Results 211 to 220 of about 3,896,793 (331)

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Emicizumab, the factor VIII mimetic bispecific monoclonal antibody: effects on thrombin generation and thromboelastometry. [PDF]

Res Pract Thromb Haemost
Tripodi A, Clerici M, Scalambrino E, Arcudi S, Gualtierotti R, Novembrino C, Peyvandi F.   +6 more
europepmc   +1 more source

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.

Blood, 2015
E. Mammadova-Bach, V. Ollivier, S. Loyau, Mathieu Schaff, B. Dumont, R. Favier, G. Freyburger, V. Latger‐Cannard, B. Nieswandt, C. Gachet, P. Mangin, M. Jandrot-Perrus   +11 more
semanticscholar   +1 more source

Mechanistic insights into HapC: A key enzyme in prodiginine biosynthesis in Hahella chejuensis

The FEBS Journal, EarlyView.
HapC catalyzes prodiginine biosynthesis through coordinated movements of its ATP‐binding, substrate‐binding, and catalytic‐swivel domains. The enzyme shows tolerance toward short‐chain MAP analogs, and docking analyses reveal key residues and structural features underlying its substrate flexibility.
Yueh‐Te Chan, Aden Dhana Rizkita, Hsin‐Ju Hsieh, Shu‐Fang Hsu, Tony Eight Lin, Wei‐Jan Huang, Kai‐Cheng Hsu, Sheila Nathan, Peiching Chang, Andrew H.‐J. Wang, Cheng‐Chung Lee   +10 more
wiley   +1 more source

Allosteric and ATP-Pocket BCR::ABL1 Inhibition In Vitro, and Characterising Ex Vivo Thrombo-Inflammatory Biomarkers and Thrombin Generation in Asciminib-Treated CML Patients. [PDF]

Int J Mol Sci
Omar MMA, Alanazi MA, Yeung DT, Hughes TP, Jackson DE.   +4 more
europepmc   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Effect of hyperthermic intraperitoneal chemotherapy on thrombin generation and fibrinolysis. [PDF]

Int J Colorectal Dis
Lundbech M, Krag AE, Iversen LH, Brandsborg B, Hvas AM.   +4 more
europepmc   +1 more source

Calibrated Automated Thrombin Generation Measurement in Clotting Plasma

Pathophysiology of Haemostasis and Thrombosis, 2003
H. Coenraad Hemker, P. Giesen, R. al Dieri, V. Regnault, Eric de Smedt, R. Wagenvoord, T. Lecompte, S. Béguin, H. Hemker   +8 more
semanticscholar   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

High incidence of thrombin generation resistance to thrombomodulin in patients with unprovoked venous thromboembolism. [PDF]

Blood Vessel Thromb Hemost
Gris JC, Chea M, Nouvellon E, De Jouvancourt R, Fortier M, Bourguignon C, Laurent J, Bouvier S, Perez-Martin A.   +8 more
europepmc   +1 more source