Results 51 to 60 of about 3,493 (184)

Increased cardiovascular mortality in females with the a/a genotype of the SNPs rs1478604 and rs2228262 of thrombospondin-1

BMC Medical Genetics, 2020
Background Cardiovascular diseases are still the major cause of death in the Western world, with different outcomes between the two genders.
Urban Alehagen, Levar Shamoun, Dick Wågsäter   +2 more
doaj   +1 more source

Negative regulators of angiogenesis, ocular vascular homeostasis, and pathogenesis and treatment of exudative AMD

Journal of Ophthalmic & Vision Research, 2018
Angiogenesis, the formation of new blood vessels from pre-existing capillaries, is very tightly regulated and normally does not occur except during developmental and reparative processes.
Mitra Farnoodian, Christine M Sorenson, Nader Sheibani   +2 more
doaj   +1 more source

Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts

Journal of Neuroinflammation, 2020
Background Current methods to repair ablation-type peripheral nerve injuries (PNIs) using peripheral nerve allografts (PNAs) often result in poor functional recovery due to immunological rejection as well as to slow and inaccurate outgrowth of ...
Tyler A. Smith, Cameron L. Ghergherehchi, Haley O. Tucker, George D. Bittner   +3 more
doaj   +1 more source

Thrombospondin-1 [PDF]

Circulation Research, 2013
The incidence of diabetes mellitus has increased exponentially over the past 2 decades, and individuals with diabetes mellitus are at increased risk for and have poor prognosis with cardiovascular disease.1 In the myocardium, diabetes mellitus enhances fatty acid metabolism, inhibits glucose oxidation, and modifies intracellular signaling, eventually ...
Yonggang, Ma, Andriy, Yabluchanskiy, Merry L, Lindsey   +2 more
openaire   +2 more sources

Thrombospondins in human aortic aneurysms

Thrombospondins are a family of matricellular proteins with a multimeric structure that is known to be involved in several biological and pathological processes. Their relationship with vascular disorders has raised special interest recently.
Miralles Hernández, Manuel, Requejo, Lucía, Medina Badenes, Pilar, Fernández-Pardo, Álvaro, Herranz, Raquel, Oto, Julia, Plana-Andani, Emma   +6 more
core   +1 more source

Uncovering the Role of Astrocyte-Secreted Thrombospondins and Their Neuronal Receptor α2δ-1 in Goal-Directed Actions

, 2023
Goal-directed actions (GDAs), the optimal set of actions to achieve an outcome, are voluntary behaviors requiring complex cognitive processes. Cortico-striatal circuits, particularly neuronal projections from the prefrontal cortex to the dorsomedial ...
Lawal, Oluwadamilola
core  

Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells

Adipocyte
Adipogenesis from mouse embryonic stem cells (mESCs) offers a tractable model for dissecting early adipocyte commitment, yet the mechanisms coordinating this transition across multiple biological layers remain incompletely understood. Here we present the
M. Al-Sayegh, M. Khalili, M. Alzaabi, M. Sultana, L. Ali, M. Ali, M. El-Hadidi   +6 more
doaj   +1 more source

Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes

Disease Models & Mechanisms, 2015
Impaired angiogenesis and endothelial dysfunction in type 2 diabetes constitute dominant risk factors for non-healing wounds and most forms of cardiovascular disease.
Milad S. Bitar, Fahd Al-Mulla
doaj   +1 more source

Structures of thrombospondins [Review]

, 2008
Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs ...
Mosher, Deane F., M.D., Lawler, Jack, Carlson, C. Britt   +2 more
core  

Diabetes increases SCO-spondin secretion but reduces Wnt5a interaction with ependymal cells, inducing ciliary stiffness and Frizzled-2 downregulation

Neurobiology of Disease
Diabetes is a chronic metabolic disorder with systemic complications. Hyperglycemia damages multiple organs, including the brain, increasing the risks of stroke, dementia, and oxidative stress.
Manuel Cifuentes, Eder Ramírez, María José Barahona, Fernando Martínez, Isabelle de Lima, Luciano Ferrada, Romina Bertinat, Felipe Ávila, Natalia Saldivia, Margarita Pérez-Martín, Begoña Oliver-Martin, Nicolás Ciano-Petersen, María del Mar Fernández-Arjona, Katterine Salazar, Francisco Nualart   +14 more
doaj   +1 more source