Results 191 to 200 of about 3,896,793 (331)

Anticoagulation Strategies in Adults Undergoing Extracorporeal Membrane Oxygenation: A Systematic Review and Meta‐Analysis

Artificial Organs, EarlyView.
In this meta‐analysis of 2 775 adult ECMO patients from non‐randomized studies, direct thrombin inhibitors and low‐molecular‐weight heparins demonstrated a favorable efficacy and safety profile over unfractionated heparin. These findings suggest them to be effective alternatives to unfractionated heparin, underscoring the urgent need for randomized ...
Vincenz Scharner, Karoline Lenz, Harald Herkner, Nina Buchtele, Thomas Staudinger, Eva Schaden, Marion Wiegele, Johannes Gratz   +7 more
wiley   +1 more source

Thrombin Generation in Pediatric Haemophilia A Patients on Extended Half-Life FVIII versus Non-FVIII Therapies. [PDF]

Haemophilia
Garcia J, Yates SG, Sarode R, Young G, Zia A.   +4 more
europepmc   +1 more source

Thrombin Generation Assay and Its Application in the Clinical Laboratory.

Clinical Chemistry, 2016
A. Tripodi
semanticscholar   +1 more source

The impact of systemic long‐term medications for the development of age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä, Reijo Sund, Toni Rikkonen, Kai Kaarniranta   +3 more
wiley   +1 more source

Perioperative thrombin generation and fibrinolytic activation in patients undergoing major gynaecologic surgery for benign and malignant pathology: a pilot study. [PDF]

BJA Open
Thiele EL, Forkin KT, Ring KL, Tsang S, Osuru H, Mazzeffi MA.   +5 more
europepmc   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Plasma Tissue Factor Pathway Inhibitor Levels Correlate with Disease Activity and Are Associated with Altered Thrombin Generation in Pediatric Inflammatory Bowel Disease. [PDF]

Pharmaceuticals (Basel)
Meyer A, Kohlmaier B, Bauer T, Gallistl S, Muntean W, Silbernagel B, Haidl H, Schlagenhauf A.   +7 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

rFVIIIa-platelet binding enhances platelet procoagulant activity independently of thrombin generation. [PDF]

Blood Vessel Thromb Hemost
Strebel A, Lickert S, Klamroth R, Vogel V, Pennacchio FA.   +4 more
europepmc   +1 more source

Thrombin generation and cell‐dependent hypercoagulability in sickle cell disease

Journal of Thrombosis and Haemostasis, 2016
M. Whelihan, M.-Y. Lim, Micah J. Mooberry, Mark Piegore, A. Ilich, A. Wogu, J. Cai, D. Monroe, K. Ataga, K. Mann, N. Key   +10 more
semanticscholar   +1 more source