Results 241 to 250 of about 17,263,040 (272)

Studies toward Novel Peptidomimetic Inhibitors of Thioredoxin–Thioredoxin Reductase System

Journal of Medicinal Chemistry, 2011
Thioredoxins (Trx) are ubiquitous multifunctional low-molecular weight proteins that together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis in NADPH-dependent reactions. An increasing number of data reveal that the Trx-TrxR system is an attractive target for anticancer therapies.
Kłossowski, Szymon, Angelika Muchowicz, Małgorzata Firczuk, Świech, Marta, Redzej, Adam, Jakub Adam Gołąb, Ostaszewski, Ryszard   +6 more
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Characterization of thioredoxin–thioredoxin reductase system in Filifactor alocis

Molecular Oral Microbiology
Abstract Introduction Filifactor alocis is a newly appreciated member of the periodontal community with a strong periodontal disease correlation. Little is known about the survival mechanisms by which F. alocis
Arunima Mishra, Yuetan Dou, Hansel M. Fletcher   +2 more
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[42] Thioredoxin system

1988
Publisher Summary This chapter focuses on the thioredoxin system. Thioredoxin is a small, ubiquitous redox protein with an active center cystine disulfide/dithiol. It may function in several oxidation-reduction reactions and have a regulatory role.
Peter Rowell, Allan J. Darling, William D.P. Stewart   +2 more
openaire   +1 more source

Thioredoxin System in Cell Death Progression

Antioxidants & Redox Signaling, 2012
The thioredoxin (Trx) system, comprising nicotinamide adenine dinucleotide phosphate, Trx reductase (TrxR), and Trx, is critical for maintaining cellular redox balance and antioxidant function, including control of oxidative stress and cell death.Here, we focus on the research progress that is involved in the regulation of apoptosis by Trx systems.
Jun, Lu, Arne, Holmgren
openaire   +2 more sources

The thioredoxin system and cancer therapy: a review

Cancer Chemotherapy and Pharmacology, 2019
Thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH are key members of the Trx system that is involved in redox regulation and antioxidant defense. In recent years, several researchers have provided information about the roles of the Trx system in cancer development and progression.
Fariba Mohammadi, Arash Soltani, Atefeh Ghahremanloo, Hossein Javid, Seyed Isaac Hashemy   +4 more
openaire   +2 more sources

Redox regulation by the human thioredoxin system

BioFactors, 2001
We cloned human thioredoxin as adult T cell leukaemia (ATL)-derived factor (ADF), an inducer of IL-2R/alpha produced by human T cell leukaemia virus type-I (HTLV-I)-transformed cells [18,21]. Thioredoxin (Trx) was originally reported as a hydrogen donor to ribonucleotide reductase, an essential enzyme for DNA sysnthesis in Escherichia coli.
J, Yodoi, H, Masutani, H, Nakamura
openaire   +2 more sources

Linked thioredoxin-glutathione systems in platyhelminths

Trends in Parasitology, 2004
The thioredoxin and glutathione systems play a central role in thiol-disulfide redox homeostasis in many organisms by providing electrons to essential enzymes, and defence against oxidative stress. These systems have recently been characterized in platyhelminth parasites, and the emerging biochemical scenario is the existence of linked processes with ...
Gustavo, Salinas, Murray E, Selkirk, Cora, Chalar, Rick M, Maizels, Cecilia, Fernández   +4 more
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The thioredoxin h system of higher plants

Plant Physiology and Biochemistry, 2004
In plants, thioredoxins h are encoded by a multigenic family of genes (eight in Arabidopsis thaliana, at least five in Populus sp.). The multiplicity of these isoforms raises the question of their specificity. This review focuses on thioredoxins h in two plant models: Arabidopsis and poplar.
Gelhaye, Éric, Rouhier, Nicolas, Jacquot, J.P.   +2 more
openaire   +3 more sources

Thioredoxin reductase in control of the pigmentary system

Clinics in Dermatology, 1989
Abstract Free radical reactions involving molecular oxygen have been implicated in a variety of diseases 1 as well as in the biologic process of aging. 2 The surface of the skin is especially susceptible to free radical damage as a consequence of photochemical reduction reactions between ultraviolet (UV) light and molecular oxygen producing active ...
K U, Schallreuter, J M, Wood
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Thioredoxin System in Premature and Newborn Biology

Antioxidants & Redox Signaling, 2004
Thioredoxin is an important redox protein that is ubiquitously distributed. Thioredoxin exists in dynamic equilibrium between the oxidized and reduced forms, making it an ideal redox-regulatory protein. Thioredoxin, together with thioredoxin reductase and peroxiredoxins, forms a complete redox system that is similar to the glutathione system, but with ...
openaire   +2 more sources