Results 51 to 60 of about 46,151 (247)
Cell Reports, 2014 Botulinum neurotoxins consist of a metalloprotease linked via a conserved interchain disulfide bond to a heavy chain responsible for neurospecific binding and translocation of the enzymatic domain in the nerve terminal cytosol.
Marco Pirazzini +10 more
doaj +1 more source
Structural model of the Plasmodium falciparum Thioredoxin reductase:a novel target for antimalarial drugs [PDF]
Journal of Vector Borne Diseases, 2009 Background: Malaria, a scourge of mankind, imposes a huge socioeconomic burden in tropicalcountries. Emergence of multi-drug resistant malarial parasites impels us to explore novel drugtargets.
Amit Kumar Banerjee +2 more
doaj
Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes
Scientific Reports, 2018 The thioredoxin system plays a predominant role in the control of cellular redox status. Thioredoxin reductase fuels the system with reducing power in the form of NADPH. The TORC1 complex promotes growth and protein synthesis when nutrients, particularly
Cecilia Picazo +2 more
doaj +1 more source
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract This systematic review examines strategies for docosahexaenoic acid (DHA) production by thraustochytrids, focusing on cultivation techniques, fermentation technologies, and carbon/nitrogen optimization to increase productivity. Among 169 eligible articles, the 100 most productive studies (0.7–10.3 g DHA L−1 per day) were analyzed. Quantitative
Jhiovana Cristielly Carrera Silva da Costa +6 more
wiley +1 more source
Methylglyoxal Causes Dysfunction of Thioredoxin and Thioredoxin Reductase in Endothelial Cells
Journal of Pharmacological Sciences, 2009 Methylglyoxal (MG), a reactive dicarbonyl produced during glucose metabolism, induces oxidative stress and apoptosis. Under hyperglycemic conditions, the abnormal accumulation of MG is related to the development of diabetic complications. We examined the
Ryosuke Tatsunami +3 more
doaj +1 more source
Biotechnology Progress, EarlyView.Abstract Red blood cells (RBCs) play a critical role in oxygen and carbon dioxide transport, which is facilitated by RBC‐encapsulated hemoglobin (Hb) and carbonic anhydrase (CA). In addition, RBCs are constantly exposed to oxidative stress due to the intracellular reactive oxygen species (ROS) generated during Hb auto‐oxidation.
Mohd Asim Khan +4 more
wiley +1 more source
Thioredoxin Reductase from Rat Liver [PDF]
European Journal of Biochemistry, 1973 The thioredoxin system was first identified in microorganisms where it participates in redox reactions, such as ribonucleotide reduction, transferring electrons from NADPH to the product formed. It contains two protein components, thioredoxin and thioredoxin reductase. A similar hydrogen transport system has now been demonstrated in rat liver.
openaire +2 more sources
Role of selenium in the pathophysiology of cardiorenal anaemia syndrome
ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai +2 more
wiley +1 more source
Food Bioengineering, EarlyView.ABSTRACT The intake of capsaicin can disrupt the gut microecology and impact health, yet its underlying mechanism is not fully elucidated. This study, by establishing capsaicin‐induced human microbiota‐associated (HMA) mouse models revealed the molecular mechanism by which capsaicin perturbs the gut microbiota and metabolites, leading to intestinal ...
Liangliang Zhu +10 more
wiley +1 more source
PLoS ONE, 2019 The highly extreme conditions of the lower convective layer in the Atlantis II (ATII) Deep brine pool of the Red Sea make it an ideal environment for the search for novel enzymes that can function under extreme conditions.
Elham A Badiea +5 more
doaj +1 more source