Results 181 to 190 of about 49,195 (253)

Correlation Between Thrombin Generation and Hepatic Fibrosis in Chronic Liver Diseases. [PDF]

Cureus
Vecerzan L, Maniu I, Cioca G.
europepmc   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

Age- and sex-dependency of thrombin generation parameters in the general Italian population: the Moli-sani study. [PDF]

Front Cardiovasc Med
Costanzo S, de Laat B, Di Castelnuovo A, van der Vorm L, De Curtis A, Cerletti C, Ninivaggi M, Donati MB, Iacoviello L, de Laat-Kremers R, Moli-sani investigators.   +10 more
europepmc   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Risk of First Venous Thrombosis by Comparing Different Thrombin Generation Assay Conditions: Results from the MEGA Case-control Study. [PDF]

TH Open
Winckers K, Biguzzi E, Thomassen S, Heinzmann A, Rosendaal FR, Hackeng TM, van Hylckama-Vlieg A.   +6 more
europepmc   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Decreased Thrombin Generation is Associated with Increased Thrombin Generation Biomarkers and Blood Cellular Indices in Pulmonary Embolism. [PDF]

Clin Appl Thromb Hemost
Siddiqui F, Tafur A, Darki A, Kantarcioglu B, Hoppensteadt D, Krupa E, Iqbal O, Fareed J, Monreal M.   +8 more
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Extent of peritoneal metastases from colorectal cancer is not associated with changes in thrombin generation or fibrinolysis. [PDF]

Pleura Peritoneum
Lundbech M, Krag AE, Iversen LH, Brandsborg B, Hvas AM.   +4 more
europepmc   +1 more source