Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. [PDF]
PLoS ONE, 2008 BackgroundSecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C ...
Karin Anestål +3 more
doaj +1 more source
Mitochondrial Thioredoxin-Glutathione Reductase from Larval Taenia crassiceps (Cysticerci)
Journal of Parasitology Research, 2010 Mitochondrial thioredoxin-glutathione reductase was purified from larval Taenia crassiceps (cysticerci). The preparation showed NADPH-dependent reductase activity with either thioredoxin or GSSG, and was able to perform thiol/disulfide exchange reactions.
Alberto Guevara-Flores +5 more
doaj +1 more source
Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes
BMC Genomics, 2001 Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three recognised forms of mammalian thioredoxin reductase designated as TR1, TR3 and TGR, that ...
Tonissen Kathryn F, Osborne Simone A
doaj +1 more source
Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. [PDF]
PLoS ONE, 2012 Thioredoxin glutathione reductase (TGR) is a member of the mammalian thioredoxin reductase family that has a monothiol glutaredoxin (Grx) domain attached to the thioredoxin reductase module.
Olena Dobrovolska +3 more
doaj +1 more source
Redox Systems in Botrytis cinerea: Impact on Development and Virulence
Molecular Plant-Microbe Interactions, 2014 The thioredoxin system is of great importance for maintenance of cellular redox homeostasis. Here, we show that it has a severe influence on virulence of Botrytis cinerea, demonstrating that redox processes are important for host-pathogen interactions in
Anne Viefhues +3 more
doaj +1 more source
Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia. [PDF]
PLoS ONE, 2013 Histological staining of reactive stroma has been shown to be a predictor of biochemical recurrence in prostate cancer, however, molecular markers of the stromal response to prostate cancer have not yet been fully delineated.
Elizabeth Singer +7 more
doaj +1 more source
Thioredoxin Reductase and its Inhibitors [PDF]
Current Protein & Peptide Science, 2014 Thioredoxin plays a crucial role in a wide number of physiological processes, which span from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics, oxidants and radicals. The redox function of Thioredoxin is critically dependent on the enzyme Thioredoxin NADPH Reductase (TrxR).
SACCOCCIA, FULVIO +6 more
openaire +4 more sources
Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis
Angewandte Chemie, EarlyView.YUCCA enzymes are well known to catalyze the main step of auxin biosynthesis in plants. Here, a hitherto undescribed dual function was discovered, revealing that some YUCCAs also act in chlorophyll degradation. In vitro feedback regulation furthermore suggests a link between chlorophyll degradation and hormone homeostasis and a physiological role of ...
Sina Rütschlin +6 more
wiley +2 more sources
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense. [PDF]
PLoS Pathogens, 2016 Mycobacterium tuberculosis (Mtb) must cope with exogenous oxidative stress imposed by the host. Unlike other antioxidant enzymes, Mtb's thioredoxin reductase TrxB2 has been predicted to be essential not only to fight host defenses but also for in vitro ...
Kan Lin +6 more
doaj +1 more source
Thioredoxin reductase as a pharmacological target
Pharmacological Research, 2021 Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major antioxidant systems that control the redox homeostasis in cells. The thioredoxin system, comprised of TrxR, Trx and NADPH, exerts its activities via a disulfide-dithiol ...
Geir Bjørklund +4 more
openaire +2 more sources