Results 31 to 40 of about 3,493 (184)
F1000Research, 2018 Voltage-gated calcium (CaV) channels are associated with β and α2δ auxiliary subunits. This review will concentrate on the function of the α2δ protein family, which has four members.
Annette C. Dolphin
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Thrombospondin production and thrombospondin-mediated adhesion in U937 cells [PDF]
Experimental Cell Research, 1991 U937 cells have low levels of surface thrombospondin (TSP) under control conditions but express higher levels after treatment for 1 day with 100 nM phorbol myristate acetate (PMA). Increased surface expression is due, in part, to increased biosynthesis.
Varani, James +9 more
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, 2021 Thrombospondins (TSPs) are multi-domain, secreted proteins that associate with cell-surfaces and extracellular matrix. In mammals, there is a large body of data on functional roles of various TSP family members in cardiovascular disease (CVD), including ...
Pauza, Audrys G +2 more
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ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia
Hypertension in Pregnancy, 2018 The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies.
Müberra Namlı Kalem +3 more
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Neurobiology of Disease, 2017 The alpha2delta-1 subunit (α2δ-1) of voltage-gated calcium channels is a receptor for astrocyte-secreted thrombospondins that promote developmental synaptogenesis.
Leonardo C. Faria +5 more
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Thrombospondin in essential thrombocythemia [PDF]
Blood, 1986 Abstract Essential thrombocythemia is a myeloproliferative disorder characterized by frequent bleeding and thrombotic complications. On a molecular level, two abnormalities of platelet thrombospondin have been identified: abnormal glycosylation of the intact 185,000-dalton chain has been detected and a shortened form of the ...
J, Lawler +3 more
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Imbalance of angiogenesis in diabetic complications: The mechanisms
International Journal of Preventive Medicine, 2012 Type 2 diabetes mellitus is a complex disease and a chronic health-care problem. Nowadays, because of alteration of lifestyle such as lack of exercise, intake of high fat diet subsequently obesity and aging population, the prevalence of diabetes mellitus
Zoya Tahergorabi, Majid Khazaei
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Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth [PDF]
, 1995 Extracellular matrix (ECM) molecules are involved in multiple aspects of cell-to-cell signaling during development and in the adult. In nervous system development, specific recognition processes, e.g., during axonal pathfinding and synaptogenesis involve
Arber, S., P Caroni, S Arber, Caroni, P.
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Thrombospondins and synaptogenesis.
Neural regeneration research, 2012 Here, we review research on the mechanisms underlying the ability of thrombospondin to promote synaptogenesis and examine its role in central nervous system diseases and drug actions. Thrombospondin secreted by glial cells plays a critical role in synaptogenesis and maintains synapse stability.
Wang, Bin, Guo, Weitao, Huang, Yun
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Thrombospondin in Renal Disease [PDF]
Nephron Experimental Nephrology, 2009 Thrombospondins (TSPs) are multifunctional matricellular glycoproteins which are involved in the regulation of angiogenesis, proliferation, apoptosis, the NO-cGMP-dependent protein kinase pathway and transforming growth factor (TGF) β activation. The TSP family consists of 5 members, but currently only data on effects of TSP-1 and TSP-2 in renal ...
Hugo, Christian, Daniel, Christoph
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