Results 121 to 130 of about 249,410 (353)

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

open access: yesAdvanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen   +11 more
wiley   +1 more source

β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock

open access: yesBiomedicines
β-adrenoceptor (β-AR) agonists are known to antagonize thrombin-induced impairment (TII) of bovine and ovine lung endothelial barrier function. The effects of adrenoceptor agonists and other vasoactive agents on human lung microvascular endothelial cell (
Michelle Y. McGee   +4 more
doaj   +1 more source

The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity

open access: yesJournal of Lipid Research, 2007
We previously reported that VLDL could transfer phospholipids (PLs) to activated platelets. To identify the metabolic pathway involved in this process, the transfer of radiolabeled PLs from VLDL (200 μM PL) to platelets (2 × 108/ml) was measured after ...
Salam Ibrahim   +4 more
doaj   +1 more source

Size‐Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano‐Nanoswitches

open access: yesAdvanced Science, EarlyView.
The fundamental principles linking nanoparticle (NP) physicochemical properties to their interactions with sonomechanical forces are not well‐defined. This work systematically investigates the size‐dependent ultrasound activation of thrombin using different‐sized mechano‐nanoswitches, which provides critical insights into the role of NP size in nano ...
Menghan Xiao   +9 more
wiley   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

open access: yesAdvanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim   +6 more
wiley   +1 more source

Percutaneous Thrombin Injection Based on Computational Fluid Dynamics of Femoral Artery Pseudoaneurysms

open access: hybrid, 2021
Hyoung‐Ho Kim   +5 more
openalex   +1 more source

Biohybrid Tendons Enhance the Power‐to‐Weight Ratio and Modularity of Muscle‐Powered Robots

open access: yesAdvanced Science, EarlyView.
Biohybrid robots powered by skeletal muscle actuators are capable of dynamically adapting to environmental cues. This study takes inspiration from native muscle–tendon architecture by leveraging tough hydrogels as synthetic tendons for muscle actuators to enhance the power‐to‐weight ratio and modularity of biohybrid machines.
Nicolas Castro   +11 more
wiley   +1 more source

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