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Targeting factor Xa and thrombin: impact on coagulation and beyond
Thrombosis and Haemostasis, 2013Summary Great advances have been made in recent years in understanding the haemostatic system and the molecular and cellular basis of thrombus formation.
C. Esmon
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Trends in Cardiovascular Medicine, 1998
Thrombin plays both procoagulant and anticoagulant roles in the blood coagulation cascade. This dual role is influenced allosterically by the binding of Na(+) near the primary specificity pocket of the enzyme. Recent findings demonstrate that it is possible to engineer recombinant thrombins that have practically lost anticoagulant activity but retain ...
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Thrombin plays both procoagulant and anticoagulant roles in the blood coagulation cascade. This dual role is influenced allosterically by the binding of Na(+) near the primary specificity pocket of the enzyme. Recent findings demonstrate that it is possible to engineer recombinant thrombins that have practically lost anticoagulant activity but retain ...
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Physical Chemistry Chemical Physics, 2007
Thrombin is a Na(+)-activated, allosteric serine protease that plays multiple functional roles in blood pathophysiology. Binding of Na(+) is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme. This review summarizes our current understanding of the molecular basis of thrombin allostery with special ...
Enrico, Di Cera +4 more
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Thrombin is a Na(+)-activated, allosteric serine protease that plays multiple functional roles in blood pathophysiology. Binding of Na(+) is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme. This review summarizes our current understanding of the molecular basis of thrombin allostery with special ...
Enrico, Di Cera +4 more
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Thrombin-soaked Coils: Estimation of Thrombin Dose
Journal of Vascular and Interventional Radiology, 1991Thrombin-soaked coils have been used as embolic agents for the treatment of various conditions. Intravascular injection of thrombin also has been used for thrombus formation; however, the effects of high doses of intravascular thrombin may be detrimental.
Gary J. Becker, Jon T. Harman
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Canadian Journal of Biochemistry and Physiology, 1957
The enzymatic properties of thrombin have been examined and compared with those of two related enzymes, plasmin and trypsin. The effects of factors such as pH, substrate specificity, ionic strength, cations, anions, and organic reagents on the enzymatic activity of thrombin have been studied. While the three enzymes discussed possess differences, such
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The enzymatic properties of thrombin have been examined and compared with those of two related enzymes, plasmin and trypsin. The effects of factors such as pH, substrate specificity, ionic strength, cations, anions, and organic reagents on the enzymatic activity of thrombin have been studied. While the three enzymes discussed possess differences, such
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Thrombosis Research, 2011
The recent development of semi-automated methods has revived interest in the thrombin generation test, a global assay that measures the overall tendency of a plasma sample to form thrombin after initiation of coagulation. The thrombin generation curve, which is characterised by a lag phase followed by the formation and subsequent inhibition of thrombin,
Elisabetta Castoldi, Jan Rosing
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The recent development of semi-automated methods has revived interest in the thrombin generation test, a global assay that measures the overall tendency of a plasma sample to form thrombin after initiation of coagulation. The thrombin generation curve, which is characterised by a lag phase followed by the formation and subsequent inhibition of thrombin,
Elisabetta Castoldi, Jan Rosing
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Acta Crystallographica Section D: Biological Crystallography, 2013
Potent second-generation thrombin aptamers adopt a duplex-quadruplex bimodular folding and recognize thrombin exosite II with very high affinity and specificity. A sound model of these oligonucleotides, either free or in complex with thrombin, is not yet
I. Russo Krauss +4 more
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Potent second-generation thrombin aptamers adopt a duplex-quadruplex bimodular folding and recognize thrombin exosite II with very high affinity and specificity. A sound model of these oligonucleotides, either free or in complex with thrombin, is not yet
I. Russo Krauss +4 more
semanticscholar +1 more source
The Role of Thrombin and Thrombin Receptors in the Brain
2008The serine protease thrombin is generated from its zymogen prothrombin. Both thrombin and prothrombin have been detected locally in the brain. Emerging evidence demonstrates that thrombin exerts physiological and pathological functions in the central nervous system.
Yingfei Wang, Georg Reiser, Weibo Luo
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Characterization of the thrombin-induced desensitization of platelet activation by thrombin
Thrombosis Research, 1983Brief exposure of platelets to thrombin makes them less sensitive to subsequent activation by thrombin, a phenomenon demonstrated by Shuman, Botney, and Fenton [J. Clin. Invest., 63, 1211-1218, 1979] by incubating prostacyclin-inhibited platelets with thrombin; after removal of thrombin and prostacyclin, the platelets were selectively desensitized to ...
Eleanor B. McGowan, Thomas C. Detwiler
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Analytical Chemistry, 2011
We presented a new aptamer biosensor for thrombin in this work, which was based on fluorescence resonance energy transfer (FRET) from upconverting phosphors (UCPs) to carbon nanoparticles (CNPs).
Yuhui Wang +3 more
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We presented a new aptamer biosensor for thrombin in this work, which was based on fluorescence resonance energy transfer (FRET) from upconverting phosphors (UCPs) to carbon nanoparticles (CNPs).
Yuhui Wang +3 more
semanticscholar +1 more source