Results 1 to 10 of about 15,341 (157)

Identification of Plasma Thrombopoietin Level and Its Significance in Patients with Aplastic Anemia and Myelodysplastic Syndrome

Global Medical Genetics, 2023
Objective Our objective was to investigate the concentration of plasma thrombopoietin (TPO) in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS), as well as its relationship with patients' responses to recombined human TPO (
Mengying Zhang, Gaochao Zhang, Fangfang Xu, Mengyuan Liu, Xifeng Dong, Weiwei Qi, Huaquan Wang   +6 more
doaj   +1 more source

Safety, tolerance, pharmacokinetic and pharmacodynamic properties of thrombopoietin mimetic peptide for injection in Chinese healthy volunteers: a randomized, placebo-controlled, double-blind study

Platelets, 2022
The thrombopoietin mimetic peptide for injection is a second-generation thrombopoietin receptor agonist (TPO-RA) used in the treatment of patients with immune thrombocytopenia.
Xiao-Yan Sheng, Zhi-Yan Liu, Jing Zhao, Lei Song, Wen-Ming Zhao, Xia Zhao, Yi-Min Cui   +6 more
doaj   +1 more source

Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation. [PDF]

PLoS ONE, 2014
BACKGROUND: Newly formed platelets are associated with increased aggregation and adverse outcomes in patients with coronary artery disease (CAD). The mechanisms involved in the regulation of platelet turnover in patients with CAD are largely unknown. AIM:
Sanne Bøjet Larsen, Erik Lerkevang Grove, Anne-Mette Hvas, Steen Dalby Kristensen   +3 more
doaj   +1 more source

Post Dengue Reactive Thrombocytosis- A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2022
Dengue fever is common in tropical countries like India. Typically, dengue fever and dengue haemorrhagic fever is characterised by high grade fever with arthralgia, myalgia and headache.
Richa, Shikha Sadadiwala, Antan George, Pankaj Abrol, Shashi Sharma   +4 more
doaj   +1 more source

Comparison of Maternal Serum Levels of Thrombopoietin among Pregnant Women with and without Preeclampsia

Kufa Journal for Nursing Sciences, 2020
Background: Preeclampsia is a syndrome and considered one of the most significant causes that can lead to maternal and fetal morbidity and mortality.
Rusul Jabbar Tauma, Zainab H. Al-Kakajy
doaj   +1 more source

Romiplostim for chemotherapy‐induced thrombocytopenia: Efficacy and safety of extended use

Research and Practice in Thrombosis and Haemostasis, 2022
Background Chemotherapy‐induced thrombocytopenia (CIT) is common during treatment with antineoplastic therapies and may adversely impact chemotherapy dose intensity. There is no approved therapy for CIT.
Cy R. Wilkins, Jocelyn Ortiz, Leah J. Gilbert, Shen Yin, Jodi V. Mones, Rekha Parameswaran, Simon Mantha, Gerald A. Soff   +7 more
doaj   +1 more source

Bone marrow fibrosis in 66 patients with immune thrombocytopenia treated with thrombopoietin-receptor agonists: a single-center, long-term follow-up

Haematologica, 2014
Thrombopoietin-receptor agonists increase platelet counts by stimulating the thrombopoietin receptor. Bone marrow fibrosis has been reported in patients receiving thrombopoietin-receptor agonists.
Waleed Ghanima, Julia Turbiner Geyer, Christina S. Lee, Leonardo Boiocchi, Allison A. Imahiyerobo, Attilio Orazi, James B. Bussel   +6 more
doaj   +1 more source

The thrombopoietin receptor: revisiting the master regulator of platelet production

Platelets, 2021
Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet production and critical for hematopoietic stem cell (HSC) maintenance.
Ian S. Hitchcock, Maximillian Hafer, Veena Sangkhae, Julie A. Tucker   +3 more
doaj   +1 more source

Trombinol, a bioactive fraction of Psidium guajava, stimulates thrombopoietin expression in HepG2 cells

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To study the regulation of trombinol on thrombopoietin, an essential regulator of thrombocyte production. Methods: Effect of trombinol on thrombopoietin regulation was evaluated at the mRNA and protein levels in human hepatoma HepG2 cells. The
Guntur Berlian, Olivia Mayasari Tandrasasmita, Raymond Rubianto Tjandrawinata   +2 more
doaj   +1 more source

Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation

eLife, 2021
The bone marrow niche plays critical roles in hematopoietic recovery and hematopoietic stem cell (HSC) regeneration after myeloablative stress. However, it is not clear whether systemic factors beyond the local niche are required for these essential ...
Longfei Gao, Matthew Decker, Haidee Chen, Lei Ding   +3 more
doaj   +1 more source