Results 11 to 20 of about 46,151 (247)

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition. [PDF]

PLoS ONE, 2016
BACKGROUND:The entry of HIV into its host cell is an interesting target for chemotherapeutic intervention in the life-cycle of the virus. During entry, reduction of disulfide bridges in the viral envelope glycoprotein gp120 by cellular oxidoreductases is
Kathrin Reiser, Leen Mathys, Sophie Curbo, Christophe Pannecouque, Sam Noppen, Sandra Liekens, Lars Engman, Mathias Lundberg, Jan Balzarini, Anna Karlsson   +9 more
doaj   +1 more source

Tissue Distribution and Activity of Thioredoxin Reductase in Pancreatic Carcinoma [PDF]

Middle East Journal of Cancer, 2019
Background: Thioredoxin, NADPH, and thioredoxin reductase form the thioredoxinsystem which exists in all living cells. Oxidants have a major role in cancer pathogenesis;therefore, it is necessary to study the role of redox-active compounds such as ...
Faezeh Sadrabadi Haghighi, Mohsen Aliakbarian, Alireza Khooei, Seyed Isaac Hashemy   +3 more
doaj   +1 more source

The over expression of thioredoxin during malignancies [PDF]

Reviews in Clinical Medicine, 2014
Thioredoxin system comprised of thiorexin and NADPH dependent thiorexin reductase, is responsible for redox regulation of cells by controlling the apoptosis, proliferation and other vital processes of cells.
Shahaboddin Shabani, Navid Nourizadeh, Mohammadsaleh Soltankhah   +2 more
doaj   +3 more sources

Molecular docking studies of N-Heterocyclic Carbene molecules with Thioredoxin Reductase and DNA

Cumhuriyet Science Journal, 2021
Thioredoxin which is induced by thioredoxin reductase causes the proliferation of cancerous cells and metastasis due to its effects on cell growth, besides its regulatory effects on the amount of reactive oxygen species.
Elvan Üstün, Neslihan Şahin
doaj   +1 more source

Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase. [PDF]

PLoS Biology, 2007
Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with microaerophilic protist parasites, including Entamoeba histolytica. For activation, the drug must be chemically reduced, but little
David Leitsch, Daniel Kolarich, Iain B H Wilson, Friedrich Altmann, Michael Duchêne   +4 more
doaj   +1 more source

Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease. [PDF]

PLoS ONE, 2014
Understanding how pathogenic fungi adapt to host plant cells is of major concern to securing global food production. The hemibiotrophic rice blast fungus Magnaporthe oryzae, cause of the most serious disease of cultivated rice, colonizes leaf cells ...
Jessie Fernandez, Richard A Wilson
doaj   +1 more source

Physiological functions of thioredoxin and thioredoxin reductase [PDF]

European Journal of Biochemistry, 2000
Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. Thioredoxins, with a dithiol/disulfide active site (CGPC) are the major cellular protein disulfide reductases; they therefore also serve as electron donors for enzymes such as ribonucleotide reductases, thioredoxin peroxidases (peroxiredoxins) and ...
E S, Arnér, A, Holmgren
openaire   +2 more sources

Lipoamide Dehydrogenase, Glutathione Reductase, Thioredoxin Reductase, and Thioredoxin

Journal of Biological Chemistry, 1967
Abstract A procedure has been developed for the purification of lipoamide dehydrogenase, glutathione reductase, thioredoxin reductase, and thioredoxin from Escherichia coli B, in which the four proteins are purified together in the initial stages separation effected in two steps, and the individual purifications completed in one or two steps.
C H, Williams, G, Zanetti, L D, Arscott, J K, McAllister   +3 more
openaire   +2 more sources

Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice

Redox Biology, 2016
Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea.
Ruixia Dong, Dongxu Wang, Xiaoxiao Wang, Ke Zhang, Pingping Chen, Chung S. Yang, Jinsong Zhang   +6 more
doaj   +1 more source

Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

Redox Biology, 2017
Myeloperoxidase produces strong oxidants during the immune response to destroy invading pathogens. However, these oxidants can also cause tissue damage, which contributes to the development of numerous inflammatory diseases. Selenium containing compounds,
Luke Carroll, David I. Pattison, Shanlin Fu, Carl H. Schiesser, Michael J. Davies, Clare L. Hawkins   +5 more
doaj   +1 more source