Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284. [PDF]
FEBS LettTuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Di Napoli G +10 more
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Expression, purification, crystallization and preliminary X-ray analysis of Rv3117, a probable thiosulfate sulfurtransferase (CysA3) from Mycobacterium tuberculosis. [PDF]
Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Witholt SJ +5 more
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Thiosulfate sulfurtransferase and UDP-glucuronosyltransferase activities in cholestatic rat liver induced by common bile duct ligation [PDF]
Experimental & Molecular Medicine, 1997 We have investigated the effect of cholestasis on the hepatic thiosulfate sulfurtransferase (rhodanese) and UDP-glucuronosyltransferase (UDP-GT) activities in rats. Rhodanese activities in the liver cytosol, mitochondria and microsomal fractions as well as in the rat serum, and UDP-GT activity in the microsome have been investigated for a period of 42 ...
Jong-Sool Ihm, You-Hee Kim
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Studies of functionally important structural flexibility of thiosulfate sulfurtransferase
Biophysical Journal, 1980 The enzyme thiosulfate sulfurtransferase (TST; rhodanese; EC 2.8.1.1) catalyzes the transfer of the outer sulfur of thiosulfate (S/sub 2/O/sub 3//sup - -/) to a variety of nucleophilic acceptors such as cyanide (CN/sup -/). During the course of this reaction the enzyme cycles through two stable isolatable catalytic intermediates: the free enzyme, (E ...
Paul M. Horowitz
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Thiosulfate Sulfurtransferase and Its Impact on Mitochodnrial Health [PDF]
With the rapid development of the global economy and technology, metabolic disorders have become increasingly prevalent due to environmental, lifestyle, and genetic factors. Among various biological processes, mitochondrial dysfunction has been identified as a key contributor to numerous diseases, underscoring the essential role of mitochondria in ...
Yang Luo
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Sulfurtransferases and Cystathionine Beta-Synthase Expression in Different Human Leukemia Cell Lines
Biomolecules, 2022 The studies concerned the expression of sulfurtransferases and cystathionine beta-synthase in six human leukemia cell lines: B cell acute lymphoblastic leukemia-B-ALL (REH cells), T cell acute lymphoblastic leukemia-T-ALL (DND-41 and MOLT-4 cells), acute
Halina Jurkowska +3 more
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Structural and biochemical characterization of an encapsulin-associated rhodanese from Acinetobacter baumannii. [PDF]
Protein SciAbstract Rhodanese‐like domains (RLDs) represent a widespread protein family canonically involved in sulfur transfer reactions between diverse donor and acceptor molecules. RLDs mediate these transsulfuration reactions via a transient persulfide intermediate, created by modifying a conserved cysteine residue in their active sites.
Benisch R, Giessen TW.
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Antioxidants, 2022 Hydrogen sulfide (H2S) is a toxic gas that has important regulatory functions. In the colon, H2S can be produced and detoxified endogenously. Both too little and too much H2S exposure are associated with inflammatory bowel disease (IBD), a chronic ...
Nathalie Stummer +10 more
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Sulfane sulfur deficiency in malignant cells, increasing the inhibiting action of acetone cyanohydrin in tumor growth [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To demonstrate the irreversible poisoning action of the acetone cyanohydrin (AC) in malignant cells. METHODS: Thirty male Swiss mice were inoculated with 1x10³ Ehrlich tumor (ET) cells. The mice were divided into three groups (n=10): CG (saline);
Rondon Tosta Ramalho +4 more
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Hypertension and Aging Affect Liver Sulfur Metabolism in Rats
Cells, 2021 Hypertension and age are key risk factors for cardiovascular morbidity and mortality. Hydrogen sulfide (H2S), a gaseous transmitter, contributes significantly to regulating arterial blood pressure and aging processes.
Dominika Szlęzak +4 more
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