Results 41 to 50 of about 45,286,322 (274)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transformational Leadership and Employees’ Thriving at Work: The Mediating Roles of Challenge-Hindrance Stressors

Frontiers in Psychology, 2020
Based on previous research, the conceptual model presenting the interaction between transformational leadership, challenge-hindrance stressors and thriving at work was constructed and used to generate the hypotheses for the study. Data were obtained from
Chun pei Lin, Jialiang Xian, Baixun Li, Haimei Huang   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Pursuit of Happiness at Work: Behavior Pathway of Gen Z Employees

International Journal of Positivity & Well-Being
This study explores how young employees from Generation Z pursue happiness at work through a series of proactive and adaptive behaviors. Grounded in Self-Determination Theory, the research proposes a psychological pathway in which job crafting enhances ...
Gita Widya Laksmini Soerjoatmodjo
doaj   +1 more source

Mapping Thriving at Work as a Growing Concept: Review and Directions for Future Studies

Information, 2022
This study aims to provide a bibliometric analysis of the literature on thriving at work in psychology and business/management produced between 2001 and 2021, using the Web of Science (WoS) database.
Ghulam Abid, Francoise Contreras
doaj   +1 more source

Self-construction, work adjustment and thriving at work

International Journal of Management Development, 2011
In this article, we review and provide a framework for understanding recent research on work adjustment. Work adjustment is defined as a process rather than an outcome, and it occurs through self-and social construction. We describe two paths to work adjustment that have been identified in the organisational literature, and we provide a third path ...
Susanne G. Scott, Kellyann Berube Kowalski   +1 more
openaire   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

The Association of Volunteer Motivation and Thriving at Work of College Students During COVID-19: Job Burnout and Psychological Capital as Mediators

Frontiers in Public Health, 2022
Thriving at work is a type of mental state in which an individual feels vigorous and learning at the same time in the job. Previous studies have shown that individual internal motivation is relevant to thriving at work and volunteer behaviors, but the ...
Jun Li, Cao Ge, Shiyi Li, Shiyi Li, Shiyi Li   +4 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source