Results 91 to 100 of about 14,165 (252)

Advances in Xanthine Oxidase Inhibition: A Review of Potential Bioactive Synthetic Compounds

Archiv der Pharmazie, Volume 358, Issue 8, August 2025.
This review article looks at new synthetic xanthine oxidase inhibitors discovered in the last 5 years (2025–2020). It covers an analysis of the advances, structural diversity, biological potential of the molecules investigated and future prospects in drug development.
Giorgio Antoniolli, Gabriel Rodrigues de Moraes, Rafael Porreca Neves da Costa, Giovani Augusto Rosendo de Campos, Fernando Coelho   +4 more
wiley   +1 more source

In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors

Pharmaceuticals
Background/Objectives: Four years after the COVID-19 pandemic, a very limited number of drugs has been marketed; thus, the search for new medications still represents a compelling need.
Michele Tonelli, Anna Sparatore, Ivan Bassanini, Valeria Francesconi, Fabio Sparatore, Kevin K. Maina, Serena Delbue, Sarah D’Alessandro, Silvia Parapini, Nicoletta Basilico   +9 more
doaj   +1 more source

Novel bis(thiosemicarbazones) of the 3,5-diacetyl-1,2,4-triazol series and their platinum(ii) complexes: chemistry, antiproliferative activity and preliminary nephrotoxicity studies [PDF]

, 2011
Dalton Transactions 40.21 (2011): 5738-5745. Reproduced by permission of The Royal Society of ChemistryThe preparation and characterization of three novel 4N- monosubstituted bis(thiosemicarbazone) ligands of 3,5-diacetyl-1,2,4-triazol series and their ...
Hernández, Carolina, Matesanz, Ana I., Rodríguez, Ana, Souza, Pilar   +3 more
core   +2 more sources

SYNTHESIS, ANTIOXIDANT ACTIVITY AND ADME ANALYSIS OF SOME N4-SUBSTITUTED THIOSEMICARBAZONES WITH β–IONONE FRAGMENT

Studia Universitatis Moldaviae: Stiinte reale si ale naturii
Thiosemicarbazones are organic compounds with remarkable biological properties, including anticancer, antibiotic, antifungal, and antioxidant effects.
USM ADMIN
doaj  

Synthesis, antibacterial activity and DNA interactions of lanthanide(III) complexes of N(4)-substituted thiosemicarbazones

Universitas Scientiarum, 2018
This paper reports the synthesis and detailed characterization of six novel lanthanide complexes of La(III), Eu(III) and Nd(III) with N(4)-substituted thiosemicarbazones derived from the 2-carboxybenzaldehyde.
Juan-David Londoño-Mosquera, Alberto Aragón-Muriel, Dorian Polo Cerón   +2 more
doaj   +1 more source

Biologically active thiosemicarbazone Fe chelators and their reactions with ferrioxamine B and ferric EDTA; a kinetic study [PDF]

, 2012
The Fe abstraction from Fe /DFO and Fe /EDTA complex systems by thiosemicarbazone ligands derived from 2-acetylpyridine has been studied from a kinetico-mechanistic perspective at relevant pH conditions and at varying temperatures and buffer solutions ...
Bernhardt, Paul V., Martínez, Manuel, Rodríguez, Carlos, Vazquez, Marta   +3 more
core   +1 more source

Copper(II) Complexes with Highly Water-Soluble L- and D-Proline Thiosemicarbazone Conjugates as Potential Inhibitors of Topoisomerase IIα [PDF]

, 2013
Two proline-thiosemicarbazone bioconjugates with excellent aqueous solubility, namely 3-methyl-(S)-pyrrolidine-2-carboxylate-2-formylpyridine thiosemicarbazone (L-Pro-FTSC or (S)-H2L) and 3-methyl-(R)-pyrrolidine-2-carboxylate-2-formylpyridine ...
Arion Vladimir B., Bacher Felix, Bognár Gabriella M., Enyedy Éva Anna, Kiss Tamás, Klapproth Erik, Nagy Nóra Veronika, Novak Maria S., Rockenbauer Antal, Trondl Robert   +9 more
core   +1 more source

Crystal structure of (2E)-N-methyl-2-(2-oxo-1,2-dihydroacenaphthylen-1-ylidene)hydrazinecarbothioamide

Acta Crystallographica Section E, 2014
In the title compound, C14H11N3OS, the acenaphthylene ring system and hydrazinecarbothioamide unit (=N—NH—C=S—NH–) are essentially coplanar [with maximum deviations from their mean planes of −0.009 (2) and 0.033 (2) Å, respectively], and make a dihedral ...
G. Vimala, J. Govindaraj, J. Haribabu, R. Karvembu, A. SubbiahPandi   +4 more
doaj   +1 more source

Synthesis, crystal structures and antimicrobial activities of 3-methyl and 3-bromo substituted benzo[b]thiophene based thiosemicarbazones

, 2023
E. Öztürk, Elif Subaşı, E.S. Çakmakçı, Aslı Şahiner, Betül Şen   +4 more
openalex   +1 more source

New Complexes of Nickel (II) with Mixed Ligands(2-oxime-4-(hydroxl benzilidine)pentane and (Thiosemicarbazones) and (Glycine) or(Metformine),Evaluation of Biological Activites and laser Irradiation [PDF]

, 2020
Ahlam Al-Bayati, Zuhoor Al-Taai
openalex   +1 more source