Results 31 to 40 of about 2,776 (198)
ChemMedChem, Volume 16, Issue 22, Page 3410-3417, November 19, 2021., 2021 Thiols are potent inhibitors of metallo‐β‐lactamases, major resistance factors in Gram‐negative bacteria. Rh(II)‐based coupling procedure of dithiols to diazo building blocks was adopted for diversity‐oriented synthesis of a library of metallo‐β‐lactamase inhibitors.
Mikhail Krasavin +13 more
wiley +1 more source
Advanced Science, Volume 8, Issue 19, October 6, 2021., 2021 CD10, a transmembrane hydrolase expressed by a subset of carcinoma‐associated fibroblasts, drives tumor progression by degrading an anti‐tumoral peptide, osteogenic growth peptide (OGP). OGP impairs tumor lipid desaturation and consequently suppresses cancer stem cells (CSCs). This study sheds new light on a nexus between the niche and lipid metabolism
Shubin Yu +18 more
wiley +1 more source
Physiological Reports, Volume 9, Issue 6, March 2021., 2021 RAS blockade by a renin inhibitor (aliskiren) or neprilysin inhibition by sacubitril separately led to significant attenuation in the renal IRI‐induced renal dysfunction. The combination of aliskiren and sacubitril was more effective than either one alone. Abstract The natriuretic peptide (NP) system counter‐regulates the renin‐angiotensin system (RAS),
Fayez T. Hammad +6 more
wiley +1 more source
From ARB to ARNI in Cardiovascular Control [PDF]
, 2016 Coexistence of hypertension, diabetes mellitus and chronic kidney disease synergistically aggravates the risk of cardiovascular and renal morbidity and mortality.
Danser, A.H.J. (Jan) +3 more
core +1 more source
Disease Markers, Volume 2021, Issue 1, 2021., 2021 Objective. Dysregulation of cell cycle progression (CCP) is one of the hallmarks of cancer. Here, our study is aimed at developing a CCP‐derived gene signature for predicting high‐risk population of hepatocellular carcinoma (HCC). Methods. Our study retrospectively analyzed the transcriptome profiling and clinical information of HCC patients from The ...
Yongfeng Hui +7 more
wiley +1 more source
Impact of clinically tested NEP/ACE inhibitors on tumor uptake of [111In-DOTA]MG11 [PDF]
, 2016 Background: We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides.
Jong, M. (Marion) de +6 more
core +5 more sources
Beneficial effects of combined AT1 receptor/neprilysin inhibition (ARNI) versus AT1 receptor blockade alone in the diabetic eye [PDF]
, 2016 PURPOSE. Dysfunction of the renin-angiotensin system (RAS) contributes to pathogenesis of diabetic retinopathy (DR). Yet RAS blockers have only limited beneficial effects on progression of DR in clinical trials. The natriuretic peptide system offsets RAS,
Batenburg, W.W. (Wendy) +8 more
core +5 more sources
Sex differences in the aging pattern of renin–angiotensin system serum peptidases [PDF]
, 2017 BACKGROUND: Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin–angiotensin system ...
A. B. Fraile-Bermúdez +7 more
core +6 more sources
Opioid Facilitation of β-Adrenergic Blockade: A New Pharmacological Condition?
Pharmaceuticals, 2015 Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect ...
Joseph Vamecq +3 more
doaj +1 more source
Why dried blood spots are an ideal tool for CYP1A2 phenotyping [PDF]
, 2014 Background and Objective: Dried blood spot (DBS) sampling has gained wide interest in bioanalysis during the last decade and has already been successfully applied in pharmacokinetic and phenotyping studies.
De Kesel, Pieter +2 more
core +2 more sources