Results 1 to 10 of about 46,151 (247)

Role of thioredoxin reductase (TrxB) in oxidative stress response of Francisella tularensis live vaccine strain [PDF]

Journal of Bacteriology
Francisella tularensis is an important human pathogen responsible for causing tularemia in the Northern Hemisphere. Francisella has been developed as a biological weapon in the past due to its extremely high virulence. F.
Matthew Higgs, Zhuo Ma, Anthony Centone, Chandra Shekhar Bakshi, Meenakshi Malik   +4 more
doaj   +2 more sources

Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences [PDF]

Insects
Increased levels of reactive oxygen species (ROS) produced during aerobic metabolism in animals can negatively affect the intracellular redox status, cause oxidative stress and interfere with physiological processes in the cells.
Andrea Gřešková, Marek Petřivalský
doaj   +2 more sources

STEM-08. OVERCOMING GLIOBLASTOMA STEM CELL RESISTANCE TO RADIATION THROUGH TARGETING THIOREDOXIN REDUCTASE 1 [PDF]

Neuro Oncol, 2023
Fatemeh Jamali, Katherine Lan, Siham Sabri, Bassam Abdulkarim   +3 more
europepmc   +3 more sources

Structure-based identification of a non-covalent thioredoxin reductase inhibitor with proven ADMET suitability. [PDF]

J Enzyme Inhib Med Chem
Lamanna G, Augello G, Ronga L, Tesauro D, Silvestri I, Azzolina A, Cervello M, Mangiatordi GF, Saviano M.   +8 more
europepmc   +2 more sources

Simulating the Motion Underlying the Mechanism of Thioredoxin Reductase. [PDF]

ACS Omega
Zuiderweg ERP, Case DA, Williams CH.
europepmc   +3 more sources

Supramolecular Efficient Catalysis for Multicomponent Synthesis of Fused Indeno-pyrido[2,3‑<i>d</i>]pyrimidines as <i>Staphylococcal Thioredoxin Reductase</i> (<i>Sa</i>TrxR) Inhibitor Leads. [PDF]

ACS Omega
Bhosle MR, Belambe AV, Yadav VK, Bhati AS, Talekar SS, Bondle GM, Mane MV, Bhattacharyya S.   +7 more
europepmc   +2 more sources

Thioredoxin reductase [PDF]

Biochemical Journal, 2000
The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a conserved -Cys-Val-Asn-Val-Gly-Cys- redox catalytic site, to glutathione reductases.
D, Mustacich, G, Powis
openaire   +5 more sources

Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity

Antioxidants, 2023
Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes that protect organisms from oxidative stress. These proteins also play roles in redox signaling and can act as a redox-independent cellular chaperone.
Abdelrahman AlOkda, Jeremy M. Van Raamsdonk   +1 more
doaj   +1 more source

Fluorogenic probes for thioredoxin reductase activity

Results in Chemistry, 2021
The thioredoxin system is vital in maintaining the cellular redox state and is implicated in various cancers and other diseases. It comprises of thioredoxin reductase, thioredoxin and NADPH.
Tendai J. Mafireyi, Jorge O. Escobedo, Robert M. Strongin   +2 more
doaj   +1 more source

JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. [PDF]

PLoS ONE, 2010
The selenoenzyme thioredoxin reductase 1 has a complex role relating to cell growth. It is induced as a component of the cellular response to potentially mutagenic oxidants, but also appears to provide growth advantages to transformed cells by inhibiting
Kornelia Edes, Pamela Cassidy, Paul J Shami, Philip J Moos   +3 more
doaj   +1 more source