Results 71 to 80 of about 3,126,313 (204)

Essential Thrombocythemia and Acquired von Willebrand Syndrome: The Shadowlands between Thrombosis and Bleeding

Cancers, 2020
Over the past decade, new insights have emerged on the pathophysiology of essential thrombocythemia (ET), its clinical management, and associated thrombohemostatic disturbances.
H. Awada, M. Voso, P. Guglielmelli, C. Gurnari   +3 more
semanticscholar   +1 more source

Population Pharmacokinetics and Exposure–Response Analyses of Momelotinib, Its Active Metabolite (M21), and Total Active Moiety in Myelofibrosis

Clinical Pharmacology &Therapeutics, EarlyView.
Momelotinib, a Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor, is approved for the treatment of myelofibrosis with anemia. These analyses characterized the population pharmacokinetics of momelotinib and its active metabolite M21 following administration of the commercial tablet formulation in patients with myelofibrosis from phase II/III
Benjamin Rich, Meenakshi Srinivasan, Yu Liu Ho, Sandra A.G. Visser, Geraldine Ferron‐Brady, Georgios Vlasakakis   +5 more
wiley   +1 more source

A case of essential thrombocythemia and ankylosing spondylitis treated with a combination of anagrelide, disease-modifying antirheumatic drugs, and etanercept [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2016
Introduction. A high platelet count, or thrombocytosis, is either a reactive process or a result of a myeloproliferative disorder. Ankylosing spondylitis is a chronic inflammatory rheumatic disease affecting the spine and sometimes peripheral ...
Zeremski Vanja, Savić Aleksandar, Ilić Tatjana, Milošević Ivana, Maksimović Marina, Vučković Biljana   +5 more
doaj   +1 more source

Polycythemia Vera and Essential Thrombocythemia: A Nationwide Population‐Based Study on Treatment Patterns, Vascular Complications and Survival

European Journal of Haematology, EarlyView.
ABSTRACT Background Polycythemia vera (PV) and essential thrombocythemia (ET) are associated with a well‐recognized increased risk of thrombotic events, bleeding, and all‐cause mortality, but the frequency of these outcomes during treatment has rarely been assessed in large cohorts.
Anneli Enblom Larsson, Henrik Renlund, Björn Andréasson, Henrik Holmberg, Maria Liljeholm, Anders Själander   +5 more
wiley   +1 more source

Pathophysiological aspects of Platelet-Mediated Thrombosis and Bleeding in Essential Thrombocythemia: [PDF]

, 1998
Thrombocytosis, i.e. an elevation of the platelet count, is a common finding in clinical practice. In general, patients with thrombocytosis are distinguished into two main categories, primarily based on the cause underlying the increased platelet count ...
Genderen, P.J.J. (Perry) van
core   +1 more source

Essential Thrombocythemia

Siriraj Medical Journal, 2002
This is a review of twelve cases of Essential Thrombocythemia at Suratthani Hospital, aged between 48 to 87 years old, 6 male and 6 female. The initial clinical presentations were as follows: 2 asymptomatic cases (incidentally found on routine CBC check ...
Kanchanee Janwanitsthaporn
doaj  

Multinational transfusion practices and outcomes in haematology patients admitted to the intensive care unit

