiphoton ionization (REMPI), IR-UV double resonance spectroscopy, and pump-probe spectroscopy in the nanosecond and picosecond time domains. We report data on two thiol tautomers, which appear to have different excited state dynamics.
Siouri, Faady M +3 more
openaire +4 more sources
Role of Oxidative Stress Mediated by Glutathione-S-transferase in Thiopurines' Toxic Effects [PDF]
, 2015 Azathioprine (AZA), 6-mercaptopurine (6-MP), and 6-thioguanine (6-TG) are antimetabolite drugs, widely used as immunosuppressants and anticancer agents.
De Iudicibus, Sara +9 more
core +1 more source