Results 211 to 220 of about 49,195 (253)
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Thrombin Generation and the Pathogenesis of Cancer
Seminars in Thrombosis and Hemostasis, 2006Advanced cancer is associated with a hypercoagulable state that is triggered by tissue factor (TF). TF-initiated thrombin generation is crucial for metastasis through fibrin and platelet deposition, as well as thrombin-dependent protease-activated receptor (PAR) 1 signaling. Surprisingly, PAR2, which is not cleaved by thrombin, appears to cosignal with
Wolfram, Ruf, Barbara M, Mueller
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Thrombin generation: phenotypic quantitation
Journal of Thrombosis and Haemostasis, 2004An individual's ability to generate thrombin following tissue factor stimulus was evaluated in 13 healthy male donors in a 6-month study. Thrombin generation in whole blood collected by phlebotomy, contact pathway suppressed by the presence of 100 micro g mL-1 corn trypsin inhibitor, was initiated by the addition of 5 pm tissue factor/10 nm ...
K E, Brummel-Ziedins +2 more
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Thrombin generation in rheumatoid arthritis
Joint Bone Spine, 2012Joint Bone Spine - In Press.Proof corrected by the author Available online since samedi 2 juin ...
Clément, Prati +4 more
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Thrombin generation in severe sepsis
Thrombosis Research, 2012Hemostasis and inflammation are two tightly interrelated systems in the host's response to infection. Thrombin generation in sepsis plays a crucial role in enhancing and modulation of inflammation. The present study aimed to investigate the course of thrombin generation in patients with severe sepsis, and its correlation with outcome.Thrombin ...
S, Petros +3 more
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Thrombin generation by hemolysis
Blood Coagulation & Fibrinolysis, 2007Hemolysis is the fragmentation of erythrocytes into microparticles (Hb-MP). Clinical hemolysis can result in a severe procoagulant state. The influence of Hb-MP on thrombin generation was quantified. Unfrozen citrated normal plasma (five donors) was supplemented with 0 or 1 g/l Hb-MP obtained through erythrocyte destruction by hypotonic lysis, freezing/
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Control Mechanisms in Thrombin Generation
Seminars in Thrombosis and Hemostasis, 1996Thrombin accelerates its own production by activating platelets (and perhaps other cells) to provide coagulant surfaces on which prothrombinase, the enzyme complex that activates prothrombin in plasma and consists of equimolar factor Xa (serine protease) and factor Va (cofactor), assembles in a Ca(2+)-dependent reaction.
F A, Ofosu, L, Liu, J, Freedman
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Thrombin Potential and Thrombin Generation After Exhaustive Exercise
International Journal of Sports Medicine, 2002Exhaustive exercise leads to an activation of blood coagulation, but the implications of this activation are still unclear. The aim of this study was to investigate if a hypercoagulant stage exists after exhaustive treadmill- or cycle exercise; intrinsic and extrinsic endogenous thrombin potential (ETP) were measured by using the method of Hemker et al.
T, Hilberg +4 more
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Thrombin generation in ankylosing spondylitis
Clinical Rheumatology, 2010Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with an increase in cardiovascular risk. Thrombin generation is associated with the risk of thrombosis, and the endogenous thrombin potential (ETP) has been proposed as a parameter for plasma-based hypercoagulability.
Clément, Prati +3 more
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Thrombin generation in clinical conditions
Thrombosis Research, 2012Commercial assays for determining thrombin generation in plasma are being tested in clinical conditions associated with thrombosis or bleeding. While pre-analytical conditions remain a source of inter laboratory variation, demanding for further standardization, clinical research proceeds. In patients at risk of venous thrombosis thrombin generation (TG)
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Thrombin generation in antiphospholipid syndrome
Lupus, 2012Our objective was to study acquired Activated Protein C (APC) resistance in patients with antiphospholipid antibodies (aPL) using a thrombin generation based assay. We compared patients with and without lupus (systemic lupus erythematosus, SLE).
S, Zuily +5 more
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