Vox Sanguinis, EarlyView.
Abstract Background and Objectives The number of critically ill patients with haematological conditions is increasing, yet transfusion practices in this population remain poorly defined. This study aimed to compare transfusion strategies in critically ill patients with versus without haematological conditions.
Caroline M. Schaap, Laurens A. Oomen, Senta Jorinde Raasveld, Jimmy Schenk, Sanne de Bruin, Merijn C. Reuland, Claudia van den Oord, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Zoe McQuilten, Thomas W. L. Scheeren, Cécile Aubron, Andrew W. J. Flint, Tarikul Hamid, Michaël Piagnerelli, Tina Tomić Mahečić, Jan Benes, Lene Russell, Hernan Aguirre‐Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V. Llau, Manual Quintana‐Diaz, Maria Cronhjort, Carmen A. Pfortmueller, Nihan Yapici, Nathan Nielsen, Harm‐Jan de Grooth, Alexander P. J. Vlaar, Bart J. Biemond, Akshay Shah, Marcella C. A. Müller, InPUT Study Group, Alisa Higgins, Ary Serpa Neto, Karina Brady, Erica Wood, Alexis Poole, Tony Trapani, Meredith Young, Jamie Cooper, Paul Secombe, Graham Reece, Prashanti Marella, David Brewster, Alan Rashid, Ruwan Suwandarathne, Raman Azad, Jonathan Barrett, Elisha Turner, Amber‐Louise Poulter, Lixian Chen, Vishwanath Biradar, Christina Whitehead, Sandra Peake, Alexis Tabah, Stephanie O'Connor, Michael Reade, Guido Janssen, Richard McAllister, Katherine Triplett, David Bowen, Hergen Buscher, John Santamaria, Dinesh Parmar, Paul Power, Craig French, David Bowen, Matthew Mac Partlin, David Bowen, Md Motiul Islam, Injamam Ull Haque, Alain Roman, Višnja Ikic, Slavica Kvolik, Robert Bojčić, Kazimir Juričić, Martin Duksa, Lukáš Bílek, Igor Satinsky, Jan Zatloukal, Lene Russell, Morten H. Bestle, Christian S. Meyhoff, Ana Maria Diaz‐Medina, Verónica Llumiquinga, Hernán Aguirre‐Bermeo, Heinert Enmanuel Gonzabay‐Campos, Mohamed Elbahnasawy, Xavier Chapalain, Charlène Le Moal, Pierre‐Yves Egreteau, Yoann Launey, Florian Reizine, Florence Boissier, Reignier Jean, Stephan Ehrmann, Eddy Lebas, Gaelle Corno, Pauline Cailliez, Pierre Garçon, Guillaume Carteaux, Antoine Kimmoun, Johann Auchabie, Danai Theodoulou, Stavros Aloizos, Eleftherios Papadakis, Konstantinos Tsakalis, Giorgos Marinakis, Ioannis Georgakas, Paraskevi Tripolitsioti, Sofia Nikolakopoulou, Georgios Papathanakos, Evangelia Tsika, Ourania Mousafiri, Athanasios Prekates, Georgia Micha, Athina Lavrentieva, Theodoros Aslanidis, Athina Palaiologou, Clementine Bostantzoglou, Evangelia Dikoudi, Silia Karaouli, Sophia Pouriki, Swapna Vijayakumaran, Darshana Rathod, Venkat Raman Kola, Deepak Jeswani, Gopalakrishna Kadarapura Nanjundaiah, Amol Hartalkar, Ata Mahmoodpoor, Marwah Abdulkhaleq, Mariachiara Ippolito, Antonella Cotoia, Marco Covotta, Sanfilippo Filippo, Ehab Ishteiwy, Hebtallah Benzarti, Ahmed Elmabri Mohammed Bouhuwaish, Alya Abdalhadi, Ahmad Buimsaedah, Eman Ali Abdulwahed, Khalil Tamoos, Eman Younes, Asma Abubakr Saleh Alkamkhe, Marwa Biala, Hajer Abdalla Mohammed Hwili, Najat Shaban Ben Hasan, Bushray Alhadi Almiqlash, Mawadda Altair, Rema Otman, Mohamed Fathi Al Gharyani, Omlez Mohammed Alkeelani, Hibah Bakeer, Azah Mukhtar Omar Affat, Husayn Aween, Aihab Benamwor, Mohamed Alsori, Najwa Abdelrahim, GHANNAM Abdelilah, Rachael Parke, Yan Chen, Jan Mehrtens, Pawel Twardowski, Ross Freebairn, Rima Song, Charles Gibson, Jonathan Chen, Richard Moore, Mary Rose Sol Cruz, Anna Wludarczyk, Łukasz Krzych, Marta Szczukocka, Marcin Kubiak, Maciej Molsa, Magdalena Wujtewicz, Agnieszka Wieczorek, Agnieszka Misiewska‐Kaczur, Dariusz Onichimowski, Jakub Mazur, Pawel Zatorski, Ana Marta Mota, Joana Fernandes, Diana Castro, Elisabete Coelho, Alexandra Paula, Teresa Guimarães, Diana Adrião, Igor Mark, Elizabeta Mušič, Tomislav Mirković, Andrej Markota, Natalija Krope, Marko Kmet, Petra Forjan, Tomaž Savli, Gerardo Aguilar, Rebeca González‐Celdrán, Estefanía Martínez‐González, Agustín Díaz, María José Colomina, Francisco Hidalgo, Carlos Ferrando, Raquel Ferrandis, Carolina Ferrer, Virginia Cegarra, Aurelio Gómez‐Luque, Stina Henman, Disa Blomstrand, Emelie Risberg, Natalie Johansen, Henrik Rajala, Natalie Layous, Eline A. Vlot, Michiel Erkamp, Nicole Juffermans, Claudia van den Oord, Jimmy Schenk, Merijn Reuland, Stefan van Wonderen, Caroline Schaap, Lidija Kuznecova‐Keppel Hesselink, Victor van Bochove, Murat Acarel, Evren Senturk, Mahmut Alp Karahan, Aynur Camkiran Firat, Yahya Yildiz, Osman Ekinci, Asu Ozgultekin, Huseyin Arikan, Gamze Kucukosman, Bengu Gulhan Aydin, Mehmet Yavuz, Alev Oztas, Nilgun Kavrut Ozturk, Umut Sabri Kasapoglu, Hakan Miniksar, Eylem Tuncay, Cenk Indelen, Halide Ogus, Basar Erdivanli, Ayca Sultan Sahin, Mehmet Yilmaz, Erken Sayan, Canan Yilmaz, Senay Goksu, Betul Basaran, Emine Kutahya, Ayfer Kaya Gok, Ayse Ozcan, Iskender Kara, Seyfi Kartal, Kemal Tolga Saracoglu, Yeliz Bilir, Selin Eyupoglu, Nigar Ertugrul Oruc, Kubilay Issever, Jamie Patel, Jayson Clarke, Louise Ma, Tom Lawton, Brendan Sloan, Santhana Kannan, Richard Innes, Mark Carpenter, Luke Newey, Hazem Alwagih, Chris Acott, Anil Hormis, James Herdman, Osama Akrama, Rachel Baumber, Olena Khomenko, Akram Khan, Zubair Hasan, Jay S. Raval, Lauren Sutherland   +288 more
wiley   +1 more source

Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance TPO is a cytokine that signals through the receptor MPL (or TPO-R), and is essential for megakaryocyte differentiation and maintenance of hematopoietic stem cells (HSCs). TPO signaling is deregulated in essential thrombocythemia (ET).
Lu Cui, Ignacio Moraga, Tristan Lerbs, Camille van Neste, S. Wilmes, N. Tsutsumi, Aaron Claudius Trotman-Grant, Milica Gakovic, Sarah Andrews, J. Gotlib, S. Darmanis, M. Enge, S. Quake, I. Hitchcock, J. Piehler, K. Garcia, G. Wernig   +16 more
semanticscholar   +1 more source

Pretreatment with Hydroxyurea of the Patient with Essential Thrombocythemia Followed by Coronary Artery Bypass Surgery

Oman Medical Journal, 2014
The risk of thrombosis is high in patients with essential thrombocythemia. Special precaution needed for those patients who will undergo Coronary artery bypass grafting. We are reporting a 62 years old patient with ischemic heart disease who was found to
Edem Ziadinov, Hilal Al-Sabti, Malik Al-Toubi, Mohammad Salman Siddiqi   +3 more
doaj   +1 more source

Triple-Negativity Identifies a Subgroup of Patients with Better Overall Survival in Essential Thrombocythemia

Hematology Reports, 2022
Essential thrombocythemia, as defined by the WHO in 2016, is a Philadelphia-negative chronic myeloproliferative neoplasm showing a better prognosis than polycythemia vera and myelofibrosis.
Marco Santoro, Vincenzo Accurso, Salvatrice Mancuso, Mariasanta Napolitano, Marta Mattana, Giorgia Vajana, Federica Russello, Sergio Siragusa   +7 more
doaj   +1 more source