Results 231 to 240 of about 288,586 (288)
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Thrombin and acetylated thrombin in the activation of fibrinolysis
Canadian Journal of Physiology and Pharmacology, 1968Thrombin that has been acetylated on its free amino group loses its fibrinogen-clotting properties, but when injected intravenously produces a fibrinolytic syndrome. The lytic results compare very closely to those obtained with thrombin administration, but acetylated thrombin does not produce fibrin deposition.
Elda Giavedoni +2 more
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On the inactivation of thrombin
Experientia, 1946Es wird eine Analogie zwischen der bekannten Thrombininaktivierung in Serum und dem Inaktivierungsprozes von Thrombin durch gebundenes Heparin gezeigt. Es ist moglich, das die Thrombininaktivierungsfahigkeit des Serums dem gebundenen Heparin zu verdanken ist.
L. Loránd, K. Laki
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Arteriosclerosis, Thrombosis and Vascular Biology, 2014
Objective— Activation of neutrophils by microbial or inflammatory stimuli results in the release of neutrophil extracellular traps (NETs) that are composed of DNA, histones, and antimicrobial proteins. In purified systems, cell-free DNA (CFDNA) activates
T. Gould +6 more
semanticscholar +1 more source
Objective— Activation of neutrophils by microbial or inflammatory stimuli results in the release of neutrophil extracellular traps (NETs) that are composed of DNA, histones, and antimicrobial proteins. In purified systems, cell-free DNA (CFDNA) activates
T. Gould +6 more
semanticscholar +1 more source
Thrombosis and Haemostasis, 1995
A model of thrombin interaction with distinct substrates or ligands has been derived from the crystallographic studies of thrombin-inhibitors complexes, and buttressed by functional studies with mutant thrombins, thrombin proteolytic derivatives or antibodies against thrombin.
M C, Guillin +3 more
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A model of thrombin interaction with distinct substrates or ligands has been derived from the crystallographic studies of thrombin-inhibitors complexes, and buttressed by functional studies with mutant thrombins, thrombin proteolytic derivatives or antibodies against thrombin.
M C, Guillin +3 more
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A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.
Canadian Journal of Biochemistry and Physiology, 1959The spectrophotometric procedure proposed by Schwert and Takenaka for the assay of chymotrypsin and trypsin has been modified and extended to include the application to N-benzoyl-L-tyrosine ethyl ester and α-p-toluenesulphonyl-L-arginine methyl ester ...
B. Hummel
semanticscholar +1 more source
Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection.
Analytical Chemistry, 2010Combining nanomaterials and biomolecule recognition units is promising in developing novel clinic diagnostic and protein analysis techniques. In this work, a highly sensitive and specific fluorescence resonance energy transfer (FRET) aptasensor for ...
Haixin Chang +4 more
semanticscholar +1 more source
Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation
Thrombosis and Haemostasis, 1997Thrombin mediates acute vascular thrombosis and subsequent vascular lesion formation following mechanical denuding injury or spontaneous atherosclerotic plaque rupture. In the process of generating thrombin Factor VII/VIIa binds avidly with tissue factor (TF) exposed on cellular membranes, and coagulation serine proteases are sequentially cleaved via ...
Stephen R. Hanson +2 more
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Archives of Biochemistry and Biophysics, 1961
Seegers citrate thrombin was prepared from bovine plasma and purified on IRC-50 (XE-64) resin columns at room temperature. The preparation was examined in the ultracentrifuge to determine the sedimentation coefficient and Archibald molecular weight. All measurements were made at 20 °C.
Harold A. Scheraga, Mauj A. Cohly
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Seegers citrate thrombin was prepared from bovine plasma and purified on IRC-50 (XE-64) resin columns at room temperature. The preparation was examined in the ultracentrifuge to determine the sedimentation coefficient and Archibald molecular weight. All measurements were made at 20 °C.
Harold A. Scheraga, Mauj A. Cohly
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Thrombin and vascular inflammation [PDF]
Molecular and Cellular Biochemistry, 2011 Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in ...
Popović, Milan +5 more
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Thrombin and Thrombin‐Incorporated Biomaterials for Disease Treatments
Advanced Healthcare Materials, 2023AbstractThrombin, a coagulation‐inducing protease, has long been used in the hemostatic field. During the past decades, many other therapeutic uses of thrombin have been developed. For instance, burn treatment, pseudoaneurysm therapy, wound management, and tumor vascular infarction (or tumor vasculature blockade therapy) can all utilize the unique and ...
Qiong‐Dan Zhang +3 more
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