Results 221 to 230 of about 49,195 (253)
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La Revue de medecine interne, 2016
Thrombin is a key enzyme of the coagulation cascade, having both pro- and anticoagulant functions. Global haemostasis assay, the so-called thrombin generation test is appropriate for its assessment. Estimation of an individual's potential to generate thrombin may correlate more closely with a hyper- or hypo-coagulable phenotype, compared to traditional
O, Espitia, M, Fouassier
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Thrombin is a key enzyme of the coagulation cascade, having both pro- and anticoagulant functions. Global haemostasis assay, the so-called thrombin generation test is appropriate for its assessment. Estimation of an individual's potential to generate thrombin may correlate more closely with a hyper- or hypo-coagulable phenotype, compared to traditional
O, Espitia, M, Fouassier
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Thrombin Generation Assays (TGAs)
2017In recent years, there has been a revival of interest in a time-honored tool of the clotting trade: the thrombin generation curve or thrombin generation (TG) assay (TGA) as we now call it. Thrombin generation is a key coagulation process that determines the extent of a hemostatic plug or a thrombotic process. The recent development of newer tests based
SALVAGNO, GIAN LUCA, Berntorp, Erik
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Improvements in the Thrombin Generation Test
Thrombosis and Haemostasis, 1960SummaryThe influence of glass contact on the thrombin generation test was demonstrated and a modified method described.Nearly all prothrombin had been converted to thrombin before the thrombin concentration reached its maximum.
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Thrombin generation and venous thromboembolism
Hämostaseologie, 2008SummaryVenous thromboembolism is a chronic and potential fatal disease. Determination of recurrence risk is time-consuming and costly, and sometimes not feasible: many patients carry more than one risk factor, the relevance of some factors with regard to risk of recurrence is unknown, and existence of thus far unknown risk factors must be considered. A
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Intravascular contrast media and thrombin generation
Acta Radiologica, 1994This study focuses on the effect of contrast media (CM) on thrombin generation. In vitro studies consisted of incubating nonanticoagulated whole blood with ionic CM (sodium meglumine diatrizoate, ioxaglate), nonionic CM (iohexol, iopamidol) or glucose in plastic tubes.
Z, Parvez, H, Vik
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Markers of increased thrombin generation
La Ricerca in Clinica e in Laboratorio, 1990Blood clotting activation causes an increased thrombin generation. The direct measurement of plasma thrombin is not feasible due to the absence of reliable methods. Thus, only indirect approaches are possible. Different markers of thrombin generation have been proposed in the past years. Some methods are nowadays of historical interest.
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Influence of the surface on thrombin generation
International Journal of Laboratory Hematology, 2008SummaryThrombin generation depends on the surface of the blood vessel or container. With a new ultra‐sensitive and ‐specific thrombin assay the surface‐dependent thrombin generation was quantified. Citrated blood or plasma was preincubated for 1 h (37 °C).
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Thrombin Generation in Pregnancy
2008A well functioning hemostasis depends on the well-balanced interaction between many procoagulatory and inhibiting factors of the coagulation and the fibrinolytic system. During normal pregnancy this balance is shifted towards a state of hypercoagulability [1], which is more marked around term and in the immediate post partum period [2].
A. Rosenkranz +7 more
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A Modification of the ‘Thrombin Generation Test’
Acta Haematologica, 2009E T, VAN DER POL +2 more
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Thrombin Generation by Valproate
2019Pathological plasmatic thrombin generation can lead to many complications such as thrombotic/atherosclerotic diseases. The contact phase of blood coagulation can be triggered by low plasma concentrations of lipophilic or negatively charged groups. There are two main proteases that can start the whole intrinsic coagulation cascade: activated factor 12 ...
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