Mapping the phenotypic repertoire of the cytoplasmic 2-Cys peroxiredoxin - Thioredoxin system. 1. Understanding commonalities and differences among cell types. [PDF]
Redox Biol, 2018 Selvaggio G, Coelho PMBM, Salvador A.
europepmc +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4529-4545, June 2026.ABSTRACT Pharmacologic interventions for type 1 diabetes (T1D) have advanced significantly in recent years with the advent of the first FDA approved therapy teplizumab for delaying symptomatic disease onset in 2022. Despite this progress, major hurdles remain in moving toward personalized medicine approaches for T1D.
Jasmine Pipella, Peter J. Thompson
wiley +1 more source
GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR. [PDF]
PLoS One, 2017 Han C +11 more
europepmc +1 more source
The FEBS Journal, Volume 293, Issue 11, Page 3166-3186, June 2026.Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan +4 more
wiley +1 more source
KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery. [PDF]
Sci Rep, 2018 Beyrath J +9 more
europepmc +1 more source
The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione
The FEBS Journal, Volume 293, Issue 12, Page 3683-3705, June 2026.12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper +8 more
wiley +1 more source
Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins
The FEBS Journal, Volume 293, Issue 11, Page 3135-3139, June 2026.Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et al. could advance the engineering of pentatricopeptide repeat proteins, and how in return pentatricopeptide repeat ...
Farley M. Kwok van der Giezen, Ian Small
wiley +1 more source
International Journal of Cosmetic Science, Volume 48, Issue 3, Page 477-488, June 2026.The blend enhanced antioxidation, anti‐glycation, autophagy and circadian regulation in cell and skin models. Key markers included mitochondrial ROS, γ‐H2AX, AGEs, ATP, melatonin, LC3 and SOD. Significant improvements were visualized via fluorescence and quantified with statistical markers.
Lina Wang +4 more
wiley +1 more source
Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system. [PDF]
Antioxid Redox Signal, 2014 Banerjee Mustafi S +6 more
europepmc +1 more source