Results 31 to 40 of about 2,737 (218)
AFM-IN-SEM analyses of thiorphan assembly on ZnO polar and nonpolar surfaces [PDF]
NANOCON Conference Proeedings, 2023 E. Ukraintsev +3 more
semanticscholar +2 more sources
Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats [PDF]
British Journal of Pharmacology, 2003 Cirrhosis is associated with cardiovascular and renal dysfunction including sodium retention. Many vasoactive peptides such as atrial natriuretic peptide (ANP) and endothelin‐1 (ET‐1) are degraded by neutral endopeptidase 24.11 (NEP). We investigated the hemodynamic and renal effects of thiorphan, a NEP inhibitor, in a rat cirrhosis model.
K S Park +6 more
openalex +4 more sources
Japanese Journal of Pharmacology, 1984 The role of each enkephalin-hydrolyzing peptidase in the inhibitory potency of exogenously added enkephalins in the myenteric plexus-longitudinal muscle preparation of guinea-pig ileum was studied by using the relatively specific inhibitor of each enzyme.
K. Aoki, M. Kajiwara, T. Oka
semanticscholar +2 more sources
Japanese Journal of Pharmacology, 1986 The enkephalin-hydrolyzing peptidases in mouse vas deferens were studied and compared with those in guinea pig ileum which had been characterized in the previous study.
K. Aoki, M. Kajiwara, T. Oka
semanticscholar +2 more sources
Effects of neutral endopeptidase (neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: studies with thiorphan and omapatrilat. [PDF]
Cardiovascular Therapeutics, 2014 J. Dalzell +9 more
semanticscholar +2 more sources
Relationship between enkephalinase inhibition of thiorphan in vivo and its analgesic activity.
Journal of Pharmacobio-Dynamics, 1985 The relationship between enkephalinase inhibition by thiorphan in vivo and analgesic activity in nociceptive tests was studied. The analgesic activity of thiorphan in various nociceptive tests was compared with that of a narcotic analgesic, morphine and antipyretic analgesic, antipyrine.
Mitsugu Hachisu +4 more
openalex +4 more sources
Ligand Screening and Discovery Using Cocktail Soaking and Automated Microcrystal Electron Diffraction. [PDF]
ChemMedChemCocktail soaking using single‐crystal X‐ray diffraction allows high‐throughput crystallographic ligand screening against protein targets. However, protein microcrystals are not amenable to this approach. Herein, a workflow integrating cocktail soaking with automated microcrystal electron diffraction to allow rapid ligand screening, structure ...
Lin J, Gallenito MJ, Hattne J, Gonen T.
europepmc +2 more sources
Research in Pharmaceutical Sciences, 2021 Background and purpose: Although pain is one of the most common symptoms of diseases, it is often mismanaged due to limited access to painkillers and ineffectiveness, unacceptable side effects, or the possibility of abuse.
Mehdi Asadi +5 more
doaj +1 more source
Granulocyte-colony stimulating factor attenuates oligomeric amyloid β neurotoxicity by activation of neprilysin. [PDF]
PLoS ONE, 2014 Soluble oligomeric amyloid β (oAβ) causes synaptic dysfunction and neuronal cell death, which are involved in the pathogenesis of Alzheimer's disease (AD).
Yukiko Doi +10 more
doaj +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 21, Issue 11, Page 1283-1289, November 2023., 2023 Summary Bradykinin‐mediated angioedema is a rare, non‐allergic, potentially life‐threatening disease. ACE inhibitor‐induced angioedema and hereditary angioedema (HAE) are the two most common presentations. Therapeutic options, pathophysiology and diagnosis continue to be investigated, with considerable progress in HAE over the last few decades. For all
Robin Lochbaum +3 more
wiley +1 more source