Results 91 to 100 of about 221,664 (312)
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Cytochrome C Biosensor—A Model for Gas Sensing
Sensors, 2011 This work is about gas biosensing with a cytochrome c biosensor. Emphasis is put on the analysis of the sensing process and a mathematical model to make predictions about the biosensor response.
Gabriele Nelles +3 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report
Andrea Medeiros +11 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal +7 more
wiley +1 more source
Cellulose Sulfuric Acid: As an Efficient Bio Polymer Based Catalyst for the Selective Oxidation of Sulfides and Thiols by Hydrogen Peroxide [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2014 Cellulose sulfuric acid as a bio-polymer based solid catalyst efficiently catalyzes the selectively oxidation of sulfides to sulfoxides and thiols to disulfides using hydrogen peroxide as a green oxidant with good yields at room temperature.
Ahmad Shaabani +3 more
doaj
Transcriptomic and Proteomic Tools in the Study of Hg Toxicity: What Is Missing?
Frontiers in Genetics, 2020 Mercury is a hazardous substance that has unique neurodevelopmental toxic effects in humans. However, the precise sequence of molecular events that culminate in Hg-induced neuropathology is still unknown.
Cláudia S. Oliveira +8 more
doaj +1 more source
, 2017 Bacterial contamination of surfaces and the associated infection risk is a significant threat to human health. Some natural antibacterial polymers with low toxicity are promising coating materials for alleviating pathogenic colonization on surfaces ...
Min Li (12799) +5 more
core +1 more source
Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation
Advanced Healthcare Materials, EarlyView.This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad +7 more
wiley +1 more source
Oxidative modification of proteins: An emerging mechanism of cell signaling
Frontiers in Physiology, 2012 There are a wide variety of reactive species which can affect cell function, including reactive oxygen, nitrogen, and lipid species. Some are formed endogenously through enzymatic or non-enzymatic pathways, and others are introduced through diet or ...
Stephanie B. Wall +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină +2 more
wiley +1 more source