Results 21 to 30 of about 2,776 (198)

Ligand Screening and Discovery Using Cocktail Soaking and Automated Microcrystal Electron Diffraction. [PDF]

ChemMedChem
Cocktail soaking using single‐crystal X‐ray diffraction allows high‐throughput crystallographic ligand screening against protein targets. However, protein microcrystals are not amenable to this approach. Herein, a workflow integrating cocktail soaking with automated microcrystal electron diffraction to allow rapid ligand screening, structure ...
Lin J, Gallenito MJ, Hattne J, Gonen T.
europepmc   +2 more sources

Design, synthesis, and evaluation of novel racecadotril-tetrazole-amino acid derivatives as new potent analgesic agents

Research in Pharmaceutical Sciences, 2021
Background and purpose: Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse.
Mehdi Asadi, Maryam Mohammadi-Khanaposhtani, Faezeh Sadat Hosseini, Mahdi Gholami, Ahmad Reza Dehpour, Massoud Amanlou   +5 more
doaj   +1 more source

Granulocyte-colony stimulating factor attenuates oligomeric amyloid β neurotoxicity by activation of neprilysin. [PDF]

PLoS ONE, 2014
Soluble oligomeric amyloid β (oAβ) causes synaptic dysfunction and neuronal cell death, which are involved in the pathogenesis of Alzheimer's disease (AD).
Yukiko Doi, Hideyuki Takeuchi, Hiroyuki Mizoguchi, Kazuya Fukumoto, Hiroshi Horiuchi, Shijie Jin, Jun Kawanokuchi, Bijay Parajuli, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumura   +10 more
doaj   +1 more source

Concomitant medication in patients with bradykinin‐mediated angioedema – there's more than ACE inhibitors

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 21, Issue 11, Page 1283-1289, November 2023., 2023
Summary Bradykinin‐mediated angioedema is a rare, non‐allergic, potentially life‐threatening disease. ACE inhibitor‐induced angioedema and hereditary angioedema (HAE) are the two most common presentations. Therapeutic options, pathophysiology and diagnosis continue to be investigated, with considerable progress in HAE over the last few decades. For all
Robin Lochbaum, Thomas K. Hoffmann, Jens Greve, Janina Hahn   +3 more
wiley   +1 more source

Medikamente als Auslöser Bradykinin‐vermittelter Angioödeme – mehr als ACE‐Hemmer

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 21, Issue 11, Page 1283-1290, November 2023., 2023
Zusammenfassung Bradykinin‐vermittelte Angioödeme sind seltene, nichtallergische und potenziell lebensbedrohliche Krankheiten. Die beiden bekanntesten Formen sind das ACE‐Hemmer‐induzierte Angioödem und das hereditäre Angioödem (HAE). Die therapeutischen Möglichkeiten, die Pathophysiologie und die Diagnostik werden weiter erforscht, wobei beim HAE in ...
Robin Lochbaum, Thomas K. Hoffmann, Jens Greve, Janina Hahn   +3 more
wiley   +1 more source

The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders

British Journal of Pharmacology, Volume 180, Issue 7, Page 879-893, April 2023., 2023
Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in the protection of endogenous opioid peptides to activate opioid receptors, avoiding the classical opioid‐like side effects.
Beltran Alvarez‐Perez, Hervé Poras, Rafael Maldonado   +2 more
wiley   +1 more source

Properties and modulation of excitatory inputs to the locus coeruleus

The Journal of Physiology, Volume 600, Issue 22, Page 4897-4916, 15 November 2022., 2022
Abstract figure legend Noradrenaline (NA) neurons in the locus coerueleus (LC) receive glutamatergic inputs from various regions of the brain that drive their activity. In order to characterize how these afferents differ from one another with respect to synaptic properties, an optogenetic approach was used to isolate inputs from three specific regions:
Kelsey Barcomb, Samantha S. Olah, Matthew J. Kennedy, Christopher P. Ford   +3 more
wiley   +1 more source

Development and validation of an immune‐related prognosis signature associated with hypoxia and ferroptosis in hepatocellular carcinoma

Cancer Medicine, Volume 11, Issue 11, Page 2329-2341, June 2022., 2022
A five‐gene prognostic signature associated with hypoxia and ferroptosis was identified and verified based on bioinformatics methods. Furthermore, this risk score system could stratify the immune status of patients and provide new guidance for exploring the potential mechanism of hepatocellular carcinoma development and precise treatment.
Chun‐Bo Yang, Han‐Xin Feng, Chao‐Liu Dai   +2 more
wiley   +1 more source

CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis. [PDF]

PLoS ONE, 2016
CD10 has been widely used in cancer diagnosis. We previously demonstrated that its expression in melanoma increased with tumor progression and predicted poor patient survival.
Junna Oba, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Min Liu, Takeru Abe, Akihito Hagihara, Takehiko Yokomizo, Masutaka Furue   +7 more
doaj   +1 more source

Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration

Aging Cell, Volume 21, Issue 5, May 2022., 2022
Proteases are a large family of proteolytic enzymes located in all cell compartments and in the extracellular space. Proteases impact all hallmarks of cellular and tissue aging, and the onset and progression of age‐related diseases including neurodegeneration.
Mamta Rai, Michelle Curley, Zane Coleman, Fabio Demontis   +3 more
wiley   +1 more source