Results 41 to 50 of about 3,023 (198)

The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology

The FEBS Journal, Volume 289, Issue 22, Page 6936-6958, November 2022., 2022
Coenzyme Q (CoQ) is the electron‐carrying lipid in the mitochondrial electron transport system. In mammals, it is the electron acceptor for mitochondrial dehydrogenases involved in metabolic pathways ranging from ATP synthesis, amino acid, and fatty acid oxidation to nucleotide biosynthesis, methylation, and hydrogen sulfide detoxification.
Rishi Banerjee, Janne Purhonen, Jukka Kallijärvi   +2 more
wiley   +1 more source

Histopathological evaluation of tumor necrosis and volume after cyanogenic chemotherapy [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE:To determine the percentage of tumoral necrosis and volume after cyanogenic chemotherapy.METHODS:Histopathological findings of 20 Swiss mice inoculated subcutaneously in the left abdominal wall with 0.05 ml of cell suspension containing 2.5 x 105
Rondon Tosta Ramalho, Ricardo Dutra Aydos, Iandara Schettert, Pedro Carvalho Cassino   +3 more
doaj   +1 more source

N-acetylcysteine serves as substrate of 3-mercaptopyruvate sulfurtransferase and stimulates sulfide metabolism in colon cancer cells [PDF]

, 2019
Hydrogen sulfide (H2S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides
Forte, Elena, Giardina, Giorgio, Giuffrè, Alessandro, Malagrinò, Francesca, Masi, Letizia, Paulini, Giulia, Tomé, Catarina S, Vicente, João B, Zuhra, Karim   +8 more
core   +2 more sources

Novel Characterization of Antioxidant Enzyme, 3-Mercaptopyruvate Sulfurtransferase-Knockout Mice: Overexpression of the Evolutionarily-Related Enzyme Rhodanese

Antioxidants, 2019
The antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase (MST, EC 2.8.1.2) is localized in the cytosol and mitochondria, while the evolutionarily-related enzyme, rhodanese (thiosulfate sulfurtransferase, TST, EC 2.8.1.1) is localized in the ...
Noriyuki Nagahara, Mio Tanaka, Yukichi Tanaka, Takaaki Ito   +3 more
doaj   +1 more source

Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids

Antioxidants, 2022
Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells.
Kelly Ascenção, Nahzli Dilek, Karim Zuhra, Katalin Módis, Toshiro Sato, Csaba Szabo   +5 more
doaj   +1 more source

Conformational studies on Arabidopsis sulfurtransferase AtStr1 with spectroscopic methods [PDF]

, 2007
Sulfurtransferases/rhodaneses (Str) are enzymes widely distributed in archaea, prokaryota and eukaryota, and catalyze the transfer of sulfur from a donor molecule to a thiophilic acceptor substrate.
Bartels, Andrea, Forlani, Fabio, Pagani, Silvia, Papenbrock, Jutta   +3 more
core   +1 more source

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Promoter hypomethylation and overexpression of TSTD1 mediate poor treatment response in breast cancer

Frontiers in Oncology, 2022
Epigenetic alterations play a pivotal role in cancer treatment outcomes. Using the methylation array data and The Cancer Genome Atlas (TCGA) dataset, we observed the hypomethylation and upregulation of thiosulfate sulfurtransferase–like domain containing
Muhamad Ansar, Le Thi Anh Thu, Le Thi Anh Thu, Chin-Sheng Hung, Chin-Sheng Hung, Chin-Sheng Hung, Chih-Ming Su, Chih-Ming Su, Man-Hsu Huang, Li-Min Liao, Yu-Mei Chung, Ruo-Kai Lin, Ruo-Kai Lin, Ruo-Kai Lin, Ruo-Kai Lin   +14 more
doaj   +1 more source

Past, present and future of cyanide antagonism research: From the early remedies to the current therapies. [PDF]

, 2015
This paper reviews milestones in antidotal therapies for cyanide (CN) spanning early remedies, current antidotal systems and research towards next generation therapies. CN has been a part of plant defense mechanisms for millions of years.
Budai, Marianna, Kovacs K,, Petrikovics I,, Thompson DE,   +3 more
core   +2 more sources

Protein interactions in the biological assembly of iron–sulfur clusters in Escherichia coli: Molecular and mechanistic aspects of the earliest assembly steps

IUBMB Life, Volume 74, Issue 7, Page 723-732, July 2022., 2022
Abstract This contribution focuses on the earliest steps of the assembly of FeS clusters and their insertion into acceptor apoproteins, that call for transient formation of a 2Fe2S cluster on a scaffold protein from sulfide and iron salts. For the sake of simplicity, this report is essentially limited to the Escherichia coli isc‐encoded proteins and ...
Francesco Bonomi, Stefania Iametti, Alberto Barbiroli   +2 more
wiley   +1 more source