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Selenoproteins and the Thioredoxin System
, 2011 The thioredoxin system, comprising NADPH, flavoprotein thioredoxin reductase (TrxR), and 12 kDa thioredoxin (Trx) with a catalytic dithiol/disulfide, is the ubiquitous biological cellular disulfide reduction system with major functions in DNA synthesis, defense against oxidative stress, and thiol redox control. In mammalian cells Trx system activity is
Jun Lu, Arne Holmgren
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Cellular and Molecular Life Sciences, 2005
Thioredoxins are small proteins catalyzing thiol-disulfide interchange and are involved in the regulation of the redox environment of the cell. In plants, the thioredoxin system is particularly complex since at least 20 thioredoxin isoforms are found in the plant model Arabidopsis thaliana.
Gelhaye, Éric +3 more
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Thioredoxins are small proteins catalyzing thiol-disulfide interchange and are involved in the regulation of the redox environment of the cell. In plants, the thioredoxin system is particularly complex since at least 20 thioredoxin isoforms are found in the plant model Arabidopsis thaliana.
Gelhaye, Éric +3 more
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The thioredoxin system in cancer
Seminars in Cancer Biology, 2006Thioredoxin (Trx), NADPH and thioredoxin reductase (TrxR) comprise a thioredoxin system which exists in nearly all living cells. It functions in thiol-dependent thiol-disulfide exchange reactions crucial to control of the reduced intracellular redox environment, cellular growth, defense against oxidative stress or control of apoptosis and has multi ...
Elias S J, Arnér, Arne, Holmgren
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Thioredoxin in the cardiovascular system
Journal of Molecular Medicine, 2006The thioredoxin (TRX) system (TRX, TRX reductase, and NADPH) is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/oxidation (redox) status. The impairment of cell redox state alters multiple cell pathways, which may contribute to the pathogenesis of cardiovascular disorders including hypertension, atherosclerosis, and heart ...
Cameron J, World +2 more
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Selenoproteins of the thioredoxin system
, 2001 The three isoenzymes of mammalian thioredoxin reductase are dimeric selenoproteins containing an essential catalytically active selenocysteine (See) residue. In contrast to the enzymes from bacteria, yeast and plants, the mammalian enzymes are larger and
Holmgren, A
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The Thioredoxin System — From Science to Clinic
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Stephan, Gromer +2 more
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Studies toward Novel Peptidomimetic Inhibitors of Thioredoxin–Thioredoxin Reductase System
Journal of Medicinal Chemistry, 2011Thioredoxins (Trx) are ubiquitous multifunctional low-molecular weight proteins that together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis in NADPH-dependent reactions. An increasing number of data reveal that the Trx-TrxR system is an attractive target for anticancer therapies.
Szymon, Kłossowski +6 more
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Characterization of thioredoxin–thioredoxin reductase system in Filifactor alocis
Molecular Oral MicrobiologyAbstract Introduction Filifactor alocis is a newly appreciated member of the periodontal community with a strong periodontal disease correlation. Little is known about the survival mechanisms by which F. alocis
Arunima Mishra +2 more
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The thioredoxin h system of higher plants
Plant Physiology and Biochemistry, 2004In plants, thioredoxins h are encoded by a multigenic family of genes (eight in Arabidopsis thaliana, at least five in Populus sp.). The multiplicity of these isoforms raises the question of their specificity. This review focuses on thioredoxins h in two plant models: Arabidopsis and poplar.
Gelhaye, Éric +2 more
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Thioredoxin System in Cell Death Progression
Antioxidants & Redox Signaling, 2012The thioredoxin (Trx) system, comprising nicotinamide adenine dinucleotide phosphate, Trx reductase (TrxR), and Trx, is critical for maintaining cellular redox balance and antioxidant function, including control of oxidative stress and cell death.Here, we focus on the research progress that is involved in the regulation of apoptosis by Trx systems.
Jun, Lu, Arne, Holmgren
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