Results 141 to 150 of about 5,819 (161)

Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy

Clinical Biochemistry, 2004
Standardization of thiopurine metabolite testing is currently lacking. This paper presents in-depth methodological analysis and optimization of two currently available HPLC procedures (Lennard-Singleton [J. Chromatogr. 583 (1992) 83] and Dervieux-Boulieu [Clin. Chem.
Cristiana, Stefan, Warren, Walsh, Tibor, Banka, Khosrow, Adeli, Zulfikarali, Verjee   +4 more
openaire   +2 more sources

Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD

Journal of Pediatric Gastroenterology and Nutrition, 2013
ABSTRACTThiopurines have been used in inflammatory bowel disease (IBD) for >30 years, and measurements of both thiopurine methyltransferase (TPMT) and thiopurine (TP) metabolites, 6‐thioguanine nucleotides (6‐TGN) and 6‐methylmercaptopurine (6‐MMP), have been readily available.
Keith, Benkov, Ying, Lu, Ashish, Patel, Riad, Rahhal, Gary, Russell, Jonathan, Teitelbaum   +5 more
openaire   +2 more sources

No Induction of Thiopurine Methyltransferase During Thiopurine Treatment in Inflammatory Bowel Disease

Nucleosides, Nucleotides and Nucleic Acids, 2006
The aim of this study was to follow, during standardized initiation of thiopurine treatment, thiopurine methyltransferase (TPMT) gene expression and enzyme activity and thiopurine metabolite concentrations, and to study the role of TPMT and ITPA 94C > A polymorphisms for the development of adverse drug reactions.
M, Lindqvist, U, Hindorf, S, Almer, P, Söderkvist, M, Ström, H, Hjortswang, C, Peterson   +6 more
openaire   +2 more sources

Intrauterine exposure to thiopurines

Reproductive Toxicology, 2012
Jharap, B., Seinen, M.L., van Bodegraven, A.A., de Boer, K.H.N.   +3 more
openaire   +3 more sources

Thiopurines

2010
Terreia S. Jones, Mary V. Relling
openaire   +1 more source

Thiopurines best practice

Journal of Gastroenterology and Hepatology, 2016
openaire   +2 more sources

6-Thiopurines

1975
A. R. P. Paterson, D. M. Tidd
openaire   +1 more source

Polyribonucleotides containing thiopurines

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
Venkataraman Amarnath, Arthur D. Broom
openaire   +1 more source

Allopurinol/thiopurines

Reactions Weekly, 2011
openaire   +1 more source

Why thiopurine metabolites are relevant

Alimentary Pharmacology & Therapeutics, 2012
A B, Friedman, M P, Sparrow, P R, Gibson
openaire   +2 more sources