Results 161 to 170 of about 169,438 (276)

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, Volume 59, Issue 7, Page 1402-1415, July 2026.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

From the Proteome to Therapeutics: A Multi‐Database Approach to Drug Discovery in Periodontitis—An Exploratory Pilot Study

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.
ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo, Annette Murr, Birte Holtfreter, Sebastian‐Edgar Baumeister, Peter Meisel, Uwe Völker, Werner Weitschies, Henry Völzke, Philipp Kanzow, Elke Hammer, Manuela Gesell Salazar, Thomas Kocher   +11 more
wiley   +1 more source

Flavobacterium oreochromis From Farmed Tambaqui (Colossoma macropomum): Insights Into Genetic, Phenotypic and Pathogenic Diversity

Journal of Fish Diseases, Volume 49, Issue 7, July 2026.
ABSTRACT Flavobacterium spp. are the etiological agents of columnaris disease. Although there is evidence that columnaris poses a significant threat to the farming of tambaqui (Colossoma macropomum), there remains a large gap in understanding the genetic and phenotypic diversities of columnaris‐causing bacteria (CCB).
Elcimara Cardoso Pereira, Mariluce dos Reis Ferreira, Suzana Kotzent, Luiz Fagner Ferreira Nogueira, Guilherme Campos Tavares, Henrique César Pereira Figueiredo, Fabiana Pilarski, Gustavo Moraes Ramos Valladão, Sílvia Umeda Gallani   +8 more
wiley   +1 more source

Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture system. [PDF]

Exp Ther Med, 2021
El Feky SE, Ghany Megahed MA, Abd El Moneim NA, Zaher ER, Khamis SA, Ali LMA.   +5 more
europepmc   +1 more source

Thioredoxin system in colorectal cancer: Its role in carcinogenesis, disease progression, and response to treatment

The thioredoxin system is essential for many physiological processes, including the maintenance of redox signalling pathways. Alterations in the activity, expression and interactions with other signalling pathways can lead to protective or ...
Abdullah, Nurul Akmaryanti, Chua, Jia Xin, Muhamad Zakuan, Noraina, Md Hashim, Nur Fariesha   +3 more
core   +1 more source

Deciphering Cold Stress Resilience: Multiomics Insights in Contrasting Wheat Genotypes From the Western Himalayas

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4577-4598, July 2026.
ABSTRACT Cold stress threatens wheat productivity, particularly in regions with extreme climatic conditions. To elucidate the molecular mechanisms underlying wheat's response to cold stress, we performed a multiomics analysis integrating lipidomics, transcriptomics, proteomics and metabolomics.
Sofora Jan, Farkhandah Jan, Mukesh Rathore, Yogita Singh, Prexha Kapoor, Palak Chaturvedi, Arindam Ghatak, Palakurthi Ramesh, Upendra Kumar, Manoj Prasad, Sundeep Kumar, Sachin Rustgi, Wolfram Weckwerth, Sanjay Kalia, Rajeev Kumar Varshney, Reyazul Rouf Mir   +15 more
wiley   +1 more source

Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells. [PDF]

Molecules, 2021
Zhang W, Zhu Y, Yu H, Liu X, Jiao B, Lu X.   +5 more
europepmc   +1 more source

Genomic and Transcriptomic Analyses Provide Insights Into Erysiphe necator Pathogenicity and Grapevine Response

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4599-4618, July 2026.
ABSTRACT Grapevine powdery mildew, caused by the fungus Erysiphe necator, is one of the most prevalent obligate biotrophic pathogens in vineyards, posing a significant threat to grape production. Despite its impact, research on E. necator pathogenicity and grapevine responses remains limited.
Bo Mu, Ruixin Tang, Zhaolin Teng, Jinfu Chen, Kaicheng Cui, Feng Wei, Wenxiang Kong, Shunyuan Xiao, Xiangnan Xu, Jia‐Yue Feng, Ying‐Qiang Wen   +10 more
wiley   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Adina Borbély, Arnold Steckel, Dávid Papp, Domonkos Pál, Katalin Uray, Viktória Goldschmidt Gőz, Gitta Schlosser   +6 more
wiley   +1 more source