Results 11 to 20 of about 7,460 (217)

Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture [PDF]

Nature Communications, 2016
Although Mg2+is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the ...
Simon Stritt, Paquita Nurden, Rémi Favier   +2 more
exaly   +7 more sources

Beyond energy: Mitochondrial control of platelet lifecycle through redox, calcium, and dynamics [PDF]

Redox Biology
Platelet disorders, caused by quantitative deficiencies or functional impairments, significantly contribute to cardiovascular, neurological, and iatrogenic pathologies. Although platelets are indispensable for hemostasis, thrombosis, and immune responses,
Xinle Wang, Rui Liao, Qihang Huang, Jingyan Li, Xiang Li, Xiaolin Gan, Yiwei Wang, Chunling Zhao, Qibing Mei, Jianping Chen, Anguo Wu, Xiaogang Zhou, Jianming Wu   +12 more
doaj   +2 more sources

Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway [PDF]

Journal of Pharmaceutical Analysis
Radiation-induced thrombocytopenia (RIT) faces a perplexing challenge in the clinical treatment of cancer patients, and current therapeutic approaches are inadequate in the clinical settings.
Chengyang Ni, Ling Zhou, Shuo Yang, Mei Ran, Jiesi Luo, Kui Cheng, Feihong Huang, Xiaoqin Tang, Xiang Xie, Dalian Qin, Qibing Mei, Long Wang, Juan Xiao, Jianming Wu   +13 more
doaj   +2 more sources

Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis

Frontiers in Immunology, 2023
Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and related to many cellular events including apoptosis ...
Shuo Yang, Long Wang, Yuesong Wu, Anguo Wu, Anguo Wu, Feihong Huang, Feihong Huang, Xiaoqin Tang, Fahsai Kantawong, Songyot Anuchapreeda, Dalian Qin, Qibing Mei, Qibing Mei, Jianping Chen, Xinwu Huang, Chunxiang Zhang, Jianming Wu, Jianming Wu, Jianming Wu   +18 more
doaj   +1 more source

Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia

Therapeutic Advances in Hematology, 2023
Platelets, derived from a certain subpopulation of megakaryocytes, are closely related to hemostasis, coagulation, metastasis, inflammation, and cancer progression.
Lejun Huang, Jianxuan Xu, Huaying Zhang, Mengfan Wang, Yiyue Zhang, Qing Lin   +5 more
doaj   +1 more source

Multiphoton In Vivo Microscopy of Embryonic Thrombopoiesis Reveals the Generation of Platelets through Budding

Cells, 2023
Platelets are generated by specialized cells called megakaryocytes (MKs). However, MK’s origin and platelet release mode have remained incompletely understood.
Huan Liu, Hellen Ishikawa-Ankerhold, Julia Winterhalter, Michael Lorenz, Mykhailo Vladymyrov, Steffen Massberg, Christian Schulz, Mathias Orban   +7 more
doaj   +1 more source

Mechanisms of thrombopoiesis [PDF]

Journal of Thrombosis and Haemostasis, 2005
Megakaryocytes (MKs) expand and differentiate over several days in response to thrombopoietin (Tpo) before releasing innumerable blood platelets. The final steps in platelet assembly and release represent a unique cellular transformation that is orchestrated by a range of transcription factors, signaling molecules, and cytoskeletal elements.
H, Schulze, R A, Shivdasani
openaire   +2 more sources

Airborne particulate matters induce thrombopoiesis from megakaryocytes through regulating mitochondrial oxidative phosphorylation

Particle and Fibre Toxicology, 2021
Background Although airborne fine particulate matter (PM) pollution has been demonstrated as an independent risk factor for pulmonary and cardiovascular diseases, their currently-available toxicological data is still far from sufficient to explain the ...
Xiaoting Jin, Hongyan Yu, Baoqiang Wang, Zhendong Sun, Ze Zhang, Qian S. Liu, Yuxin Zheng, Qunfang Zhou, Guibin Jiang   +8 more
doaj   +1 more source

Deregulated megakaryocytic maturation, mitochondrial function and inflammatory signalling in CYCS(c.292T>C)‐related thrombocytopenia [PDF]

Br J Haematol
British Journal of Haematology, Volume 208, Issue 3, Page 1153-1157, March 2026.
Giavi K, Fasouli E, Glentis S, Bouchla A, Apostolidou A, Marinakis N, Vatsellas G, Kontsioti F, Kattamis A, Pappa V, Katsantoni E.   +10 more
europepmc   +2 more sources

Highly efficient platelet generation in lung vasculature reproduced by microfluidics

Nature Communications, 2023
Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear.
Xiaojuan Zhao, Dominic Alibhai, Tony G. Walsh, Nathalie Tarassova, Maximilian Englert, Semra Z. Birol, Yong Li, Christopher M. Williams, Chris R. Neal, Philipp Burkard, Stephen J. Cross, Elizabeth W. Aitken, Amie K. Waller, José Ballester Beltrán, Peter W. Gunning, Edna C. Hardeman, Ejaife O. Agbani, Bernhard Nieswandt, Ingeborg Hers, Cedric Ghevaert, Alastair W. Poole   +20 more
doaj   +1 more source