Results 121 to 130 of about 884,746 (312)
STR profiling and Copy Number Variation analysis on single, preserved cells using current Whole Genome Amplification methods [PDF]
, 2017 The growing interest in liquid biopsies for cancer research and cell-based non-invasive prenatal testing (NIPT) invigorates the need for improved single cell analysis.
Cornelis, Senne +5 more
core +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Multiple sequence alignment and third-generation sequencing
, 2023 Le séquençage d'ADN n'a cessé d'évoluer ces dernières décennies, notamment avec l'arrivée du séquençage à haut-débit. La troisième génération de séquenceurs a produit de nouvelles données, que l'on nomme {em long reads}, qui permettent d'accéder à de nouvelles informations biologiques en surmontant les contraintes des générations précédentes, telles ...
openaire +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
The use of sequencing information in software specification for verification [PDF]
, 1983 Software requirements specifications, virtual machine definitions, and algorithmic design all place constraints on the sequence of operations that are permissible during a program's execution.
Osterweil, Leon J., Taylor, Richard N.
core +1 more source
Minimum error correction-based haplotype assembly: considerations for long read data
, 2020 The single nucleotide polymorphism (SNP) is the most widely studied type of genetic variation. A haplotype is defined as the sequence of alleles at SNP sites on each haploid chromosome.
de Ridder, Dick +2 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
International Aquatic Research, 2018 To determine changes in bacterial composition in skin ulcerations in farmed sea cucumber Apostichopus japonicus, full-length 16S rRNA gene sequencing of different skin samples of A.
Yi Yang, Yuchun Li, Zhenlin Liang
doaj +1 more source
Single-cell RNA-seq analysis of mouse preimplantation embryos by third-generation sequencing
PLoS Biology, 2020 The development of next generation sequencing (NGS) platform-based single-cell RNA sequencing (scRNA-seq) techniques has tremendously changed biological researches, while there are still many questions that cannot be addressed by them due to their short ...
Xiaoying Fan +12 more
semanticscholar +1 more source
Vitis vinefera L. DNA preparation for third-generation sequencing
, 2022 Abstract Several approaches have been proposed to sequence the genome of Vitis vinifera L. (grapevine), utilizing low-resolution second-generation platforms that lead to partial coverage and low-quality reads. Nevertheless, the characterization of the grapevine genetic resources could be better addressed through extensive and high-resolution ...
Androniki C Bibi +6 more
openaire +1 more source