Results 31 to 40 of about 7,460 (217)

A Loss of Function Screen of Identified Genome-Wide Association Study Loci Reveals New Genes Controlling Hematopoiesis [PDF]

, 2014
The formation of mature cells by blood stem cells is very well understood at the cellular level and we know many of the key transcription factors that control fate decisions.
A Brownlie, A Dey, AC Belkina, Ana Cvejic, C Garner, C Gieger, C Thisse, C-W Chung, CB Kimmel, CJ Ott, D Houzelstein, D Notani, Derek L. Stemple, DM Evans, DS Paul, DS Paul, E Shang, Ewa Bielczyk-Maczyńska, H Yao, HL Sheehan, HW Detrich, J Serbanovic-Canic, JM Lamonica, Jovana Serbanovic-Canic, JY Bertrand, L Zeng, Lauren Ferreira, Leonard I. Zon, Nicole Soranzo, P Filippakopoulos, P Filippakopoulos, P Jagadeeswaran, P van der Harst, S Kadauke, S Kadauke, S Saleque, ST Nurnberg, T Kanno, Willem H. Ouwehand   +38 more
core   +3 more sources

Haematopoietic thrombocyte precursors in rat femoral and sternal bone marrow

Bulgarian Journal of Veterinary Medicine, 2021
This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure ...
D. Suljević, A. Hamzić, E. Islamagić, E. Fejzić , A. Alijagić   +4 more
doaj   +1 more source

Targeting a thrombopoietin-independent strategy in the discovery of a novel inducer of megakaryocytopoiesis, DMAG, for the treatment of thrombocytopenia

Haematologica, 2022
Thrombocytopenia is a thrombopoietin (TPO)-related disorder with very limited treatment options, and can be lifethreatening. There are major problems with typical thrombopoietic agents targeting TPO signaling, so it is urgent to discover a novel TPO ...
Long Wang, Sha Liu, Jiesi Luo, Qi Mo, Mei Ran, Ting Zhang, Xiaoxuan Li, Wenjun Zou, Qibing Mei, Jianping Chen, Jing Yang, Jing Zeng, Feihong Huang, Anguo Wu, Chunxiang Zhang, Jianming Wu   +15 more
doaj   +1 more source

The ABC of Thrombopoiesis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Platelets play an important role in atherogenesis and atherothrombosis. At early stages of atherosclerosis, platelet-borne chemokines and platelet–leukocyte complexes contribute to the recruitment of neutrophils and monocytes to inflamed arteries.1,2 At late stages, platelets orchestrate additional processes such as thrombosis by direct mechanisms and ...
openaire   +2 more sources

Immature Platelet Counts and Thrombopoietin Plasma Concentrations in Thrombocytopenic and Non-thrombocytopenic Preterm Infants

Frontiers in Pediatrics, 2021
Objective: Immature platelet counts (IPC) may prove useful in guiding platelet transfusion management in preterm neonates. However, the relationship between IPCs and thrombopoietin (Tpo) concentrations has not been evaluated in preterm neonates.Methods ...
Hannes Sallmon, Hannes Sallmon, Hannes Sallmon, Andreas Weimann, Christoph Bührer, Boris Metze, Christof Dame, Malte Cremer   +7 more
doaj   +1 more source

Clinicopathological and targeted exome gene features of a patient with metastatic acinic cell carcinoma of the parotid gland harboring an ARID2 nonsense mutation and CDKN2A/B deletion [PDF]

, 2015
We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC). A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the ...
Momand, Jamil, Palma-Diaz, Fernando, Shibuya, Terry Y, Warner, Wayne A, Wong, Deborah J   +4 more
core   +4 more sources

Caulis Polygoni Multiflori Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways

Pharmaceuticals, 2022
Thrombocytopenia is one of the most common complications of cancer therapy. Until now, there are still no satisfactory medications to treat chemotherapy and radiation-induced thrombocytopenia (CIT and RIT, respectively). Caulis Polygoni Multiflori (CPM),
Xin Yang, Long Wang, Jing Zeng, Anguo Wu, Mi Qin, Min Wen, Ting Zhang, Wang Chen, Qibing Mei, Dalian Qin, Jing Yang, Yu Jiang, Jianming Wu   +12 more
doaj   +1 more source

Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation [PDF]

, 2014
The zinc finger transcriptional repressor Gfi-1b is essential for erythroid and megakaryocytic development in the embryo. Its roles in the maintenance of bone marrow erythropoiesis and thrombopoiesis have not been defined.
Amzallag, Arnaud, Behlich, Anna-Sophie, Foudi, Adlen, Hochedlinger, Konrad, Hock, Hanno, Kramer, Daniel J., Mordecai, Scott, Orkin, Stuart H., Preffer, Frederic I., Qin, Jinzhong, Ramaswamy, Sridhar, Ye, Denise   +11 more
core   +1 more source

Research progress of methodological techniques of generation of platelets from induced pluripotent stem cells in vitro

Zhongguo shuxue zazhi, 2023
Platelets play a role in hemostasis in vivo, and platelet transfusion is the main means to treat bleeding diseases caused by thrombocytopenia or platelet dysfunction.
Wei YUE, Haihui GU
doaj   +1 more source

The incredible journey: From megakaryocyte development to platelet formation [PDF]

, 2014
Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets.
Italiano, Joseph E., Machlus, Kellie R.
core   +1 more source