Results 1 to 10 of about 7,460 (217)
Altered thrombopoiesis in spontaneously hypertensive rats [PDF]
Scientific ReportsPlatelet hyperreactivity is a risk factor for cardiovascular disease development and mortality in hypertensive patients. Although several studies have linked platelet hyperreactivity with increased bone marrow thrombopoiesis, extramedullary ...
Isaac Rojo +8 more
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Nature Communications, 2020 Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.
Leonardo Rivadeneyra +2 more
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Toll-like Receptors and Thrombopoiesis
International Journal of Molecular Sciences, 2023 Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia is a common hematologic problem in the clinic, and it
Jiesi Luo, Wu An Guo, Jian-Ming Wu
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Piggyback knockdown screening of unique genes of zebrafish young thrombocytes identifies eight novel genes in thrombopoiesis [PDF]
Scientific ReportsPlatelet production, or thrombopoiesis, is a critical process involving the differentiation of hematopoietic stem cells into megakaryocytes, which release platelets into circulation.
Weam Fallatah +4 more
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Nature Communications, 2023 Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM.
Zhenhao Liu, Jian Li, Lugui Qiu
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α-Actinin-1 in Megakaryocytes: Its Structure, Interacting Proteins and Implications for Thrombopoiesis [PDF]
BiomedicinesMutations in the ACTN1 gene, which encodes the cytoskeletal protein α-actinin-1, have been implicated in the etiology of autosomal dominant congenital macrothrombocytopenia.
Lanlan Wu +4 more
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The Thrombopoietic Signature of Preeclampsia: Diagnostic and Monitoring Insights from the Immature Platelet Fraction [PDF]
DiagnosticsBackground: Preeclampsia is a major obstetric disorder characterized by platelet activation and dysregulated thrombopoiesis. While conventional platelet indices reflect platelet morphology, the immature platelet fraction (IPF) provides insight into ...
Ilkay Er +3 more
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Thrombocytopenia in dengue infection: mechanisms and a potential application [PDF]
Expert Reviews in Molecular MedicineThrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms.
Ahmad Suhail Khazali +4 more
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Historical review: megakaryopoiesis and thrombopoiesis [PDF]
Blood, 2008 Abstract The study of thrombopoiesis has evolved greatly since an era when platelets were termed “the dust of the blood,” only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the primary ...
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Enhanced thrombopoiesis supplies PD-L1 to circulating immune cells via the generation of PD-L1-expressing platelets in patients with lung cancer [PDF]
Journal for ImmunoTherapy of CancerBackground The increased expression of programmed cell death ligand 1 (PD-L1) on a subset of immune cells in the peripheral blood has been frequently observed in patients with cancer, suggesting a relationship with PD-L1 expression in tumor tissues.
Sung-Woo Lee +14 more
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