Results 81 to 90 of about 28,500 (228)

Evaluation of thrombomodulin (THBD) plasma levels in sickle cell disease and correlation with disease severity

Egyptian Pediatric Association Gazette
Background Endothelial dysfunction is a hallmark of sickle vasculopathy. Thrombomodulin (THBD) is a transmembrane protein expressed on vascular endothelial cells suppressing blood coagulation and exerting anti-inflammatory effects.
Yasmeen M.M. Selim, Amina Abdelsalam, Eman A. Youssef, Abdelkarem Bahy, Dalia El-Sayed   +4 more
doaj   +1 more source

Recombinant Human Soluble Thrombomodulin Suppresses Monocyte Adhesion by Reducing Lipopolysaccharide-Induced Endothelial Cellular Stiffening

Cells, 2020
Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation.
Takayuki Okamoto, Eiji Kawamoto, Haruki Usuda, Tetsuya Tanaka, Tetsuro Nikai, Kunihiro Asanuma, Koji Suzuki, Motomu Shimaoka, Koichiro Wada   +8 more
doaj   +1 more source

Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Cerebral cavernous malformations (CCMs) are vascular lesions in the brain caused by inherited genetic mutations in the CCM1/2/3 genes that disrupt normal blood vessel function. This work demonstrates that these mutations lead to endothelial dysfunction, inflammation, and iron accumulation, which can be detected by magnetic resonance imaging (MRI) and ...
Fabrícia Lima Fontes‐Dantas, Gustavo da Fontoura Galvão, Alexandre Martins Cunha, Pedro de Sena Murteira Pinheiro, Verônica Morandi, Jorge Marcondes de Souza   +5 more
wiley   +1 more source

Nonlinear and Age‐Specific Associations Between Atherogenic Index of Plasma and Differential Cardiovascular Risk Profiles in US Adults

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Background The association between the atherogenic index of plasma (AIP) and different cardiovascular disease (CVD) outcomes remains insufficiently studied. Methods Data from 16,302 US adults in NHANES 2005–2020 were analyzed. CVD outcomes included congestive heart failure, coronary heart disease, angina, heart attack, and stroke.
Yuelin Hu, Xuli Chen, Yanchao Liu, Qiuyu Wang, Wenwen Xiao, Arquimedes Gasparotto Junior   +5 more
wiley   +1 more source

Reciprocal antagonism between inflammation and the protein C system

Romanian Journal of Laboratory Medicine, 2013
Proteina C, o protează serinică dependentă de vitamina K, sintetizată in hepatocite ca zimogen inactiv, se activează sub acţiunea trombinei în complex cu trombomodulina endotelială. Un receptor endotelial al proteinei C (EPCR) intervine atât în activarea
Cucuianu Mircea, Brudasca Ioana, Plesca Luminita, Bodizs Gyorgy, Colhon Dan, Cucuianu Andrei   +5 more
doaj   +1 more source

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

Research and Practice in Thrombosis and Haemostasis, 2020
Background The efficacy and safety of thrombomodulin alfa (TM‐α), a cofactor protein promoting thrombin‐mediated protein C activation, have been examined in a phase 3 randomized, double‐blinded, parallel‐group trial in Japan.
Takashi Ito, Ikuro Maruyama, Shuji Shimazaki, Yasuhiro Yamamoto, Naoki Aikawa, Akio Hirayama, Goichi Honda, Hidehiko Saito   +7 more
doaj   +1 more source

Endothelial cell and hemostatic activation in relation to cytokines in patients with sepsis [PDF]

, 1999
Sepsis is commonly associated with disturbances of the hemostatic balance. Most of the pathophysiological changes in sepsis are caused by endotoxin acting directly through endothelial injury or indirectly through release of cytokines with procoagulant ...
Lopez-Aguirre, Y. (Yolanda), Paramo, J.A. (José Antonio)   +1 more
core   +1 more source

A Review of Emerging Biomarkers Connecting Diabetes and Ischemic Stroke: Implications for Early Detection and Risk Stratification

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetes substantially increases the risk of ischemic stroke through complex metabolic, inflammatory, and vascular mechanisms, yet early identification of high‐risk individuals remains challenging. This narrative review synthesizes emerging circulating and genomic biomarkers that illuminate the pathways linking diabetes and ischemic stroke and ...
Nadia Hussain, Azza Ramadan, Amal Hussain Ibrahim Al Haddad, Zina Alfahl, Kenneth Lo   +4 more
wiley   +1 more source

Low Vitamin D Serum Level Is Associated with HDL-C Dyslipidemia and Increased Serum Thrombomodulin Levels of Insulin-Resistant Individuals

Diabetes, Metabolic Syndrome and Obesity, 2020
Fatemeh Saheb Sharif-Askari,1 Narjes Saheb Sharif-Askari,1 Rabih Halwani,1,2 Salah Abusnana,2,3 Rifat Hamoudi,1,2 Nabil Sulaiman1,4,5 1Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates ...
Saheb Sharif-Askari F, Saheb Sharif-Askari N, Halwani R, Abusnana S, Hamoudi R, Sulaiman N   +5 more
doaj  

Whole exome sequencing identifies a mutation in thrombomodulin as the genetic cause of a suspected platelet disorder in a family with normal platelet function

Platelets, 2017
Here, we describe a mother and son with a lifelong bleeding tendency and posttraumatic bleeding who were recruited to the UK Genotyping and Phenotyping of Platelets (GAPP) study with a suspected platelet function disorder.
Annabel Maclachlan, Gerry Dolan, Charlotte Grimley, Steve P. Watson, Neil V. Morgan, on behalf of the UK GAPP Study Group   +5 more
doaj   +1 more source