Results 111 to 120 of about 47,729 (258)

Resolving Bivalirudin Interference on Fibrinogen Testing by the Use of Activated Carbon

Journal of Clinical Laboratory Analysis, EarlyView.
The influences of bivalirudin on fibrinogen assays differ considerably. Activated carbon can effectively remove bivalirudin from plasma, thereby eliminating its interference in fibrinogen detection. ABSTRACT Background Direct thrombin inhibitors may lead to falsely low fibrinogen results.
Jia Du, Haiyan Liu, Xiaohui Liu, Shuzheng Cao, Zhenlu Zhang, Litao Zhang   +5 more
wiley   +1 more source

Flow Cytometric Profiling Reveals Platelet Dysfunction and Impaired Immune Communication in Acute and Chronic Cerebrovascular Disease

Journal of Clinical Laboratory Analysis, EarlyView.
Platelets act as sensors linking inflammation and neurovascular health. Flow cytometry revealed reduced PAC‐1 in acute/subacute ICH but elevated in chronic disease, while P‐selectin remained suppressed. T lymphocyte–platelet aggregates declined across groups, indicating disrupted immune crosstalk, and these biomarkers reflect stage‐specific platelet ...
Chih‐Lung Shen, Li‐Yu Huang, Jhong‐Kuei Chen, Sheng‐Tzung Tsai, Yi‐feng Wu   +4 more
wiley   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Duplication of the prothrombin gene is associated with a significant increase in thrombin generation. [PDF]

Res Pract Thromb Haemost
Siegemund A, Siegemund T, Bönigk H, Schlosser K, Konn K, Keil S, Petros S.   +6 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

rFVIIIa-platelet binding enhances platelet procoagulant activity independently of thrombin generation. [PDF]

Blood Vessel Thromb Hemost
Strebel A, Lickert S, Klamroth R, Vogel V, Pennacchio FA.   +4 more
europepmc   +1 more source

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source

Factor VIII <i>in vitro</i> bioequivalence of denecimig (Mim8) hemostatic effect by thrombin generation assays. [PDF]

Res Pract Thromb Haemost
Lund J, Ezban M, Jensen K, Lillicrap D.
europepmc   +1 more source