Results 221 to 230 of about 17,263,040 (272)

Mechanistic characterization of the thioredoxin system in the removal of hydrogen peroxide. [PDF]

Free Radic Biol Med, 2015
Pannala VR, Dash RK.
europepmc   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, Volume 40, Issue 10, Page 6005-6042, October 2026.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Txnip/PDK4‐Mediated Hyperdependence on Fatty‐Acid Oxidation Amplifies Susceptibility of Diabetic Myocardium to Ischemia–Reperfusion Damage

Journal of Diabetes, Volume 18, Issue 10, October 2026.
We show for the first time that the cardiomyocyte subtype (C6 cardiomyocyte) is a cardiomyocyte characterized by myocardial contraction, and the reduction of its number and metabolic heterogeneity is the basis of myocardial ischemia–reperfusion injury in diabetes.
Zheng Zeng, Wei Shi, Yuxuan He, Yue Wang, Cong Pu, Jingtong Tan, Hai Guo, Haiping Ma   +7 more
wiley   +1 more source

Bacterial Contribution to Hydrogen Peroxide Decomposition in Lake Erie Cyanobacterial Harmful Algal Bloom Communities Is Dependent on Bloom Stage

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
A seasonal time series metatranscriptome dataset suggests that neutralising hydrogen peroxide in Microcystis blooms requires a complex division of labour that is further complicated by seasonality and bloom development. ABSTRACT Cyanobacterial harmful algal blooms (cHABs) are expanding globally and often involve toxin‐producing species such as ...
Chelsea E. Donovan, Gabriel Padilla, Madison Ashbaugh, Sophie Bencivenga, Jordan Cibellis, Wilson Ritterpusch, Cameron Tierney, Justin D. Chaffin, Louie L. Wurch, Morgan M. Steffen   +9 more
wiley   +1 more source

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Aging Cell, Volume 25, Issue 10, October 2026.
Our studies for the first time underscore the feasibility of long‐term SIRT6 activation as a pharmacological strategy to maintain the health of the intervertebral disc in the aging spine. ABSTRACT Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain.
Pranay Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah E. Bell, Mallory Toci, Olivia Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud   +11 more
wiley   +1 more source

Pathways of Epithelial Barrier Breakdown and Remodeling in Esophageal Organoids by Commonly Used Surfactants

Allergy, Volume 81, Issue 10, Page 3659-3672, October 2026.
This study shows that SDS and CAPB directly impair esophageal epithelial barrier integrity in primary EoE‐derived models. SDS induces stronger inflammatory, oxidative stress, and keratinization responses than CAPB. Both surfactants promote epithelial remodeling and partial epithelial‐mesenchymal transition (EMT), with CAPB showing a distinct ...
Ozge Ardicli, Duygu Yazici, Huseyn Babayev, Yagiz Pat, Manal Bel Imam, Hang Du, Hassan Melhem, Carina Beha, Laura Buergi, Anja Heider, Juan‐Felipe López, Sena Ardicli, Can Zeyneloğlu, Andrea Kreienbühl, Nino Stocker, Patrick Westermann, Christoph B. Messner, Mübeccel Akdis, Jan Hendrik Niess, Alain Schoepfer, Luc Biedermann, Cezmi A. Akdis, Swiss EoE Cohort Study Group, Patrick Aepli, Luc Biedermann, Ruggero Biral, Carine Blanchard, Lorenzo Botteselle, Simon Buetikofer, Emanuel Burri, Joachim Diebold, Annika Eckhold, Annett Franke, Michèle Frei, Thomas Greuter, Chantal Hasler, Wolfram Jochum, Tanja Kilchmann, Seraina Koller, Andrea Kreienbühl, Fritz Murray, Peter Netzer, Gabrielle Reichhart, Elodie Ristorcelli, Gerhard Rogler, Jean‐Benoit Rossel, Ekaterina Safroneeva, Catherine Saner, Christoph Schlag, Jon‐Duri Senn, Alain Schoepfer, Philipp Schreiner, Christine Sempoux, Dagmar Simon, Hans‐Uwe Simon, Alex Straumann, Sven Trelle, Achim Weber, Niels Willi, Marcel Zwahlen, Willem van de Veen   +60 more
wiley   +1 more source

Insights into the modulation of age‐related macular degeneration: Molecular and systems‐level perspectives

Acta Ophthalmologica, Volume 104, Issue S293, Page S4-S35, October 2026.
ENGLISH SUMMARY In developed countries, age‐related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. Understanding of its pathogenesis is limited and the number of patients is predicted to continue rising. AMD is classified into two main forms: dry and neovascular AMD (dAMD and nAMD, respectively).
Hanna Heloterä
wiley   +1 more source

ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Wan Yu, Yanteng Wang, Na Li, Difei Wang
wiley   +1 more source

Transcriptomic and proteomic signatures underlying nymphal adaptation and foam production in the forage pest Mahanarva spectabilis

Insect Molecular Biology, Volume 35, Issue 5, Page 556-575, October 2026.
RNA‐seq and Batelli gland proteomics of fifth‐instar Mahanarva spectabilis nymphs reveal transcripts and proteins associated with xylem feeding, foam production and environmental interaction. Functional annotation identified genes involved in osmoregulation, detoxification, chemosensation and stress responses, while proteomic analysis confirmed ...
Monique da Silva Bonjour, Angelo José Rinaldi, Eulálio Gutemberg Dias dos Santos, Gabriely Teixeira Bhering Faria, Ana Márcia Escocard de Azevedo Manhães, Jorge Fernando Pereira, Alexander Machado Auad, Maria Goreti de Almeida Oliveira, Humberto Josué de Oliveira Ramos   +8 more
wiley   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source