Results 91 to 100 of about 19,795 (176)

Effect of Thioredoxin Deletion and p53 Cysteine Replacement on Human p53 Activity in Wild-Type and Thioredoxin Reductase Null Yeast

, 2016
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene transactivation by p53 was ...
Christopher S. Stoner (2348095), George D. Pearson (2348104), Nathan I. Lopez (2348101), Jason R. Merwin (2348092), Ahmet Koç (2348098), Gary F. Merrill (262243)   +5 more
core   +1 more source

Fluorogenic Probes for Thioredoxin Reductase Activity

, 2021
The thioredoxin system is vital in maintaining the cellular redox state and is implicated in various cancers and other diseases. It comprises of thioredoxin reductase, thioredoxin and NADPH.
Jorge O. Escobedo, Tendai J. Mafireyi, Robert M. Strongin, Mafireyi, Tendai J., Escobedo, Jorge O., Strongin, Robert   +5 more
core   +1 more source

Synergism between a foldase and an unfoldase: Reciprocal dependence between the thioredoxin-like activity of DnaJ and the polypeptide-unfolding activity of DnaK

Frontiers in Molecular Biosciences, 2014
The role of bacterial Hsp40, DnaJ, is to co-chaperone the binding of misfolded or alternatively folded proteins to bacterial Hsp70, DnaK, which is an ATP-fuelled unfolding chaperone.
Rayees Ul Hassan Mattoo, America eFarina Henriquez Cuendet, Subbanna eSujatha, Andrija eFinka, Smriti ePriya, Sandeep Kumar Sharma, Pierre eGoloubinoff   +6 more
doaj   +1 more source

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

PLoS Pathogens, 2019
Most known thioredoxin-type proteins (Trx) participate in redox pathways, using two highly conserved cysteine residues to catalyze thiol-disulfide exchange reactions.
Rachel B Currier, Kathrin Ulrich, Alejandro E Leroux, Natalie Dirdjaja, Matías Deambrosi, Mariana Bonilla, Yasar Luqman Ahmed, Lorenz Adrian, Haike Antelmann, Ursula Jakob, Marcelo A Comini, R Luise Krauth-Siegel   +11 more
doaj   +1 more source

Perturbation of Cytochrome c Maturation Reveals Adaptability of the Respiratory Chain in Mycobacterium tuberculosis

mBio, 2013
Mycobacterium tuberculosis depends on aerobic respiration for growth and utilizes an aa3-type cytochrome c oxidase for terminal electron transfer. Cytochrome c maturation in bacteria requires covalent attachment of heme to apocytochrome c, which occurs ...
Jennifer L. Small, Sae Woong Park, Bavesh D. Kana, Thomas R. Ioerger, James C. Sacchettini, Sabine Ehrt   +5 more
doaj   +1 more source

Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]

, 2012
Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara, Hauck Stefanie M., Kerstin N. Euler, Barbara Amann, Dorsch Roswitha, Euler, K.N., Cornelia A Deeg, Dorsch, Roswitha, Roswitha Dorsch, Kerstin N Euler, Euler Kerstin N., Deeg Cornelia A., Amann Barbara, Treutlein, Gudrun, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Treutlein Gudrun, Hauck, Stefanie M., Euler, Kerstin N., Cornelia A. Deeg, Amann, B., Hartmann, Katrin, Hartmann Katrin, Hauck, S.M., Hartmann, K., Katrin Hartmann, Treutlein, G., Gudrun Treutlein, Deeg, C.A., Dorsch, R.   +30 more
core   +1 more source

Characterising the expression and interactions of the Endoplasmic Reticulum Oxidoreductase Erol β [PDF]

, 2006
Proteins destined for the secretory pathway and endoplasmic reticulum (ER) resident proteins are targeted to the ER through an N-terminal signal sequence. Proteins then follow a post-translational maturation process to fold into functional proteins.
Gunasekara, Sanjika Dias
core  

Biochemical Characterization of the Thioredoxin Reductase from Babesia bovis

, 2014
This paper addresses the identification, cloning, expression, purification and functional characterization of thioredoxin reductase from Babesia bovis, the etiological agent of babesiosis.
Guerrero, Sergio Adrian, Thompson, Carolina S., Arias, Diego Gustavo, Iglesias, Alberto Alvaro, Thompson, Carolina Soledad, Regner, Erika Lucía   +5 more
core   +1 more source

Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stress

, 2004
In this report we describe the cloning, organization, and promoter analysis of the Staphylococcus aureus thioredoxin (trxA) and thioredoxin reductase (trxB) genes and their transcription in response to changes in oxygen concentration and to oxidative ...
Gerald Cohen, Yair Aharonowitz, Orit Uziel, Rachel Schreiber, Ilya Borovok   +4 more
core  

The 58 kDa mouse selenoprotein is a BCNU-sensitive thioredoxin reductase

, 1997
The flavoprotein thioredoxin reductase [EC 1.6.4.5] (NADPH+H++thioredoxin-S2→NADP++thioredoxin-(SH)2) was isolated from mouse Ehrlich ascites tumour (EAT) cells.
Katja Becker, Stephan Gromer, Becker, Katja, R.Heiner Schirmer, Gromer, Stephan, Schirmer, R.Heiner   +5 more
core   +1 more source