Results 201 to 210 of about 17,263,040 (272)

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source

Reactive Oxygen Species as Central Coordinators of Organelle Stress and Tumor Radiosensitivity

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Radiotherapy is a major modality for cancer treatment, but therapeutic responses vary substantially across tumor types and patients. Beyond direct DNA damage, radiation‐induced reactive oxygen species (ROS) are increasingly recognized as dynamic regulators of cellular stress responses.
Guangyu Ju, Zimeng Wang, Jingjing Xiao, Qinxue Wu, Zhiying Yang, Yuqing Miao, Shuanghu Yuan, Junchao Qian   +7 more
wiley   +1 more source

The Thioredoxin System is Regulated by the ASK-1/JNK/p38/Survivin Pathway During Germ Cell Apoptosis. [PDF]

Molecules, 2019
Al-Kandari N, Fadel F, Al-Saleh F, Khashab F, Al-Maghrebi M.   +4 more
europepmc   +1 more source

RAF1 Promotes Gstt1‐Mediated Ferroptosis by Promoting KDM1A Recruitment to Facilitate Pilocarpine‐Induced Acute Seizure‐Associated Neuronal Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In the hippocampus of mice with pilocarpine‐induced acute seizures and in glutamate‐treated neuronal cell lines, the mRNA and protein levels of RAF1 were significantly increased. RAF1 interacts with the KDM1A and recruits it to the promoter of Gstt1, thereby inhibiting the transcription of Gstt1.
Tiantian Lu, Yonghong Feng, Xiuling Chen, Liyan Shen, Min Liu, Yanping Jia   +5 more
wiley   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System. [PDF]

Front Microbiol, 2018
May HC, Yu JJ, Guentzel MN, Chambers JP, Cap AP, Arulanandam BP.   +5 more
europepmc   +1 more source

Dietary Selenium and β‐Carotene Contribute to the Inverse Association Between Antioxidant Mixtures and Stroke: Evidence From NHANES Using Mixture Models and Machine Learning

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
In this NHANES study of 37,746 participants, we examined the joint association of six dietary antioxidant‐related nutrients (vitamins A, C, and E, β‐carotene, selenium, and zinc) with stroke, applying 1:1 propensity score matching (matched sub‐cohort, n = 2750), mixture models (WQS, qgcomp, and BKMR), and machine learning with SHAP interpretation ...
Aifang Zhong, Xinmin Deng, Yejun Tan, Rui Lai, Xiaofeng Lv, Xia Zhou, Jiaying Zhu   +6 more
wiley   +1 more source

Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease. [PDF]

Hum Mol Genet, 2018
Mordaunt CE, Shibata NM, Kieffer DA, Czlonkowska A, Litwin T, Weiss KH, Gotthardt DN, Olson K, Wei D, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V.   +13 more
europepmc   +1 more source

Postbiotics Unveiled: The Next Emerging Trend in Functional Foods

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
The graphical abstract shows different postbiotic production techniques, such as sonication, fermentation, heat inactivation, high‐pressure processing, dehydration, pH modification, and omic technologies. Additionally, it highlights the emerging health benefits and applications of postbiotics, including immune modulation, gut–brain axis regulation ...
Zoha Wahid, Abdul Momin Rizwan Ahmad, Farheen Zulfiqar, Syed Hassan Bin Usman Shah, Nilab Mohammadi   +4 more
wiley   +1 more source

Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer. [PDF]

Oncotarget, 2017
Schultz MA, Diaz AM, Smite S, Lay AR, DeCant B, McKinney R, Mascarinas WE, Xia Y, Neumann C, Bentrem D, Dawson DW, Grippo PJ.   +11 more
europepmc   +1 more source