Results 31 to 40 of about 2,711 (217)

Medikamente als Auslöser Bradykinin‐vermittelter Angioödeme – mehr als ACE‐Hemmer

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 21, Issue 11, Page 1283-1290, November 2023., 2023
Zusammenfassung Bradykinin‐vermittelte Angioödeme sind seltene, nichtallergische und potenziell lebensbedrohliche Krankheiten. Die beiden bekanntesten Formen sind das ACE‐Hemmer‐induzierte Angioödem und das hereditäre Angioödem (HAE). Die therapeutischen Möglichkeiten, die Pathophysiologie und die Diagnostik werden weiter erforscht, wobei beim HAE in ...
Robin Lochbaum, Thomas K. Hoffmann, Jens Greve, Janina Hahn   +3 more
wiley   +1 more source

The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: A novel possible therapeutic approach for opioid use disorders

British Journal of Pharmacology, Volume 180, Issue 7, Page 879-893, April 2023., 2023
Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in the protection of endogenous opioid peptides to activate opioid receptors, avoiding the classical opioid‐like side effects.
Beltran Alvarez‐Perez, Hervé Poras, Rafael Maldonado   +2 more
wiley   +1 more source

Properties and modulation of excitatory inputs to the locus coeruleus

The Journal of Physiology, Volume 600, Issue 22, Page 4897-4916, 15 November 2022., 2022
Abstract figure legend Noradrenaline (NA) neurons in the locus coerueleus (LC) receive glutamatergic inputs from various regions of the brain that drive their activity. In order to characterize how these afferents differ from one another with respect to synaptic properties, an optogenetic approach was used to isolate inputs from three specific regions:
Kelsey Barcomb, Samantha S. Olah, Matthew J. Kennedy, Christopher P. Ford   +3 more
wiley   +1 more source

Effects of microinjection of peptidase inhibitors, bestatin and thiorphan, into the vasopressinergic nuclei on the urine outflow

Japanese Journal of Pharmacology, 1990
Hiromi Tsushima, Mayumi Mori, Tomohiro Matsuda   +2 more
openalex   +3 more sources

Development and validation of an immune‐related prognosis signature associated with hypoxia and ferroptosis in hepatocellular carcinoma

Cancer Medicine, Volume 11, Issue 11, Page 2329-2341, June 2022., 2022
A five‐gene prognostic signature associated with hypoxia and ferroptosis was identified and verified based on bioinformatics methods. Furthermore, this risk score system could stratify the immune status of patients and provide new guidance for exploring the potential mechanism of hepatocellular carcinoma development and precise treatment.
Chun‐Bo Yang, Han‐Xin Feng, Chao‐Liu Dai   +2 more
wiley   +1 more source

Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration

Aging Cell, Volume 21, Issue 5, May 2022., 2022
Proteases are a large family of proteolytic enzymes located in all cell compartments and in the extracellular space. Proteases impact all hallmarks of cellular and tissue aging, and the onset and progression of age‐related diseases including neurodegeneration.
Mamta Rai, Michelle Curley, Zane Coleman, Fabio Demontis   +3 more
wiley   +1 more source

RhII‐Catalyzed De‐symmetrization of Ethane‐1,2‐dithiol and Propane‐1,3‐dithiol Yields Metallo‐β‐lactamase Inhibitors

ChemMedChem, Volume 16, Issue 22, Page 3410-3417, November 19, 2021., 2021
Thiols are potent inhibitors of metallo‐β‐lactamases, major resistance factors in Gram‐negative bacteria. Rh(II)‐based coupling procedure of dithiols to diazo building blocks was adopted for diversity‐oriented synthesis of a library of metallo‐β‐lactamase inhibitors.
Mikhail Krasavin, Daniil Zhukovsky, Igor Solovyev, Darina Barkhatova, Dmitry Dar'in, Denia Frank, Giada Martinelli, Lilia Weizel, Anna Proschak, Marco Rotter, Jan S. Kramer, Steffen Brunst, Thomas A. Wichelhaus, Ewgenij Proschak   +13 more
wiley   +1 more source

CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis. [PDF]

PLoS ONE, 2016
CD10 has been widely used in cancer diagnosis. We previously demonstrated that its expression in melanoma increased with tumor progression and predicted poor patient survival.
Junna Oba, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Min Liu, Takeru Abe, Akihito Hagihara, Takehiko Yokomizo, Masutaka Furue   +7 more
doaj   +1 more source

A CD10‐OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1

Advanced Science, Volume 8, Issue 19, October 6, 2021., 2021
CD10, a transmembrane hydrolase expressed by a subset of carcinoma‐associated fibroblasts, drives tumor progression by degrading an anti‐tumoral peptide, osteogenic growth peptide (OGP). OGP impairs tumor lipid desaturation and consequently suppresses cancer stem cells (CSCs). This study sheds new light on a nexus between the niche and lipid metabolism
Shubin Yu, Yiwen Lu, An Su, Jianing Chen, Jiang Li, Boxuan Zhou, Xinwei Liu, Qidong Xia, Yihong Li, Jiaqian Li, Min Huang, Yingying Ye, Qiyi Zhao, Sushi Jiang, Xiaoqing Yan, Xiaojuan Wang, Can Di, Jiayao Pan, Shicheng Su   +18 more
wiley   +1 more source

The effect of neprilysin and renin inhibition on the renal dysfunction following ischemia‐reperfusion injury in the rat

Physiological Reports, Volume 9, Issue 6, March 2021., 2021
RAS blockade by a renin inhibitor (aliskiren) or neprilysin inhibition by sacubitril separately led to significant attenuation in the renal IRI‐induced renal dysfunction. The combination of aliskiren and sacubitril was more effective than either one alone. Abstract The natriuretic peptide (NP) system counter‐regulates the renin‐angiotensin system (RAS),
Fayez T. Hammad, Suhail Al‐Salam, Sarah S. AlZaabi, Maryam M. Alfalasi, Awwab F. Hammad, Javed Yasin, Loay Lubbad   +6 more
wiley   +1 more source