Results 191 to 200 of about 17,263,040 (272)

Cytoplasmic redox imbalance in the thioredoxin system activates Hsf1 and results in hyperaccumulation of the sequestrase Hsp42 with misfolded proteins. [PDF]

Mol Biol Cell
Goncalves D, Duy DL, Peffer S, Morano KA.   +3 more
europepmc   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity. [PDF]

Nat Commun
Prasad CB, Oo A, Liu Y, Qiu Z, Zhong Y, Li N, Singh D, Xin X, Cho YJ, Li Z, Zhang X, Yan C, Zheng Q, Wang QE, Guo D, Kim B, Zhang J.   +16 more
europepmc   +1 more source

ApoE lipidation state directs immunometabolic reprogramming of human microglia

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION ApoE ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. METHODS Human microglia were treated with lipid‐
Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerem P. Ogbu, Athena A. Schepmoes, Isaac K. Attah, Christy S. Niemeyer, Kayla G. Sprenger, James E. Hassell, Robert H. Eckel, John T. Melchior, Kimberley D. Bruce   +14 more
wiley   +1 more source

Concomitant inhibition of the thioredoxin system and nonhomologous DNA repair potently sensitizes Philadelphia-positive lymphoid leukemia to tyrosine kinase inhibitors. [PDF]

Hemasphere
Komorowski L, Dabkowska A, Madzio J, Pastorczak A, Szczygiel K, Janowska M, Fidyt K, Bielecki M, Hunia J, Bajor M, Stoklosa T, Winiarska M, Patkowska E, Firczuk M.   +13 more
europepmc   +1 more source

Regulation of cyclic electron flow by chloroplast NADPH-dependent thioredoxin system. [PDF]

Plant Direct, 2018
Nikkanen L, Toivola J, Trotta A, Diaz MG, Tikkanen M, Aro EM, Rintamäki E.   +6 more
europepmc   +1 more source

Ketogenic Diet–Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy

Brain and Behavior, Volume 16, Issue 10, October 2026.
Proteomic profiling of the somatosensory cortex revealed that ketogenic diet was associated with remodeling of cortical protein networks in GAERS absence epilepsy, with altered proteins enriched in synaptic and mitochondrial pathways. ABSTRACT Purpose This study investigated the effects of ketogenic diet (KD) intervention on the cortical proteome in ...
Aslihan Gunel, Ulku Guler, Aylin Toplu, Nazli Busra Acikgoz, Bora Onat, Ariorad Moniri, Bekir Salih, Osman Ugur Sezerman, Filiz Onat   +8 more
wiley   +1 more source

On the role of the plant mitochondrial thioredoxin system during abiotic stress. [PDF]

Plant Signal Behav, 2019
Da Fonseca-Pereira P, Daloso DM, Gago J, Nunes-Nesi A, Araújo WL.   +4 more
europepmc   +1 more source

Exploring Vitamin D Metabolism in Gynaecological Malignancies: Redox‐Dependent and Redox‐Independent Anticancer Mechanisms From Preclinical Models to Clinical Evidence

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Gynaecological malignancies account for over 1.4 million new diagnoses, with outcomes constrained by late‐stage presentation and chemoresistance. Dysregulated redox homeostasis is a hallmark of tumourigenesis. Tumour cells maintain elevated basal reactive oxygen species (ROS), which support proliferative signalling but may also increase ...
Hoi Ching Cherry Chan, Sachin Bhoora, Esther Zhou, Sumari Marais, Rivak Punchoo   +4 more
wiley   +1 more source

Interplay Between Epigenetics and Reactive Oxygen Species in Tumor Radioresistance: Mechanisms and Therapeutic Strategies for Radiotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Radiotherapy efficacy is constrained by tumor radioresistance, which arises in part from the interplay between reactive oxygen species (ROS) and epigenetic regulation. This review systematically synthesizes the bidirectional “epigenetics‐ROS interactive network” that governs tumor radiosensitivity. We propose that this network operates through
Zhengmao Yang, Jiaxin Wang, Guofang Wang, Jiamin Zhu, Shengnan Zhang, Wenjian Guo   +5 more
wiley   +1 more source