Results 61 to 70 of about 14,774 (209)

In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis

Indonesian Biomedical Journal, 2021
BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG ...
Nurul Syuhada Nordin, Yong Yoke Keong, Siti Farah Md Tohid, Zetty Nadia Md Zain, Muhammad Nazrul Hakim   +4 more
doaj   +1 more source

Theoretical insights into the interaction of 6-Thioguanine anticancer drug with β-Cyclodextrin as a pharmaceutical Nanocarrier via density functional theory

Results in Chemistry
In this study, the absorption and interaction effects of the anticancer drug 6-Thioguanine in various orientations on the β-cyclodextrin nanocarrier were theoretically investigated and optimized using Gaussian 09 software. Quantum mechanical calculations,
Sepideh Shokri Shams, Masoumeh Shahi, Fatemeh Azarakhshi   +2 more
doaj   +1 more source

The first cases of collagenous sprue successfully treated with thioguanine

BMJ Open Gastroenterology, 2016
Objective Collagenous sprue (CS) is a rare form of small bowel enteropathy characterised by a thickened basement membrane and is, in most of the literature, reported as part of coeliac disease. Multiple treatment strategies are suggested in CS, but there
Chris J J Mulder, Gerd Bouma, Tom van Gils, Tine van de Donk, Foke van Delft, E Andra Neefjes-Borst   +5 more
doaj   +1 more source

Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED, MANALK RASHEED, HASANEIN H GHALI   +2 more
doaj   +1 more source

Coulometric Determination of Sulphur Compounds Using the Induced lodine-Azide Reaction [PDF]

, 2004
Wydrukowano z dostarczonych Wydawnictwu UŁ gotowych materiałówThe review summarizes application of coulometry for determination of the sulphur compounds that induce the iodine-azide reaction.
Ciesielski, Witold
core  

Genetic Screens in Human Cells Using the CRISPR-Cas9 System [PDF]

, 2013
The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, enabling the rapid generation of isogenic cell lines and mice with modified alleles ...
Lander, Eric Steven, Sabatini, David, Wang, Tim, Wei, Jenny J.   +3 more
core   +1 more source

Additives for Aluminum‐Air Batteries: A Review

Small, EarlyView.
The role of electrolyte additives in Al–air batteries is investigated by focusing on their capacity to moderate Al corrosion rates, inhibit self‐discharge, and prevent surface barrier formation. Additives present in organic, inorganic, and hybrid categories, which regulate the Al–electrolyte interface by forming protective films on the Al surface ...
Hajar Mahmoudi, Asrar Alam, Patrick Theato, Maria Felicia Gaele, Pasquale Gargiulo, Huijing Li, Tonia Mariarosaria Di Palma   +6 more
wiley   +1 more source

EPIDEMIOLOGY OF THERAPY-RELATED MYELOID NEOPLASMS IN THE NORDIC COUNTRIES

Mediterranean Journal of Hematology and Infectious Diseases, 2011
Of 1614 Nordic children with ALL that were treated according to the NOPHO ALL92 protocol, 20 developed an SMN (cumulative risk at 12 years: 1.6%). Sixteen of the twenty SMNs were acute myeloid leukemias or myelodysplasias, and 9 of these had either ...
Kjeld Schmiegelow
doaj   +1 more source

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro

iScience, 2021
Summary: The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics.
Caleb D. Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa A. Canadeo, Houda H. Harastani, Tamarand L. Darling, Adrianus C.M. Boon, Deborah J. Lenschow, Viraj Kulkarni, Jon M. Huibregtse   +10 more
doaj   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source