Results 31 to 40 of about 128,976 (310)
SAveRUNNER: a network-based algorithm for drug repurposing and its application to COVID-19 [PDF]
, 2020 The novelty of new human coronavirus COVID-19/SARS-CoV-2 and the lack of effective drugs and vaccines gave rise to a wide variety of strategies employed to fight this worldwide pandemic. Many of these strategies rely on the repositioning of existing drugs that could shorten the time and reduce the cost compared to de novo drug discovery. In this study,
arxiv +1 more source
Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin
Biomolecules, 2019 Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to their spatial structure.
Elena G. Zavyalova +6 more
doaj +1 more source
Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration [PDF]
, 2018 Haemostasis is governed by a highly complex system of interacting proteins. Due to the central role of thrombin, thrombin generation and specifically the thrombin generation curve (TGC) is commonly used as an indicator of haemostatic activity. Functional characteristics of the haemostatic system in neonates and children are significantly different ...
arxiv +1 more source
Investigating biomechanical determinants of endothelial permeability in a modified hollow fibre bioreactor [PDF]
arXiv, 2023 Effects of mechanical stress on the permeability of vascular endothelium are important to normal physiology and may be critical in the development of atherosclerosis, where they can account for the patchy arterial distribution of the disease. Such properties are frequently investigated in vitro.
arxiv
Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects
Advanced Functional Materials, EarlyView.Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu +6 more
wiley +1 more source
Jornal Vascular Brasileiro, 2006 O pseudo-aneurisma (PSA) após cateterização femoral tem sido diagnosticado com regularidade em serviços com grande movimento de intervenções percutâneas, com incidência variando de 0,05 a 6%.
Daniel Mendes Pinto +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García +23 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Oral blood coagulation inhibitors and their receptors, such as factor Xa (FXa), thrombin, and the thrombin receptor protease-activated receptor 1 (PAR1), are entered into clinical trials for acute coronary syndrome therapy; however, the results obtained ...
Emiko Shinozawa +2 more
doaj +1 more source
Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy
Advanced Functional Materials, EarlyView.Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi +6 more
wiley +1 more source