Results 181 to 190 of about 169,438 (276)

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

The Role of Thioredoxin System in Shank3 Mouse Model of Autism. [PDF]

J Mol Neurosci
Bazbaz W, Kartawy M, Hamoudi W, Ojha SK, Khaliulin I, Amal H.   +5 more
europepmc   +1 more source

Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro

Drug Development Research, Volume 87, Issue 4, June 2026.
ABSTRACT Santamarine (SAMA), a Michelia compressa‐derived sesquiterpene lactone, exhibits ROS‑mediated anticancer activity; however, its potential mechanisms and synergy with cisplatin in oral cancer have not been explored. This study investigated SAMA and cisplatin's combined effects and underlying ROS/MAPK mechanisms of action on oral cancer cells ...
Hsin‐I. Lu, Kuan‐Liang Chen, Chung‐Yi Chen, Ching‐Yu Yen, Ammad Ahmad Farooqi, Tsu‐Ming Chien, Jiiang‐Huei Jeng, Bing‐Hung Chen, Hsueh‐Wei Chang   +8 more
wiley   +1 more source

Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications. [PDF]

Antioxidants (Basel)
Seitz R, Tümen D, Kunst C, Heumann P, Schmid S, Kandulski A, Müller M, Gülow K.   +7 more
europepmc   +1 more source

TCM‐Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
This graphical abstract illustrates TCM syndrome differentiation‐guided targeted strategies against NLRP3 inflammasome‐mediated non‐alcoholic fatty liver disease (NAFLD). Metabolic dysfunction and gut‐liver axis dysregulation drive NAFLD progression, activating the NLRP3 inflammasome (comprising NLRP3, ASC, caspase‐1) to trigger cytokine release (IL‐1β,
Yanxia Zhang
wiley   +1 more source

Progress in Research on the Role of the Thioredoxin System in Chemical Nerve Injury. [PDF]

Toxics
Xu X, Zhang L, He Y, Qi C, Li F.
europepmc   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Dysregulation of Non‐Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens

Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.
This study identifies S100A4 as a critical regulator of NMIIA assembly, phosphorylation, and actin cytoskeletal organization in the ocular lens. Loss of S100A4 disrupts lens fiber cell architecture and impairs lens transparency, revealing a previously unrecognized role for S100A4 in maintaining lens homeostasis and structural integrity.
Rupalatha Maddala, Levi K. Lankford, Nikolai P. Skiba, Ponugoti V. Rao   +3 more
wiley   +1 more source

The thioredoxin system in the psychrophilic eubacteriumPseudoalteromonas haloplanktis

, 2007
The thioredoxin system, involved in preservation of the reduced state of cytoplasmic proteins, includes two key components of the intracellular redox balance, namely thioredoxin (Trx) and thioredoxin reductase (TrxR).
P. Falasca, G. Evangelista, RUOCCO, MARIA ROSARIA, M. Masullo, Raimo, Gennaro, G. Salomone, R. Cotugno, G. Raimo, E. De Venditti   +8 more
core  

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host–pathogen interactions, and immune modulation.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
wiley   +1 more source