Results 11 to 20 of about 660 (111)
Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins [PDF]
Virologica Sinica, 2019 Baculovirus can transduce a wide range of mammalian cells and is considered a promising gene therapy vector. However, the low transduction efficiency of baculovirus into many mammalian cells limits its practical application. Co-expressing heterologous viral glycoproteins (GPs), such as vesicular stomatitis virus G protein (VSV G), with baculovirus ...
Liangbo Hu +5 more
semanticscholar +5 more sources
Surveillance for Tick-Borne Viruses Near the Location of a Fatal Human Case of Bourbon Virus (Family Orthomyxoviridae: Genus Thogotovirus) in Eastern Kansas, 2015 [PDF]
Journal of Medical Entomology, 2018 Bourbon virus (Family Orthomyxoviridae: Genus Thogotovirus) was first isolated from a human case-patient residing in Bourbon County, Kansas, who subsequently died. Before becoming ill in late spring of 2014, the patient reported several tick bites. In response, we initiated tick surveillance in Bourbon County and adjacent southern Linn County during ...
Harry M. Savage +9 more
semanticscholar +5 more sources
Segment-specific promoter activity for RNA synthesis in the genome of Oz virus, genus Thogotovirus
VirologyOz virus (OZV), a tick-borne, six-segmented negative-strand RNA virus in the genus Thogotovirus, caused a fatal human infection in Japan in 2023. To investigate mechanisms of viral RNA synthesis, we developed an OZV minigenome assay used in mammalian ...
Lipi Akter +5 more
semanticscholar +5 more sources
Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus [PDF]
Journal of Clinical Virology, 2015 In June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing.
Amy J. Lambert +7 more
semanticscholar +5 more sources
The American Journal of Tropical Medicine and Hygiene, 2007 After intranasal, subcutaneous, or intraperitoneal infection with Dhori virus (DHOV), adult mice developed a fulminant and uniformly fatal illness with many of the clinical and pathologic findings seen in mice infected with H5N1 highly pathogenic avian ...
ROSA I. MATEO +4 more
semanticscholar +5 more sources
Virology, 2016 The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six
María Angélica Contreras-Gutiérrez +11 more
semanticscholar +5 more sources
Pathogen Spillover to an Invasive Tick Species: First Detection of Bourbon Virus in Haemaphysalis longicornis in the United States [PDF]
Pathogens, 2022 Haemaphysalis longicornis (Neumann, 1901) (Acari: Ixodidae), the Asian longhorned tick, is an invasive tick species present in the USA since at least 2017 and has been detected in one-third of Virginia counties.
Alexandra N. Cumbie +2 more
doaj +3 more sources
The American Journal of Tropical Medicine and Hygiene, 2008 Mice infected with Dhori virus (DHOV) develop a fulminant, systemic, and uniformly fatal illness that has many of the clinical and pathologic findings seen in H5N1 influenza A virus infection. However, the role of host's immune response in DHOV infection
Guangyu Li +7 more
semanticscholar +5 more sources
Reverse Vaccinology Integrated with Biophysics Techniques for Designing a Peptide-Based Subunit Vaccine for Bourbon Virus [PDF]
BioengineeringDespite the seriousness of the disease carried by ticks, little is known about the Bourbon virus. Only three US states have recorded human cases of Bourbon virus (BRBV) infection; in all cases, a tick bite was connected with the onset of the illness. The
Taghreed N. Almanaa
doaj +3 more sources
Virus Research, 2018 The genus Thogotovirus, as represented by Thogoto virus and Dhori virus, comprises a group of arthropod-borne viruses, most members of which are transmitted by ticks. Here we report the genetic and biological characterization of a new thogotovirus, designated Oz virus (OZV), isolated from the hard tick Amblyomma testudinarium in Ehime, Japan.
Hiroko Ejiri +23 more
semanticscholar +5 more sources