Results 31 to 40 of about 46,151 (247)

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

Nature Communications, 2018
Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout mouse to show how this system reprograms cellular metabolism to enable T cell development ...
Jonathan Muri, Sebastian Heer, Mai Matsushita, Lea Pohlmeier, Luigi Tortola, Tobias Fuhrer, Marcus Conrad, Nicola Zamboni, Jan Kisielow, Manfred Kopf   +9 more
doaj   +1 more source

Cloning of thioredoxin h reductase and characterization of the thioredoxin reductase–thioredoxin h system from wheat [PDF]

Biochemical Journal, 2002
Thioredoxins h are ubiquitous proteins reduced by NADPH— thioredoxin reductase (NTR). They are able to reduce disulphides in target proteins. In monocots, thioredoxins h accumulate at high level in seeds and show a predominant localization in the nucleus of seed cells.
Pérez Ruiz, Juan Manuel, Cejudo Fernández, Francisco Javier, Serrato Recio, Antonio Jesús   +2 more
openaire   +4 more sources

Crystal structure of the human thioredoxin reductase–thioredoxin complex [PDF]

Nature Communications, 2011
Thioredoxin reductase 1 (TrxR1) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox homeostasis, growth, and differentiation. Its importance in various diseases makes TrxR1 a highly interesting drug target. Here we present the first crystal structures of human TrxR1 in complex with its substrate thioredoxin (Trx).
Fritz-Wolf, K., Kehr, S., Stumpf, M., Rahlfs, S., Becker, K.   +4 more
openaire   +3 more sources

Thioredoxin reductase: An emerging pharmacologic target for radiosensitization of cancer

Translational Oncology, 2022
Novel agents are required to increase the radiosensitivity of cancer and improve the outcome of radiotherapy. Thioredoxin (Trx) and thioredoxin reductase (TrxR) reduce the oxidized cysteine thiols in several proteins, which regulate cellular redox ...
Raghavendra S. Patwardhan, Deepak Sharma, Santosh K. Sandur   +2 more
doaj   +1 more source

Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.

PLoS ONE, 2016
Thioredoxin (Trx) is an oxidoreductase with important physiological function. Imbalances in the NADPH/thioredoxin reductase/thioredoxin system are associated with a number of pathologies, particularly cancer, and a number of clinical trials for ...
Clive Metcalfe, Anjana Ramasubramoni, Giordano Pula, Matthew T Harper, Stuart J Mundell, Carmen H Coxon   +5 more
doaj   +1 more source

Oligo-Carrageenan Kappa-Induced Reducing Redox Status and Activation of TRR/TRX System Increase the Level of Indole-3-acetic Acid, Gibberellin A3 and trans-Zeatin in Eucalyptus globulus Trees

Molecules, 2014
Eucalyptus globulus trees treated with oligo-carrageenan (OC) kappa showed an increase in NADPH, ascorbate and glutathione levels and activation of the thioredoxin reductase (TRR)/thioredoxin (TRX) system which enhance photosynthesis, basal metabolism ...
Alberto González, Rodrigo A. Contreras, Gustavo Zúiga, Alejandra Moenne   +3 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The Barley Grain Thioredoxin System – an Update

Frontiers in Plant Science, 2013
Thioredoxin reduces disulfide bonds and play numerous important functions in plants. In cereal seeds, cytosolic h-type thioredoxin facilitates the release of energy reserves during the germination process and is recycled by NADPH-dependent thioredoxin ...
Per eHägglund, Olof eBjörnberg, Nicolas eNavrot, Johanne eMørch Jensen, Kenji eMaeda, Kristine eKirkensgaard, Azar eShahpiri, Abida eSultan, Jakob eBunkenborg, Frank eGubler, José Maria Barrero, Anette eHenriksen, Christine eFinnie, Birte eSvensson   +13 more
doaj   +1 more source

Did a shared thioredoxin-reductase gene mutation lead to maternal peripartum cardiomyopathy and fatal dilated cardiomyopathy in her son? A case report

Case Reports in Women's Health, 2020
Peripartum cardiomyopathy (PPCM) is characterized by development of left ventricular systolic dysfunction and heart failure that occurs towards the end of pregnancy or in the postpartum period in the absence of structural heart disease.
Indranee Rajapreyar, Rachel Sinkey, Salpy V. Pamboukian, Alan Tita   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source