Results 81 to 90 of about 14,165 (252)

New bioactive 2,6-diacetylpyridine bis(p-chlorophenylthiosemicarbazone) ligand and its Pd(II) and Pt(II) complexes: Synthesis, characterization, cytotoxic activity and DNA binding ability [PDF]

, 2014
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Inorganic Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Hernández, Carolina, Matesanz, Ana I., Souza, Pilar   +2 more
core   +2 more sources

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors

ChemistryOpen, Volume 14, Issue 11, November 2025.
Novel benzimidazothiazole–thiazole hybrids are synthesized and evaluated for anticancer activity against HCT‐116 colon cancer cells. Compound 16b shows superior cytotoxicity over doxorubicin. Molecular docking confirms strong binding to 6MTU protein, and ADMET profiling indicates favorable pharmacokinetics and low toxicity.
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
wiley   +1 more source

Preparación y caracterización de compuestos de inclusión entre Rh(III), Ni(II), 2-acetil piridina tiosemicarbazonas y β-ciclodextrina [PDF]

, 2015
En este trabajo se describe la preparación y caracterización de los compuestos de inclusión entre el ligante 2-acetilpiridina tiosemicarbazona (HAPTSC) y los complejos cloruro de bis(2-acetilpiridina tiosemicarbazona)rodio(III), [Rh(HAPTSC)2]Cl3, y ...
Burgos Castellanos, Ana Esperanza, Daza Agudelo, Jorge Ivan, de Brito Brandao, Pedro Filipe   +2 more
core   +1 more source

Unveiling Benzoxazole‐Substituted Thiazolyl‐Pyrazole Derivatives Inducing Apoptosis by Targeting β‐Tubulin and Caspase‐3

ChemMedChem, Volume 20, Issue 17, September 11, 2025.
BP(1‐6) compounds designed from Benzoxazole and Thiazolyl‐Pyrazole scaffolds exhibited potent antitubulin and caspase‐3 activity in MDA‐MB‐231 cells. BP‐6 notably triggered apoptosis and disrupted cell proliferation. Docking studies validated strong binding affinities of BP‐2 and BP‐6 toward β‐tubulin and caspase‐3, suggesting promising therapeutic ...
Burak Kuzu, Mustafa Cakir, Eda Acikgoz, Mehmet Abdullah Alagoz   +3 more
wiley   +1 more source

Photocatalytic Hydrogen Production Enhanced by Copper(I) Pyridinium–Selenolate Complexes Supported on Mesoporous Titania

European Journal of Inorganic Chemistry, Volume 28, Issue 25, September 11, 2025.
Non‐noble metal complexes are employed as co‐catalysts of m‐TiO2 to improve the photocatalytic production of green hydrogen from water photolysis. Six new copper(I) pyridinium–selenolate complexes have been fully characterized and utilized for the development of photocatalysts intended for heterogeneous photocatalysis.
Leonardo Carneiro Lanes, Rodrigo Cervo, Robert Alan Burrow, Bernardo Almeida Iglesias, Natália de Freitas Daudt, Ernesto Schulz Lang, Bárbara Tirloni, Roberta Cargnelutti   +7 more
wiley   +1 more source

Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond

MedComm, Volume 6, Issue 9, September 2025.
The potential of natural compounds to modulate the Hippo/YAP signaling pathway, a critical regulator of cell proliferation, differentiation, and survival, is explored. Dysregulation of this pathway is associated with various cancers, making it a target for therapeutic intervention.
Rajni Bala, Reecha Madaan, Onkar Bedi, Amrinder Singh, Ayushi Taneja, Renu Dwivedi, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Laura Itzel Quintas‐Granados, Hernán Cortés, Dietrich Büsselberg, Gerardo Leyva‐Gómez, Javad Sharifi‐Rad, William C. Cho   +13 more
wiley   +1 more source

A Bis‐Thiosemicarbazone Pd(II) SiO2 Nanoparticle Conjugate for CC Coupling Catalysis

European Journal of Inorganic Chemistry, Volume 28, Issue 23, August 26, 2025.
The thiosemicarbazone (TSC) Pd complex–SiO2 nanoparticle conjugate [PdL]–APTES–SiO2 (APTES = (3‐aminopropyl)triethoxysilane) was synthesized through covalent binding of the pentadentate bis(N4‐(2‐ethylphenyl)) 2,6‐diacetyl‐pyridine TSC onto monodispersed SiO2, followed by coordination of Pd(II) and used as precatalysts in Suzuki–Miyaura‐type cross ...
Eric Tobechukwu Anthony, Selina Olthof, Stefan Roitsch, Klaus Meerholz, Sanjay Mathur, Axel Klein   +5 more
wiley   +1 more source

Investigation of potential anti-radiation and anti-neoplastic compounds related to plant growth regulators second quarterly progress report, 1 oct. 1964 - 1 jan. 1965 [PDF]

Antiradiation and antineoplastic compounds related to plant growth regulators - cytotoxic effects and radiation ...
Norman, D., Schultz, R. D.
core   +1 more source

Synthesis, DFT Studies, and Molecular Docking Analysis of a Novel Acylpyrazolone Schiff Base and Its Metal(II) Complexes

Applied Organometallic Chemistry, Volume 39, Issue 8, August 2025.
Acylpyrazolone Schiff of antipyrine and its metal complexes were synthesized. The ligand was crystallized in monoclinic crystal system with space group P21/c while the metal complexes formed showed more stability for pseudo‐tetrahedral complexes than the octahedral forms as confirmed by DFT calculations. ABSTRACT Novel Schiff base ligand 1,5‐dimethyl‐4‐
Nkechinyere N. Ukwueze, Jeanet Conradie, Marrigje M. Conradie, Cosmas C. Eze, Uchechukwu S. Oruma, Sunday N. Okafor, Pius O. Ukoha, Nnamdi L. Obasi, Necmi Dege, Oguejiofo T. Ujam, Chigozie J. Ezeorah   +10 more
wiley   +1 more source

New resource-efficient and green synthesis methods for biologically active derivatives of urea [PDF]

, 2017
Developed were highly effective solvent-free processes for preparation of substituted ureas containingpharmacophore substituents (benzhydryl ureas, dihydroquinazolinones, semicarbazones, thiosemicarbazonesand guanylhydrazones), consistent with green ...
Filimonov, Viktor Dmitrievich, Kuksenok, Vera Yurievna, Shtrykova, Viktoriya Viktorovna, Sidel’nikova, S. P.   +3 more
core   +2 more sources