Results 221 to 230 of about 3,896,793 (331)

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Thrombin generation in HeartMate 3 patients on apixaban and vitamin K antagonists: Variability limits clinical applicability. [PDF]

JHLT Open
Van Edom CJ, Droogné W, Jacobs S, Jacquemin M, Van Laer C, Van Puyvelde J, Vlasselaers D, Vandersmissen K, Vanassche T, Meyns B.   +9 more
europepmc   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Feasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms. [PDF]

Res Pract Thromb Haemost
Arisz RA, Bakker B, van den Ham R, Ahmed A, Eikenboom JCJ, Schols SEM, de Maat MPM, SYMPHONY consortium@SYMPHONY_NL.   +7 more
europepmc   +1 more source

Laboratory measurements of the oral direct factor Xa inhibitor edoxaban: comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay.

American Journal of Clinical Pathology, 2015
Y. Morishima, Chikako Kamisato
semanticscholar   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Baseline Thrombin Generation Test Does Not Predict Thrombotic Events in Acute Leukemia: A Monocentric Prospective Study. [PDF]

Mediterr J Hematol Infect Dis
Biglietto M, Mormile R, Bisegna ML, Laganà A, Faccini A, Papa A, Baldacci E, Santoro C, De Propris MS, Chistolini A.   +9 more
europepmc   +1 more source

In vivo increase in thrombin generation by four‐factor prothrombin complex concentrate in apixaban‐treated healthy volunteers

Journal of Thrombosis and Haemostasis, 2015
Y. W. Cheung, Stefano Barco, B. Hutten, J. Meijers, S. Middeldorp, M. Coppens   +5 more
semanticscholar   +1 more source

ALOX15 links lipid metabolism to receptor trafficking in platelet activation

The FEBS Journal, EarlyView.
This schematic summarizes known and newly identified mechanisms of thrombin‐mediated platelet activation. In addition to classical thrombin‐induced PAR4 signaling pathways, thrombin activates an ALOX15–HETE–PKCθ–NMT1 signaling cascade that promotes protein myristoylation, facilitates receptor trafficking, and enhances PAR4 surface expression on ...
Yosef Eshetie Amare, Sharad Saxena, Serena Zacchigna   +2 more
wiley   +1 more source

Comparative <i>ex vivo</i> analysis of Mim8 in thrombin generation assays triggered by activated factor XI or tissue factor. [PDF]

Res Pract Thromb Haemost
Ong Clausen WH, Latendorf T, Stehr R, Ezban M, Lund J.   +4 more
europepmc   +1 more source